Imaging Stimulant Effects on Emotional Lability in Children with ADHD

影像学刺激对多动症儿童情绪不稳定的影响

• 批准号: 9119615
• 负责人: Jonathan E Posner
• 金额: $ 51.73万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-16 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119615
• 关键词: Address; Affect; Affective; Age; Amygdaloid structure; Anterior; Attention deficit hyperactivity disorder; Attenuated; Automobile Driving; Basal Ganglia; Behavioral; Biological Neural Networks; Brain; Child; Childhood; Clinical; Clinical Trials; Cognitive; Development; Diffusion Magnetic Resonance Imaging; Disease; Dissociation; Dorsal; Educational Status; Emotional; Functional Magnetic Resonance Imaging; Functional disorder; Hippocampus (Brain); Hyperactive behavior; Image; Impairment; Imprisonment; Impulsivity; Insula of Reil; Knowledge; MRI Scans; Magnetic Resonance Imaging; Measures; Mediator of activation protein; Modality; Motor Cortex; Neurobiology; Outcome; Participant; Patients; Performance; Perfusion; Pharmaceutical Preparations; Placebos; Play; Population; Prefrontal Cortex; Process; Psychiatry; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Research; Rest; School-Age Population; Spin Labels; Structure; Structure of supramarginal gyrus; Symptoms; Testing; Therapeutic; Underemployment; Youth; base; behavior measurement; clinical effect; cognitive control; cohort; effective therapy; emotion regulation; emotional stimulus; executive function; improved; inattention; neurobiological mechanism; neuroimaging; psychostimulant; public health relevance; reduce symptoms; response; social; stem

DESCRIPTION (provided by applicant): Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common disorders in pediatric psychiatry affecting 3-8% of school age children. Although ADHD is primarily characterized by inattention, hyperactivity and impulsivity, emotional lability is a common and impairing symptom in this population. Little is known, however, about the neurobiological substrates that underlie emotional lability in children with ADHD. Moreover, psychostimulants, the first-line treatment of ADHD, are known to reduce ADHD symptoms including emotional lability, yet the neurobiological mechanisms by which psychostimulants have their salutary effects upon emotional lability have scarcely been studied. To address this knowledge gap, we propose to conduct a longitudinal, multimodal MRI study to examine the effects of psychostimulants on the brain's affective network in children with ADHD. We will combine a multimodal MRI study with a randomized clinical trial of the psychostimulant lisdexamfetamine such that study participants will have an MRI scan prior to treatment and then a second MRI scan after 12 weeks of treatment with either lisdexamfetamine or placebo. The study will advance our knowledge of the neurobiology underlying emotional lability in children with ADHD, as well as the mechanism by which psychostimulants alleviate this symptom. Advancing this type of knowledge is critical for several reasons, but most importantly a clearer understanding of the neurobiological mechanisms by which psychostimulants are effective will promote the development of more effective and targeted treatments, as well as advance our understand of the pathophysiology of ADHD.

描述（由申请人提供）：注意力缺陷/多动障碍（ADHD）是儿科精神病学中最常见的疾病之一，影响3-8%的学龄儿童。虽然ADHD的主要特征是注意力不集中、多动和冲动，但情绪不稳定是这一人群中常见的损害性症状。然而，关于ADHD儿童情绪不稳定的神经生物学基础知之甚少。此外，精神兴奋剂，ADHD的一线治疗，已知减少ADHD症状，包括情绪不稳定，但精神兴奋剂对情绪不稳定的有益影响的神经生物学机制几乎没有研究。为了解决这一知识差距，我们建议进行纵向，多模态MRI研究，以检查精神兴奋剂对ADHD儿童大脑情感网络的影响。我们将联合收割机将多模式MRI研究与精神兴奋剂利右苯丙胺的随机临床试验结合起来，以便研究参与者在治疗前进行MRI扫描，然后在利右苯丙胺或安慰剂治疗12周后进行第二次MRI扫描。这项研究将推进我们对ADHD儿童情绪不稳定的神经生物学基础以及精神兴奋剂缓解这种症状的机制的认识。推进这类知识是至关重要的，原因有几个，但最重要的是，更清楚地了解精神兴奋剂有效的神经生物学机制将促进更有效和有针对性的治疗方法的发展，以及推进我们对ADHD病理生理学的理解。