MULTILEVEL INTERPLAYS IN THE DEVELOPMENT OF TOBACCO DEPENDENCE

烟草依赖发展中的多层次相互作用

• 批准号: 9367143
• 负责人: Min Lian
• 金额: $ 34.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9367143
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Area; Behavioral Genetics; Censuses; Characteristics; Chronic; Cigarette; Cohort Studies; Complex; DSM-V; Data; Data Sources; Development; Diagnostic and Statistical Manual of Mental Disorders; Disease; Education; Employment Status; Environment; Etiology; Event; Exposure to; Family; Family Characteristics; Female; Female Adolescents; Follow-Up Studies; Genes; Genetic; Genetic Markers; Genetic Models; Genetic Predisposition to Disease; Genetic Risk; Geographic Information Systems; Geography; Health; Individual; Intervention; Knowledge; Lead; Link; Location; Longitudinal Studies; Marital Status; Measures; Missouri; Neighborhoods; Nicotine Dependence; Nicotinic Receptors; Pattern; Play; Prevalence; Preventive Intervention; Prospective Studies; Prospective cohort study; Public Health; Recording of previous events; Research; Risk; Risk Factors; Role; Sales; Smoke; Smoker; Smoking; Smoking Behavior; Socioeconomic Status; Statistical Models; Structural Models; Structure; Subgroup; Symptoms; Taxes; Time; Tobacco; Tobacco Dependence; Tobacco use; Twin Multiple Birth; Twin Studies; Uncertainty; United States; Update; Youth; adolescent smoking; base; deprivation; follow-up; geographic difference; high risk; neighborhood disadvantage; neighborhood safety; non-genetic; novel; prospective; public policy on tobacco; socioeconomics; tobacco control; tool; vigilance; young adult

PROJECT SUMMARY Tobacco use in adolescents and young adults remains one of the most challenging public health issues in the United States. Adolescence and young adulthood represent a window of heightened vulnerability to tobacco use. A high proportion of adolescent tobacco users develop tobacco dependence during the adolescence and young adulthood. Thus, full understanding of the risk mechanisms of tobacco dependence is critical for multilevel interventions to reduce the risk of developing tobacco dependence. Although individual-level genetic and nongenetic risk factors for tobacco dependence have been established, only few prospective studies have assessed neighborhood effects on smoking behaviors. The role of neighborhood conditions and gene- neighborhood interplays in the development of tobacco dependence, particularly among adolescents and young adults, remain unclear. In addition, as a common event in longitudinal studies, mobility-induced change of neighborhood exposures may have an impact on smoking behaviors, which were ignored in the previous research and might lead to inaccurate estimations of neighborhood effects. The Missouri Adolescent Female Twin Study (MOAFTS) is a well-characterized prospective cohort study in which individual- and family-level information and residential histories were collected at baseline and updated periodically during the 20-year followup. This provides us a unique opportunity to examine the main and interactive effects of neighborhood exposures on tobacco dependence. Specifically, we will longitudinally assess the impacts of neighborhood conditions on the development of tobacco dependence (Aim 1) and characterize the geographic pattern of within-subject changes in neighborhood exposures and its effect on the development of tobacco dependence (Aim 2). Furthermore, we will prospectively examine the interactive effects of neighborhood exposures and genetic predisposition on the risk for tobacco dependence among adolescents and young adults (Aim 3). National and statewide data sources will be used to develop various small-area neighborhood measures that will be linked to the MOAFTS cohort. By integrating marginal structural modeling to multilevel behavioral genetic modeling, we will accurately assess the role of neighborhoods and gene-neighborhood interactions in tobacco dependence by controlling for mobility-induced spatial uncertainty. To our knowledge, this will be the first prospective study to comprehensively assess the role of neighborhood conditions and gene-neighborhood interplays in the development of tobacco dependence among adolescents and young adults. The results will refine our understanding of the risk mechanisms of tobacco dependence and inform multi-level strategies for reducing tobacco dependence among adolescents and young adults, ultimately reducing the burden of tobacco-related diseases.

项目摘要 在青少年和年轻人中使用烟草仍然是最具挑战性的公共卫生问题之一 美国。青春期和年轻成年代表着烟草脆弱性的窗口 使用。在青春期期间，很大一部分的青少年烟草用户会发展出烟草依赖性 年轻成年。因此，完全了解烟草依赖的风险机制对于 多层干预措施，以减少发展烟草依赖的风险。虽然是个体水平的遗传 以及已经建立了烟草依赖性的非肾上腺素危险因素，只有前瞻性研究才有 评估邻里对吸烟行为的影响。邻里条件和基因的作用 烟草依赖发展中的邻里相互作用，尤其是在青少年和 年轻人，尚不清楚。另外，作为纵向研究的常见事件，流动性诱导的变化 邻里暴露可能会对吸烟行为产生影响，这在以前被忽略了 研究并可能导致对邻里影响的估计不准确。密苏里青少年女性 双胞胎研究（MOAFTS）是一项良好的前瞻性队列研究，其中个人和家庭级别 在基线时收集信息和住宅历史，并在20年期间定期更新 后续。这为我们提供了一个独特的机会来检查邻里的主要和互动效果 暴露于烟草依赖性。具体而言，我们将纵向评估邻里的影响 关于烟草依赖性发展的条件（AIM 1），并表征 受试者内邻里暴露及其对烟草依赖性发展的影响 （目标2）。此外，我们将前瞻性地研究邻里暴露和 青少年和年轻人在烟草依赖风险上的遗传倾向（AIM 3）。 国家和全州数据来源将用于制定各种小区域邻里措施 将链接到Moafts队列。通过将边际结构建模与多级行为相结合 遗传建模，我们将准确评估邻里和基因 - 纽约期相互作用的作用 通过控制迁移率引起的空间不确定性来依赖烟草。据我们所知，这将是 首次前瞻性研究，以全面评估邻里状况和基因邻居的作用 青少年和年轻人之间烟草依赖性发展的相互作用。结果将 完善我们对烟草依赖的风险机制的理解，并为多层次的策略提供信息 减少青少年和年轻人之间的烟草依赖性，最终减轻 与烟草有关的疾病。