Development of fMRI Studies of Social-Emotional Information Processing

描述（由申请人提供）：在此R21应用程序中，我们建议建立在最近开发的社会情感信息处理（SEIP）视觉刺激的基础上。这些刺激是由短视频剪辑的基础上写的SEIP小插曲，已经被证明具有良好的心理测量特性。我们建议开发和完善功能磁共振成像协议，以检查神经网络相关的各个方面的SEIP。这些与观看（编码），敌意归因和负面情绪反应有关。第一组受试者将包括健康志愿者受试者。第二组受试者将包括具有复发性、问题性、冲动性攻击（间歇性爆炸性障碍：IED）突出历史的个体。fMRI-SEIP协议将定义健康志愿者中参与SEIP不同方面的神经网络。然后，将在有复发性、问题性、冲动性攻击（IED）病史的受试者中研究fMRI方案。我们假设：a）在“观看阶段”，在与认知评价相关的脑区域中将观察到增加的fMRI BOLD信号响应（DLPFC，OFC，PHG）和情感反应（AMYG，ACC，INS），B）在“归因阶段”，在与认知评价相关的脑区域中将观察到增加的fMRI BOLD信号响应（DLPFC，OFC，PHG，PCN），c）在“负性情绪反应阶段”期间，在与情感反应相关的脑区域中将观察到增加的fMRI BOLD信号反应（AMYG，ACC，INS）和，d）“敌对归因”和“消极情绪反应”的得分（这两者都意味着被激起的愤怒/敌意/负面情绪的程度）分数将与AMYG、ACC、OFC和INS的激活相关。最后，我们假设，与健康对照受试者相比，冲动性攻击受试者（IED）在DLPFC、OFC、PHG和PCN的归因（认知评价）过程中表现出减少的大脑激活，而在AMYG、ACC、INS的“消极情绪反应”（情感反应）过程中表现出增加的大脑激活。

DESCRIPTION (provided by applicant): In this R21 application, we propose to build on work with recently developed Social-Emotional Information processing (SEIP) visual stimuli. These stimuli are composed of short video clips based on written SEIP vignettes that have already been shown to have excellent psychometric properties. We propose to develop and refine an fMRI protocol to examine neural networks related to the various aspects of SEIP. These relate to viewing (encoding), hostile attribution, and negative emotional response. The first group of subjects will include healthy volunteer subjects. The second group of subjects will include individuals with prominent histories of recurrent, problematic, impulsive aggression (Intermittent Explosive Disorder: IED). The fMRI-SEIP protocol will define the neural networks involved in the different aspects of SEIP in healthy volunteers. Then the fMRI protocol will be studied in subjects with histories of recurrent, problematic, impulsive aggression (IED). We hypothesize that: a) during the "Viewing Phase", increased fMRI BOLD signal response will be observed in brain regions associated with cognitive appraisal (DLPFC, OFC, PHG) and affective reaction (AMYG, ACC, INS), b) during the "Attribution Phase", increased fMRI BOLD signal response will be observed in brain regions associated with cognitive appraisal (DLPFC, OFC, PHG, PCN), c) during the "Negative Emotional Response Phase", increased fMRI BOLD signal response will be observed in brain regions associated with affective reaction (AMYG, ACC, INS) and that, d) scores of "Hostile Attribution" and of "Negative Emotional Response" (which both connote the extent of provoked anger/hostility/negative affect) scores will correlate with activation of AMYG, ACC, OFC, and INS. Finally, we hypothesize that, compared with Healthy Control subjects, impulsive aggressive subjects (IED) will demonstrate reduced brain activation during the Attribution (cognitive appraisal) in DLPFC, OFC, PHG, and PCN and heightened brain activation during the "Negative Emotional Response" (affective reaction) in AMYG, ACC, INS.