Psychometric Integrative Technology for Cognitive Health Research

 描述(由申请人提供)：许多在美国境外进行的老年人健康和认知调查是仿照美国健康和退休研究(HRS)进行的。这些国际姐妹研究(ISS)中的每一个都使用不同的方法来评估认知功能。这些差异，再加上参与者的环境、语言、人口和健康特征的差异，使得很难就跨国认知障碍水平的相似和差异得出明确的结论。政策制定者和公共卫生领导人感兴趣的是，能够在国际上比较痴呆症和更广泛的认知障碍的比率。卫生部要求提供关于老年公民认知障碍相对负担和潜在影响的可靠信息，以评估以前的公众反应和未来应对人口结构变化的计划。我们的团队是一个富有成效的多学科小组，代表了认知衰老、心理测量学、神经心理学、医学、老年学和流行病学方面的专业知识。我们在这些领域有着长期的合作记录，并在HRS国际SISTER研究方面拥有广泛的应用经验，包括与当前应用直接相关的心理测量学联系研究。我们团队的成员还包括使用最先进的心理测量和计算方法将健康和认知评估标准化和现代化的前沿专家。我们的应用将：1)协调和共同校准HRS系列研究中的认知评估，2)确定测量的有效性限制，3)为未来的工作和工具开发提出具体建议。我们将通过使用HRS和ISS以及其他现有的研究来实现这些目标，这些研究包括简要的精神状态评估、神经心理学测试以及认知老化和痴呆的相关临床结果(神经成像、神经病理学和纵向病程)。

 DESCRIPTION (provided by applicant): A number of surveys of health and cognition in older adults conducted outside of the US are modeled after the US Health and Retirement Study (HRS). Each of these international sister studies (ISS) uses different methods to assess cognitive functioning. These differences, combined with differences in the environment, languages, demographic and health characteristics of the participants make it difficult to draw clear conclusions regarding similarities and differences in the level of cognitive impairment cross-nationally. The ability to compare rates of dementia and more broadly cognitive impairment internationally is of interest to policy makers and public health leaders. Health ministries require reliable information regarding the comparative burden and potential impact of cognitive impairment among their older citizens to evaluate previous public responses and plans for future responses to demographic shifts. Our team is a productive and multidisciplinary group representing expertise in cognitive aging, psychometrics, neuropsychology, medicine, gerontology, and epidemiology. We have a long track record of collaboration in these areas, and extensive applied experience with the HRS international sister studies, including psychometric linking studies with direct relevance to the current application. Members of our team also include experts at the forefront of efforts to standardize and modernize health and cognitive assessments using state-of-the-art psychometric and computing approaches. Our application will: 1) harmonize and co-calibrate the cognitive assessments in the HRS family of studies, 2) identify limits of the validity of the measures, 3) and make concrete recommendations for future work and instrument development. We will accomplish these goals my making use of HRS and ISS, as well as other existing studies that include brief mental status assessments, neuropsychological tests, and relevant clinical outcomes for cognitive aging and dementia (neuroimaging, neuropathology, and longitudinal course).