Nitrous Oxide and Cortico-Limbic Function in Aggression

攻击行为中的一氧化二氮和皮质边缘功能

基本信息

批准号：
9896211
负责人：
EMIL Frank COCCARO
金额：
$ 19.5万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9896211
关键词：
Acute Aggressive behavior Amygdaloid structure Anesthetics Anger Animal Model Animals Antidepressive Agents Behavior Behavioral Brain-Derived Neurotrophic Factor Cell physiology Cerebrospinal Fluid Chronic Clinical Complex Coupled Craniocerebral Trauma DSM-V Dendritic Spines Depressed mood Disease Emotional Emotions Event FDA approved Face Functional Magnetic Resonance Imaging Glutamates Hour Human Impulsivity Individual Inflammatory Infusion procedures Inhalation Intermittent Explosive Disorders Intoxication Ketamine Lead Measures Mental Depression N-Methyl-D-Aspartate Receptors N-Methylaspartate Natural regeneration Neuroglia Neurotransmitters Nitrous Oxide Participant Pharmaceutical Preparations Phase Play Population Protocols documentation Psychotic Disorders Recording of previous events Recurrence Rest Role Series Serotonin Signal Transduction System Testing Thinking Time Treatment Efficacy Withdrawal Work antidepressant effect cortico-limbic circuits cytokine functional MRI scan human subject improved improved functioning infancy information processing interest neurochemistry neuroimaging pre-clinical response social stem treatment-resistant depression

项目摘要

Project Summary In this application, we propose to build on previous work regarding the role of glutamate in impulsive aggression. Both preclinical animal studies and recent human studies from our labs and other labs support the hypothesis that glutamate is an important modulator that facilitates aggressive behavior. In this study, we propose to use an FDA approved glutamatergic modulator, Nitrous Oxide (N2O), to determine if N2O has the ability to normalize cortico-limbic circuits previously associated with impulsive aggressive behavior in humans. Impulsive aggressive, and healthy non-aggressive control, study participants will undergo two inhalation protocols (50% N2O / 50% O2 as active and 50% N2 / 50% O2 as control) separated by at least one week and undergo an fMRI Scan 24 hours after each inhalation study session. If this mechanistic study demonstrates that N2O inhalation can normalize the functioning of these circuits, N2O may represent a candidate as an anti-aggressive agent.

项目摘要在此应用程序中，我们建议以谷氨酸在脉冲中的作用为基础侵略。临床前动物研究和我们实验室和其他实验室的最新人类研究都支持假设谷氨酸是促进侵略行为的重要调节剂。在这项研究中，我们建议使用FDA批准的谷氨酸能调节剂一氧化二氮（N2O）来确定N2O是否具有能够使先前与冲动性攻击行为相关的皮质膜电路标准化人类。脉冲侵略性和健康的非攻击性控制，研究参与者将接受两个吸入方案（50％N2O / 50％O2作为活性和50％N2 / 50％O2作为对照）至少分开每次吸入研究后24小时，一周进行fMRI扫描。如果这项机械研究证明N2O吸入可以使这些电路的功能正常化，N2O可能代表A 候选人作为反攻击剂。