Data Management, Analysis and Resources Dissemination Core (DMARD)

数据管理、分析和资源传播核心 (DMARD)

• 批准号: 9032442
• 负责人: Granger Gideon Sutton
• 金额: $ 123.18万
• 依托单位: J. CRAIG VENTER INSTITUTE, INC.
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9032442
• 关键词: Archives; Bioinformatics; Biotechnology; Clinical Data; Communicable Diseases; Communities; Data; Data Analyses; Data Quality; Deposition; Funding; Galaxy; Genbank; Generations; Genome; Genomics; Guidelines; Infection; Informatics; Institutes; Laboratories; Management Information Systems; Metadata; National Institute of Allergy and Infectious Disease; Ontology; Process; Program Research Project Grants; Protocols documentation; Public Domains; Publications; Reading; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Scientist; Services; Single Nucleotide Polymorphism; Statistical Methods; System; Technology; Training Programs; United States National Institutes of Health; Validation; Work; application programming interface; base; biodefense; community center; computerized data processing; cost effective; data integration; data management; data sharing; genome sequencing; high throughput analysis; microbial; open source; programs; repository; software as a service; success; tool; virtual; web interface; web site

The Data Management, Analysis and Resources Dissemination Core (DMARD) will support all four Research Projects and the Technology Core by providing rapid, accurate and cost-effective data management, high throughput analysis and resource sharing and dissemination according to the Resource Sharing Plan. DMARD Core functions will be divided into three primary responsibilities; resource sharing, comprehensive data management and infrastructure to support high throughput analysis. Our GCID Program will rapidly release, pre-publication genomic and other data including metadata as detailed in the Resource Sharing Plan. Raw genome sequence will be submitted as rapidly as possible not exceeding 45 days from generation and data quality check to either the Trace Archive or, as appropriate, to the Short Read Archive at NCBI/NLM/NIH. Full and partial genome assemblies will be deposited in GenBank at NCBl after verification, no later than 45 days of being generated, followed by release to other web sites, as approved by NIAID. Single nucleotide polymorphisms (SNP) generated as part of the project, will be submitted as rapidly as possible to NCBl dbSNP and not later than 45 days from validation. Clinical data and other metadata will be deposited to the appropriate NIAID funded Bioinformatics Resource Centers or other public resources as appropriate. Metadata formats developed through the NIAID GSC-BRC collaborative efforts will be employed. Microbial strains employed in the JCVI GCID will be deposited to the NIAID BEI (Biodefense & Emerging Infections Research Resources Repository) or other approved public repositories. Informatics tools developed within the Program for processing or analyzing the data generated in the course of performing the Program's Research Projects will be placed in the public domain via SourceForge as open source. The DMARD will provide comprehensive data management for tracking metadata, samples, reagents, and data. The DMARD will work with Technology Core to provide Galaxy and Kepler based modular infrastructure for integrative analysis and interpretation. The DMARD will work with the Technology Core to provide ready to use tools and pipelines to the research community.

数据管理、分析和资源传播核心（DMARD）将支持所有四个 通过提供快速、准确和具有成本效益的数据来研究项目和技术核心 根据资源进行管理、高通量分析以及资源共享和传播 共享计划。 DMARD 核心职能将分为三个主要职责；资源共享， 全面的数据管理和基础设施支持高通量分析。我们的GCID 计划将快速发布出版前的基因组数据和其他数据，包括元数据，详见 资源共享计划。原始基因组序列将尽快提交，不超过 45 从生成和数据质量检查到跟踪存档或根据情况到短文件的天数 阅读 NCBI/NLM/NIH 的存档。完整和部分基因组组装将存放在 NCBl 的 GenBank 中 验证后，不晚于生成后45天，然后发布到其他网站，如 经NIAID批准。作为该项目的一部分产生的单核苷酸多态性（SNP）将被 尽快且不晚于验证后 45 天提交给 NCBl dbSNP。临床数据 和其他元数据将存放到适当的 NIAID 资助的生物信息学资源中心或 其他适当的公共资源。通过 NIAID GSC-BRC 开发的元数据格式 将采取协作努力。 JCVI GCID 中使用的微生物菌株将存放在 NIAID BEI（生物防御和新发感染研究资源库）或其他经批准的公共资源库 存储库。本计划内开发的信息学工具，用于处理或分析生成的数据 在执行该计划的过程中，研究项目将通过以下方式置于公共领域： SourceForge 作为开源软件。 DMARD 将为跟踪提供全面的数据管理 元数据、样品、试剂和数据。 DMARD 将与 Technology Core 合作，提供 Galaxy 和 基于开普勒的模块化基础设施，用于综合分析和解释。 DMARD 将与 技术核心为研究界提供现成的工具和管道。