Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure

描述(由申请人提供)：这项由研究人员领导的新的纵向研究是为了回应(PA-11-104)，并将检查：(1)遗传和心理环境因素(歧视、抑郁和育儿行为)对3至5岁非裔美国人(AA)儿童健康的影响，(2)AA妇女和儿童中GxE患高血压(HTN)的风险。这个项目的总体目标是描绘心理生物学(GxE交互作用)机制，通过这些机制，AA母亲的种族歧视、心理健康和育儿行为会随着时间的推移影响她们自己和他们年幼的孩子的血压(BP)。我们的研究将检验遗传(候选基因和表观遗传效应)和心理(母亲感知的种族歧视、心理健康和育儿行为)交互作用对这一人群的BP的影响。我们将采用心理生物学的方法：利用纵向队列研究设计的心理和生物学评估，两步候选基因和表观遗传学方法，以及使用祖先信息标记来解释人口分层混合体，以探索GxE在AA母亲和儿童中对BP的交互作用。这项研究的数据分析将使用多种混合建模、交叉验证和错误发现率方法。我们将招收250名3至5岁的再生障碍性贫血儿童及其母亲/母亲照顾者。我们将在两年内每六个月评估一次母子因素。我们提出如下建议：目标1：在两年的时间里，检验母亲感知的种族歧视的GxE交互作用和表观遗传效应及其对BP的影响。目的2：在两年的时间里检验母亲心理健康状况[抑郁症状]的GxE交互作用和表观遗传效应及其对血压的影响。目的3：研究母亲育儿行为的GxE交互作用和表观遗传效应及其对血压的影响。我们的项目支持NINR的使命，通过对妇女和儿童的健康和疾病进行基础研究，促进和改善个人、家庭、社区和人口的健康。这项拟议的研究通过整合生物学(遗传学)和行为(心理学)成分来扩展护理科学，这些成分可以提供多层次因素的组合，这些因素有助于AAS在美国具有最高的HTN发病率。我们项目的发现有助于开发针对遗传和心理因素的干预措施，以降低HTN的这些风险。

DESCRIPTION (provided by applicant): This resubmission of a NEW INVESTIGATOR led longitudinal study is in response to (PA-11-104) and will examine: (1) the impact of (GXE) genetic and psychological environmental factors (discrimination, depression, and parenting behaviors) on the health of African American (AA) children aged 3 through 5 years and (2) the GXE risk for hypertension (HTN) in AA women and children. The overall goal of this project is to delineate the psychobiological (GXE interaction) mechanisms through which AA mothers' perceived racial discrimination, mental health, and parenting behavior affect their own and their young children's blood pressure (BP) over time. Our research will examine both genetic (candidate gene and epigenetic effects) and psychological (maternal perceived racial discrimination, mental health, and parenting behavior) interaction effects on BP on this population. We will employ a psychobiological approach by: utilizing psychological and biological assessments using a longitudinal cohort research design, a 2-step candidate gene and epigenetic methodology, and use of ancestry informative markers to account for population stratification admixture to explore GXE interactions on BP in AA mothers and children. Data analysis for the study will be conducted using multiple mixed modeling, cross-validation, and false discovery rate methods. We will enroll 250 AA children aged 3 through 5 years and their (n=250) mothers/maternal caregivers. We will assess mother and child factors every six months for 2 years. We propose the following: Aim 1: Examine the GXE interaction and epigenetic effects of mothers' perceived racial discrimination and its influence on BP over a period of two years. Aim 2: Examine the GXE interaction and epigenetic effects of mothers' mental health status [symptoms of depression] and its influence on BP over a period of two years. Aim 3: Examine the GXE interaction and epigenetic effects of mothers' parenting behavior and its influence on BP over a period of two years. Our project supports NINR's mission "to promote and improve the health of individuals, families, communities, and populations" by conducting basic research on the health and illness of women and young children. The proposed research extends nursing science by integrating the biological (genetics) and behavioral (psychology) components that can inform the combination of multi-level factors that contribute to AAs having the highest incidence of HTN in the US. Findings from our project can contribute to developing interventions that address genetic and psychological factors to reduce these risks for HTN.