Neuroinflammation and Aggression

 描述(由申请人提供)：在这份申请中，我们建议在先前关于神经炎症在攻击和社会情绪信息处理中的作用的工作的基础上再接再厉。来自我们实验室和其他实验室的临床前动物研究和最近的人类研究都支持这样的假设，即炎症过程是促进攻击行为的重要调节器。人类受试者的研究都来自于对外周的研究，而不是对中枢炎症标志物/介质的研究，并且仅限于一到两个标志物(例如，C反应蛋白和IL-6)。在这项研究中，我们建议检验这样一种假设：(A)中枢神经系统中的各种炎症标志物/介质(即，在脑脊液中测量的)在维度上与攻击行为有关(即，如果它们反映和/或与攻击行为的关系比外围炎症措施更好)，以及(B)这些炎症标志物/介质在社会情绪信息处理中发挥作用，社会情绪信息处理是人类攻击行为的重要组成部分，正如基于人体实验工作和我们自己的试点数据所预期的那样。

 DESCRIPTION (provided by applicant): In this application, we propose to build on previous work regarding the role of neuroinflammation in aggression and in social-emotional information processing. Both preclinical animal studies and recent human studies from our lab, and other labs, support the hypothesis that inflammatory processes are an important modulator that facilitates aggressive behavior. Work in human subjects have all been from the study of peripheral, as opposed to central, inflammatory marker/mediators and have been limited to only one or two markers (e.g., C-Reactive Protein and IL-6). In this study, we propose to test the hypothesis that: (a) various inflammatory marker/mediators in the central nervous system (i.e., measured in cerebrospinal fluid) are dimensionally related to aggressive behavior (i.e., if they mirror, and/or better relate to aggression than, peripheral inflammatory measures) and, (b) that these inflammatory marker/mediators play a role in social-emotional information processing, an important component of human aggressive behavior, as expected based on experimental work in human subjects and from our own pilot data.