Special Mouse Strains Resource

 描述（由申请人提供）：总体组成许多常见疾病，包括最普遍的疾病，是遗传复杂的;也就是说，它们是多个遗传基因座的顶点，并受到发育和环境因素的影响。代谢途径在遗传上也很复杂，导致个体化的药物反应。通过复杂的性状分析来利用这种复杂性是个性化医疗的基础。特殊小鼠品系资源（SMSR）的总体目标是为遗传复杂性状的分析提供生物资源。该资源目前维持和分发六个重组近交系（RI）和两个染色体置换（CS）菌株集，这些菌株集来自高屏障动物饲养设施中维持的活菌落以及冷冻保存的胚胎和精子。SMSR将继续保存和确保提供专门的小鼠品系和复杂性状分析工具。SMSR还将与复杂性状群体密切合作，以评估和应对资源需求，进行推广，并提供大规模育种和表型分析的设施。

 DESCRIPTION (provided by applicant): Overall Component Many common diseases, including the most pervasive, are genetically complex; that is, they are the culmination of multiple genetic loci and are influenced by developmental and environmental factors. Metabolic pathways are also genetically complex, leading to individualized drug responses. Harnessing this complexity through complex trait analysis is the basis of personalized medicine. The overall goal of the Special Mouse Strains Resource (SMSR) is to provide biological resources for analysis of genetically complex traits. The resource currently maintains and distributes six recombinant inbred (RI) and two chromosome substitution (CS) strain sets from live colonies maintained in high barrier vivarium facilities and from cryopreserved embryos and sperm. The SMSR will continue to preserve and ensure the availability of specialized mouse strains and tools for complex trait analysis. The SMSR will also work closely with the complex trait community to assess and respond to resource needs, perform outreach and provide access to facilities for large-scale breeding and phenotyping.