Development of fMRI Studies of Social-Emotional Information Processing

描述（由申请人提供）：在这个R21申请中，我们建议建立在最近开发的社会情绪信息处理（SEIP）视觉刺激的基础上。这些刺激是由基于书面SEIP小插曲的短视频剪辑组成的，这些小插曲已经被证明具有出色的心理测量特性。我们建议发展和完善一个功能磁共振成像协议来检查与SEIP的各个方面相关的神经网络。这些与观看（编码）、敌意归因和负面情绪反应有关。第一组受试者包括健康志愿者。第二组受试者将包括有反复发作、有问题、冲动攻击（间歇性爆发障碍：IED）的突出病史的个体。fMRI-SEIP协议将定义参与健康志愿者SEIP不同方面的神经网络。然后，fMRI方案将在有复发性、问题性、冲动攻击（IED）病史的受试者中进行研究。我们假设：a)在“观看阶段”，与认知评价（DLPFC、OFC、PHG）和情感反应（AMYG、ACC、INS）相关的脑区会观察到fMRI BOLD信号反应增加；b)在“归因阶段”，与认知评价（DLPFC、OFC、PHG、PCN）相关的脑区会观察到fMRI BOLD信号反应增加；c)在“消极情绪反应阶段”。在与情感反应（AMYG、ACC、INS）相关的大脑区域，fMRI BOLD信号反应增加，并且，d)“敌意归因”和“负面情绪反应”（两者都包含被激怒的愤怒/敌意/负面影响的程度）得分与AMYG、ACC、OFC和INS的激活相关。最后，我们假设，与健康对照组相比，冲动攻击被试在DLPFC、OFC、PHG和PCN的归因（认知评价）过程中表现出较低的脑激活，而在AMYG、ACC、INS的“负性情绪反应”（情感反应）过程中表现出较高的脑激活。

DESCRIPTION (provided by applicant): In this R21 application, we propose to build on work with recently developed Social-Emotional Information processing (SEIP) visual stimuli. These stimuli are composed of short video clips based on written SEIP vignettes that have already been shown to have excellent psychometric properties. We propose to develop and refine an fMRI protocol to examine neural networks related to the various aspects of SEIP. These relate to viewing (encoding), hostile attribution, and negative emotional response. The first group of subjects will include healthy volunteer subjects. The second group of subjects will include individuals with prominent histories of recurrent, problematic, impulsive aggression (Intermittent Explosive Disorder: IED). The fMRI-SEIP protocol will define the neural networks involved in the different aspects of SEIP in healthy volunteers. Then the fMRI protocol will be studied in subjects with histories of recurrent, problematic, impulsive aggression (IED). We hypothesize that: a) during the "Viewing Phase", increased fMRI BOLD signal response will be observed in brain regions associated with cognitive appraisal (DLPFC, OFC, PHG) and affective reaction (AMYG, ACC, INS), b) during the "Attribution Phase", increased fMRI BOLD signal response will be observed in brain regions associated with cognitive appraisal (DLPFC, OFC, PHG, PCN), c) during the "Negative Emotional Response Phase", increased fMRI BOLD signal response will be observed in brain regions associated with affective reaction (AMYG, ACC, INS) and that, d) scores of "Hostile Attribution" and of "Negative Emotional Response" (which both connote the extent of provoked anger/hostility/negative affect) scores will correlate with activation of AMYG, ACC, OFC, and INS. Finally, we hypothesize that, compared with Healthy Control subjects, impulsive aggressive subjects (IED) will demonstrate reduced brain activation during the Attribution (cognitive appraisal) in DLPFC, OFC, PHG, and PCN and heightened brain activation during the "Negative Emotional Response" (affective reaction) in AMYG, ACC, INS.