Special Mouse Strains Resource

 说明(申请人提供)：总体构成许多常见疾病，包括最普遍的疾病，在基因上是复杂的；也就是说，它们是多个遗传位点的结果，并受到发育和环境因素的影响。代谢途径在遗传上也是复杂的，导致了个性化的药物反应。通过复杂的特征分析来驾驭这种复杂性是个性化医学的基础。特殊小鼠品系资源(SMSR)的总体目标是为遗传复杂性状的分析提供生物资源。该资源库目前维护和分发了6个重组近交系(RI)和2个染色体替代(CS)菌株集，这些菌株来自高屏障隔膜设施中的活菌落以及冷冻保存的胚胎和精子。SMSR将继续保存和确保专门的小鼠品系和工具的可用性，以进行复杂的特征分析。SMSR还将与复杂性状社区密切合作，评估和回应资源需求，开展外联活动，并为大规模育种和表型鉴定提供设施。

 DESCRIPTION (provided by applicant): Overall Component Many common diseases, including the most pervasive, are genetically complex; that is, they are the culmination of multiple genetic loci and are influenced by developmental and environmental factors. Metabolic pathways are also genetically complex, leading to individualized drug responses. Harnessing this complexity through complex trait analysis is the basis of personalized medicine. The overall goal of the Special Mouse Strains Resource (SMSR) is to provide biological resources for analysis of genetically complex traits. The resource currently maintains and distributes six recombinant inbred (RI) and two chromosome substitution (CS) strain sets from live colonies maintained in high barrier vivarium facilities and from cryopreserved embryos and sperm. The SMSR will continue to preserve and ensure the availability of specialized mouse strains and tools for complex trait analysis. The SMSR will also work closely with the complex trait community to assess and respond to resource needs, perform outreach and provide access to facilities for large-scale breeding and phenotyping.