Imaging Stimulant Effects on Emotional Lability in Children with ADHD

影像学刺激对多动症儿童情绪不稳定的影响

• 批准号: 9119615
• 负责人: Jonathan E Posner
• 金额: $ 51.73万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-16 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119615
• 关键词: Address; Affect; Affective; Age; Amygdaloid structure; Anterior; Attention deficit hyperactivity disorder; Attenuated; Automobile Driving; Basal Ganglia; Behavioral; Biological Neural Networks; Brain; Child; Childhood; Clinical; Clinical Trials; Cognitive; Development; Diffusion Magnetic Resonance Imaging; Disease; Dissociation; Dorsal; Educational Status; Emotional; Functional Magnetic Resonance Imaging; Functional disorder; Hippocampus (Brain); Hyperactive behavior; Image; Impairment; Imprisonment; Impulsivity; Insula of Reil; Knowledge; MRI Scans; Magnetic Resonance Imaging; Measures; Mediator of activation protein; Modality; Motor Cortex; Neurobiology; Outcome; Participant; Patients; Performance; Perfusion; Pharmaceutical Preparations; Placebos; Play; Population; Prefrontal Cortex; Process; Psychiatry; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Research; Rest; School-Age Population; Spin Labels; Structure; Structure of supramarginal gyrus; Symptoms; Testing; Therapeutic; Underemployment; Youth; base; behavior measurement; clinical effect; cognitive control; cohort; effective therapy; emotion regulation; emotional stimulus; executive function; improved; inattention; neurobiological mechanism; neuroimaging; psychostimulant; public health relevance; reduce symptoms; response; social; stem

DESCRIPTION (provided by applicant): Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common disorders in pediatric psychiatry affecting 3-8% of school age children. Although ADHD is primarily characterized by inattention, hyperactivity and impulsivity, emotional lability is a common and impairing symptom in this population. Little is known, however, about the neurobiological substrates that underlie emotional lability in children with ADHD. Moreover, psychostimulants, the first-line treatment of ADHD, are known to reduce ADHD symptoms including emotional lability, yet the neurobiological mechanisms by which psychostimulants have their salutary effects upon emotional lability have scarcely been studied. To address this knowledge gap, we propose to conduct a longitudinal, multimodal MRI study to examine the effects of psychostimulants on the brain's affective network in children with ADHD. We will combine a multimodal MRI study with a randomized clinical trial of the psychostimulant lisdexamfetamine such that study participants will have an MRI scan prior to treatment and then a second MRI scan after 12 weeks of treatment with either lisdexamfetamine or placebo. The study will advance our knowledge of the neurobiology underlying emotional lability in children with ADHD, as well as the mechanism by which psychostimulants alleviate this symptom. Advancing this type of knowledge is critical for several reasons, but most importantly a clearer understanding of the neurobiological mechanisms by which psychostimulants are effective will promote the development of more effective and targeted treatments, as well as advance our understand of the pathophysiology of ADHD.

描述(申请人提供)：注意力缺陷/多动障碍(ADHD)是儿科精神病学中最常见的疾病之一，影响3-8%的学龄儿童。虽然ADHD的主要特征是注意力不集中、多动和冲动，但情绪不稳定在这一人群中是一种常见的、有害的症状。然而，人们对ADHD儿童情绪不稳定的神经生物学基础知之甚少。此外，精神刺激剂是ADHD的一线治疗药物，众所周知可以减少包括情绪不稳定在内的ADHD症状，但精神刺激剂对情绪不稳定的有益作用的神经生物学机制几乎没有研究过。为了解决这一知识差距，我们建议进行一项纵向的多模式磁共振研究，以检查精神刺激剂对ADHD儿童大脑情感网络的影响。我们将结合多模式核磁共振研究和精神刺激剂左旋糖胺的随机临床试验，以便研究参与者在治疗前进行核磁共振扫描，然后在使用左旋糖胺或安慰剂治疗12周后进行第二次核磁共振扫描。这项研究将促进我们对ADHD儿童情绪不稳定背后的神经生物学以及精神刺激剂缓解这一症状的机制的了解。促进这类知识的发展是至关重要的，原因有几个，但最重要的是，更清楚地了解精神刺激剂有效的神经生物学机制将促进更有效和更有针对性的治疗方法的发展，以及促进我们对ADHD病理生理学的理解。