Psychometric Integrative Technology for Cognitive Health Research

 描述（由申请人提供）：在美国境外进行的许多老年人健康和认知调查均以美国健康与退休研究 (HRS) 为蓝本。这些国际姐妹研究 (ISS) 均使用不同的方法来评估认知功能。这些差异，加上参与者的环境、语言、人口和健康特征的差异，使得很难就跨国认知障碍水平的相似性和差异得出明确的结论。决策者和公共卫生领导人对在国际范围内比较痴呆症和更广泛的认知障碍发生率的能力感兴趣。卫生部需要有关老年公民认知障碍的相对负担和潜在影响的可靠信息，以评估以前的公众反应和未来应对人口变化的计划。我们的团队是一个富有成效的多学科团队，代表认知衰老、心理测量学、神经心理学、医学、老年学和流行病学方面的专业知识。我们在这些领域有着长期的合作记录，并在 HRS 国际姐妹研究中拥有丰富的应用经验，包括与当前应用直接相关的心理测量关联研究。我们团队的成员还包括使用最先进的心理测量和计算方法来标准化和现代化健康和认知评估的前沿专家。我们的应用程序将：1）协调和共同校准 HRS 系列研究中的认知评估，2）确定测量有效性的限制，3）并为未来的工作和仪器开发提出具体建议。我们将利用 HRS 和 ISS 以及其他现有研究来实现这些目标，包括简短的精神状态评估、神经心理学测试以及认知衰老和痴呆的相关临床结果（神经影像学、神经病理学和纵向病程）。

 DESCRIPTION (provided by applicant): A number of surveys of health and cognition in older adults conducted outside of the US are modeled after the US Health and Retirement Study (HRS). Each of these international sister studies (ISS) uses different methods to assess cognitive functioning. These differences, combined with differences in the environment, languages, demographic and health characteristics of the participants make it difficult to draw clear conclusions regarding similarities and differences in the level of cognitive impairment cross-nationally. The ability to compare rates of dementia and more broadly cognitive impairment internationally is of interest to policy makers and public health leaders. Health ministries require reliable information regarding the comparative burden and potential impact of cognitive impairment among their older citizens to evaluate previous public responses and plans for future responses to demographic shifts. Our team is a productive and multidisciplinary group representing expertise in cognitive aging, psychometrics, neuropsychology, medicine, gerontology, and epidemiology. We have a long track record of collaboration in these areas, and extensive applied experience with the HRS international sister studies, including psychometric linking studies with direct relevance to the current application. Members of our team also include experts at the forefront of efforts to standardize and modernize health and cognitive assessments using state-of-the-art psychometric and computing approaches. Our application will: 1) harmonize and co-calibrate the cognitive assessments in the HRS family of studies, 2) identify limits of the validity of the measures, 3) and make concrete recommendations for future work and instrument development. We will accomplish these goals my making use of HRS and ISS, as well as other existing studies that include brief mental status assessments, neuropsychological tests, and relevant clinical outcomes for cognitive aging and dementia (neuroimaging, neuropathology, and longitudinal course).