Genetic Contributions to Smoking and Internalizing Problems in Adolescence

青少年吸烟和内化问题的遗传因素

• 批准号: 9322325
• 负责人: Cristina B. Bares
• 金额: $ 14.58万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9322325
• 关键词: 17 year old; Adolescence; Adolescent; Adolescent Development; Adult; Age of Onset; Anxiety; Behavior; Behavioral; Behavioral Genetics; Child Development; Cigarette; Complex; Data; Data Collection; Data Set; Development; Ecological momentary assessment; Environment; Environmental Risk Factor; Etiology; Family Study; Genes; Genetic; Genetic Models; Genetic Risk; Genotype; Goals; Growth; Health; Heritability; Individual; Institutes; K-Series Research Career Programs; Knowledge; Learning; Longitudinal Studies; Measures; Mediating; Mental Depression; Mental Health; Mentors; Methodology; Methods; Minnesota; Modeling; Molecular Genetics; Moods; National Institute of Drug Abuse; National Longitudinal Survey of Adolescent to Adult Health; Nicotine Dependence; Participant; Pathway interactions; Pharmaceutical Preparations; Phenotype; Pilot Projects; Prevalence; Preventive Intervention; Problem behavior; Public Health; Quantitative Genetics; Recruitment Activity; Registries; Research; Research Project Grants; Research Training; Risk; Risk Factors; Role; Sampling; Science; Smoke; Smoking; Smoking Behavior; Sum; Symptoms; Testing; Time; Training; Training Activity; Twin Multiple Birth; Twin Studies; Universities; Variant; Virginia; adolescent smoking; anxiety symptoms; cost; critical period; depressive symptoms; design; deviant; emerging adult; genetic approach; genetic epidemiology; genetic variant; genome wide association study; insight; molecular marker; mortality; never smoker; peer; peer influence; population based; programs; prospective; psychogenetics; public health relevance; rare variant; risk variant; skills; smoking prevalence

DESCRIPTION (provided by applicant): This Career Development Award (K01) will provide the candidate with the necessary skills to develop an independent research program focused on integrating genetic methodologies to the candidate's already strong longitudinal modeling skills to explore and clarify the etiology of the interplay between cigarette use and internalizing problems during adolescence. Despite decreases in prevalence of smoking during adolescence in the past two decades, adolescence continues to be the developmental period of greatest risk for cigarette use onset and increase in internalizing problems. Clarifying the complex etiological pathways involved in the co-occurrence between cigarette use and internalizing problems during this vulnerable time requires using multiple methodologies. The overall aim of the current proposal is to test increasingly complex longitudinal models that explore the degree to which the co-occurrence between adolescent cigarette use and internalizing problems are influenced by genetic and environmental factors and to include measured genetic variants. The training plan will be completed at the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University and is designed to provide the candidate with skills in genetic epidemiology, quantitative genetics, and molecular genetics. The candidate will acquire the knowledge and skills to a) conduct univariate, bivariate, and multivariate genetically informed studies to identify the genetic and environmental risk factors in smoking initiation, progression t heavier smoking, nicotine dependence, and internalizing problems; b) conduct longitudinal genetically informed studies to clarify the causal pathways involved in cigarette use and internalizing problems by exploring the degree to which genetic and environmental factors explain the covariance between the behaviors; and c) conduct genetically informed ecological momentary assessment studies of adolescent twin pairs to explore the causal pathway between these problems behaviors. These skills will be developed through a combination of formal coursework, mentored research projects, and didactic training. The proposed research program involves a combination of analysis of existing longitudinal studies of adolescent twins and an original data collection pilot project. The existing longitudinal studies of adolescent twins inclue the Swedish Twin Study of Child and Adolescent Development, the Minnesota Twin and Family Study, the Virginia Twin Study of Adolescent Behavioral Development, the National Longitudinal Study of Adolescent Health, the GEDI (Genes, Environment, Development Initiative part of NIDA's Genetics Consortium). In the pilot project, the candidate will collect momentary cigarette use and mood data of 16- and 17-year-old adolescent twin pairs recruited from a population-based twin registry comprised of over 50,000 twins. Training activities and results will be used to develop a R01 proposal for a prospective momentary assessment and genotyping study of 14 to 17 year old adolescent twins.

描述（由申请人提供）：该职业发展奖（K 01）将为候选人提供必要的技能，以开发一个独立的研究计划，重点是将遗传学方法与候选人已经很强的纵向建模技能相结合，以探索和澄清青少年时期吸烟和内化问题之间相互作用的病因。尽管在过去的二十年中，青少年吸烟的流行率有所下降，但青少年仍然是吸烟发病和内化问题增加的最大风险的发育期。在这个脆弱的时期，要澄清吸烟和内化问题共同发生的复杂病因学途径，需要使用多种方法。目前建议的总体目标是测试越来越复杂的纵向模型，探讨青少年吸烟和内化问题之间的共同发生的遗传和环境因素的影响程度，并包括测量的遗传变异。培训计划将在弗吉尼亚联邦大学弗吉尼亚精神病学和行为遗传学研究所完成，旨在为候选人提供遗传流行病学，数量遗传学和分子遗传学方面的技能。候选人将获得以下知识和技能：a）进行单变量，双变量和多变量遗传信息研究，以确定吸烟开始，吸烟加重，尼古丁依赖和内化问题的遗传和环境风险因素; B）进行纵向遗传信息研究，通过探索遗传因素对吸烟的影响程度，和环境因素解释行为之间的协方差;以及c）对青少年双胞胎进行遗传信息生态瞬时评估研究，以探索这些问题行为之间的因果途径。这些技能将通过正式的课程，指导研究项目和教学培训相结合的发展。拟议的研究计划包括分析现有的青少年双胞胎的纵向研究和原始数据收集试点项目相结合。现有的青少年双胞胎纵向研究包括瑞典儿童和青少年发展双胞胎研究、明尼苏达州双胞胎和家庭研究、弗吉尼亚州青少年行为发展双胞胎研究、国家青少年健康纵向研究、GEDI（NIDA遗传学联盟的基因、环境、发展倡议部分）。在试点项目中，候选人将收集16岁和17岁青少年双胞胎的瞬时吸烟和情绪数据，这些双胞胎是从一个基于人口的双胞胎登记处招募的，该登记处由超过50，000对双胞胎组成。培训活动和成果将用于 为14至17岁青少年双胞胎的前瞻性瞬时评估和基因分型研究制定R 01提案。