Ultra-Miniature Dosimeter with Magnetic Localization

具有磁定位功能的超小型剂量计

• 批准号: 7998689
• 负责人: Timothy H. Riehle
• 金额: $ 12.9万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7998689
• 关键词: Accounting; Atlases; Autacoids; Biomedical Technology; Brain; Cancer Center; Complex; Computers; Consult; Coupled; Detection; Devices; Dose; Dose Fractionation; Electronics; Environment; External Beam Radiation Therapy; Film; Freedom; Goals; Head; Image; Implant; Intensity-Modulated Radiotherapy; Ionizing radiation; Laboratories; Lead; Lesion; Location; Magnetism; Measurement; Medical; Medical Oncologist; Motion; Movement; Nanotechnology; Normal tissue morphology; Organ; Patients; Phase; Positioning Attribute; Procedures; Property; Radiation; Radiation Oncologist; Radiation Oncology; Radiation therapy; Radio; Radiobiology; Radiosurgery; Research Personnel; Resolution; Respiration; Rotation; Safety; Shapes; Signal Transduction; Simulate; Site; Specificity; System; Techniques; Technology; Three-Dimensional Imaging; Time; Tissues; Toxic effect; Update; Visit; Wireless Technology; Work; X-Ray Computed Tomography; base; cancer cell; cancer therapy; cost; design; dosimetry; experience; improved; in vivo; magnetic field; millimeter; new technology; next generation; programs; public health relevance; response; sensor; simulation; solid state; success; targeted delivery; transmission process; treatment planning; tumor

DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a wireless implantable dosimeter with the ability to track both location and orientation in real-time by combining radiation sensitive field- effect-device (RADFET) technology together with ultra-miniature magnetic field sensors based on giant magnetoresistance (GMR) technology. These devices will be combined into an implantable package together with power and wireless radio circuitry and antenna. The combination of real-time tumor tracking coupled with accurate dosimetry at the tumor site will enable radiation oncology teams to increase targeting accuracy and enhance dose delivery precision. Fast real-time targeting can offer reduced procedure setup time, increased work flow and provide real-time tumor location and orientation thereby reducing targeting inaccuracy due to inter- and intrafractional motion. The proposed program uses solid-state thin-film GMR sensors to reduce the size, increase the sensitivity and decrease the cost of the magnetic targeting system. Solid-state FET dosimeter technology provides similar benefits: excellent sensitivity, small size and inexpensive manufacturing costs. PUBLIC HEALTH RELEVANCE: Koronis Biomedical Technologies proposes an implantable dosimeter system with location sensing capability using a solid-state field-effect-device (FET) dosimeter together with thin-film giant magnetoresistive (GMR) sensors. These technologies will enable the real-time tracking of both position and orientation enabling of tumors via non-ionizing magnetic fields.

描述（由申请人提供）：Koronis Biomedical Technologies（KBT）拟开发一种无线植入式剂量计，通过将辐射敏感场效应器件（RADFET）技术与基于巨磁阻（GMR）技术的超小型磁场传感器相结合，能够实时跟踪位置和方向。这些器械将与电源和无线电电路和天线一起组合到植入式包装中。实时肿瘤跟踪与肿瘤部位的精确剂量测定相结合，将使放射肿瘤学团队能够提高靶向准确性并提高剂量输送精度。快速实时靶向可以缩短手术设置时间，增加工作流程，并提供实时肿瘤位置和方向，从而减少由于分次间和分次内运动导致的靶向不准确性。该方案使用固态薄膜GMR传感器，以减小尺寸，提高灵敏度和降低磁靶向系统的成本。固态FET剂量计技术提供了类似的好处：出色的灵敏度，小尺寸和低廉的制造成本。 公共卫生相关性：Koronis Biomedical Technologies提出了一种具有位置感测能力的植入式剂量计系统，该系统使用固态场效应器件（FET）剂量计以及薄膜巨磁阻（GMR）传感器。这些技术将能够通过非电离磁场实时跟踪肿瘤的位置和方向。