权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Aggression and SEIP: Neural Correlates During Alcohol Intoxication

攻击性和 SEIP：酒精中毒期间的神经相关性

基本信息

批准号：
10266858
负责人：
EMIL Frank COCCARO
金额：
$ 63.9万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-05 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10266858
关键词：
Acute Address Affect Aggressive behavior Alcohol consumption Alcoholic Intoxication Alcohols Amygdaloid structure Behavioral Brain Closure by clamp Cognitive Complex Control Groups Corpus striatum structure Cues DSM-V Data Dose Emotional Equilibrium Executive Dysfunction Exercise Fostering Functional Magnetic Resonance Imaging Human Impairment Impulsivity Individual Infusion procedures Injury Intermittent Explosive Disorders Intervention Intravenous Laboratories Lead Link Measures Methodology Nature Neuronal Plasticity Neurons Neurosciences Participant Pharmacology Process Randomized Recording of previous events Recurrence Rehabilitation therapy Reporting Risk Saline Signal Transduction Social Environment Societies Structure System Testing Ventral Striatum alcohol abuse therapy alcohol effect alcohol free alcohol misuse alcohol use disorder assault base blood oxygenation level dependent response cognitive function comorbidity cortico-limbic circuits functional MRI scan improved information processing insight life history neural circuit neural correlate neural information processing neuronal circuitry non-alcoholic novel relating to nervous system remediation response social social neuroscience trait violent crime

项目摘要

Project Summary: The specific aim of this project is to experimentally examine the effect of alcohol on aggressive and impulsive responding, and on social-emotional information processing (SEIP) responses to threat, in individuals as a function of Alcohol Use Disorder (AUD) and prominent history of recurrent, problematic, impulsive aggressive behavior (AGG). While alcohol use is associated with impulsive aggression, little is known about the system neuroscience nature of this association except that the link between alcohol and aggression is most clear, and strongest, in individuals who are already high in trait aggression. Recent reports suggest that history of high lifetime alcohol use, in addition to acute alcohol dosing, dampens both cortical and subcortical responses to threat. In addition, acute alcohol administration appears to reduce cortical-subcortical connectivity, which some suggest is the primary correlate of alcohol-related aggressive behavior. However, this cannot explain all cases of alcohol-related aggression because neuronal correlates of aggression in non-alcoholics include an over, rather than under-activation of subcortical structures (i.e., amygdala) in the alcohol-free state. To advance our understanding of these complex relationships, we propose to study neuronal responses to socio-emotional threat in four groups of subjects: a) AUD and AGG (AUD+AGG); b) AUD without AGG (AUD); c) IED without AUD (AGG); and d) Healthy Controls (AUD-/AGG-), to uncover behavioral and neuro-circuitry differences in impulsive aggression and in the neuronal response to threat as a function of a history of AUD. Specifically, this study proposes to test the hypothesis that alcohol intoxication (0.08 mg%) is associated with increases in aggressive responding, and impairment in measures of SEIP, and to test the hypothesis that alcohol intoxication further affects cortico-limbic function in ways to increase the risk of impulsive aggression, though, perhaps, by different neuronal mechanisms as a function of AUD. Subjects will complete two (2) study sessions, in randomized order, in which each will receive intravenous alcohol (using alcohol clamp methodology), with alcohol doses clamped to achieve steady state alcohol breath levels of 0.08 mg%. Subjects will then complete a human laboratory aggression task and then an fMRI scanning session including two social-emotional information processing tasks: a) one that taps into the processing of explicit emotional cues of threat and, b) one that taps into the processing of ambiguous social cues of threat.

项目概述：本项目的具体目的是通过实验研究酒精对