Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics

新型涂层可最大限度地减少牙科陶瓷的表面降解和断裂敏感性

• 批准号: 9462414
• 负责人: Josephine F. Esquivel-Upshaw
• 金额: $ 15.74万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9462414
• 关键词: Alkalies; Beverages; Bite Force; Buffers; Ceramics; Chemical Warfare; Chemicals; Clinical; Clinical Research; Complex; Corrosion; Corrosives; Dental; Dental Enamel; Dental Porcelain; Dental Prosthesis; Dental Veneer Application; Dental caries; Dental crowns; Deposition; Diet; Effectiveness; Ensure; Environment; Esthetics; Exhibits; Failure; Fracture; Glass; Goals; In Vitro; Investments; Ions; Lead; Liquid substance; Macor; Mechanics; Methodology; Microscopy; Oral; Oral cavity; Outcome Study; Patients; Periodontal Diseases; Phase; Plasma Enhancement; Predisposition; Probability; Process; Property; Prosthesis; Public Health; Research; Research Project Grants; Resistance; Roentgen Rays; Saliva; Scanning Electron Microscopy; Secondary to; Spectrum Analysis; Surface; Technology; Testing; Thinness; Translational Research; Variant; biomaterial compatibility; ceramic restoration; design; digital; fracture risk; improved; in vitro testing; novel; programs; protective effect; protective efficacy; restorative dentistry; simulation; vapor

PROJECT SUMMARY/ABSTRACT This proposal is focused on establishing the efficacy of protective coatings in minimizing surface degradation of glass-ceramic veneers as well as minimizing chipping of ceramic-ceramic prostheses. This R01 proposal is designed to analyze the chemical durability and fracture resistance of three glass-ceramic veneering materials with different microstructures through in vitro simulation tests and to determine whether a novel pH cycling methodology will reliably simulate the chemical degradation that is controlled by pH fluctuations in the oral environment. The long-term goal of this research program is to develop fracture-resistant and chemically stable (durable), dental ceramic coatings for veneered dental ceramic prostheses. The central hypothesis of this project is that dental ceramic veneers will sustain minimal surface degradation and maintain or increase their apparent strength when coated with an optimized protective, adherent surface layer. This unique, translational research project will apply corrosion testing and damage analysis of ceramic veneering materials through in vitro simulation. We will employ a novel pH cycling methodology, which will apply three sequences of alternating pH buffer solutions from acidic to alkali, alongside intermittent abrasion. This cycling mechanism effectively simulates the fluctuating pH levels of oral fluids and can more accurately test chemical durability of ceramic materials. More importantly, we will establish the effectiveness of optimized protective coatings deposited using plasma enhanced coating vapor deposition technology in minimizing ceramic corrosion and improving fracture resistance. We will analyze the surface composition and topographical changes using x-ray photoelectron spectroscopy (XPS), environmental scanning electron microscopy (ESEM), energy dispersive x-ray analysis (EDAX), digital microscopy, and 3D laserscanning for wear analysis. We propose the following aims to test our central hypothesis: Aim 1: Test the hypothesis that glass-ceramic veneers undergo an alternating dissolution process (selective leaching and total dissolution) as a function of cycling pH environments resulting in compositional changes and rapid surface degradation of the glass phase; Aim 2: Test the hypothesis that a significant decrease in the biaxial flexural strength of glass- ceramic veneers will occur as a result of a simulated oral environment of alternating low and high pH or simulated occlusal forces with intermittent abrasion or a combination of both; Aim 3: Test the hypothesis that a protective coating can be optimized to achieve good resistance to low pH and high pH environments, ideal bonding to the ceramic substrate, good abrasion and fracture resistance and proper esthetics; Aim 4: Test the hypothesis that the optimal protective coating will significantly decrease the in vitro corrosive rate of glass- ceramic veneers as evidenced by a reduction in surface compositional changes caused by fluctuations in pH and abrasion factors, and maintain or significantly increase their “apparent” biaxial flexural strength.

项目概要/摘要 该提案的重点是确定保护涂层在最大限度地减少表面退化方面的功效 glass-ceramic veneers as well as minimizing chipping of ceramic-ceramic prostheses. This R01 proposal is 旨在分析三种微晶玻璃贴面材料的化学耐久性和抗断裂性 通过体外模拟测试具有不同的微观结构并确定是否具有新颖的pH循环 该方法将可靠地模拟由口腔中 pH 值波动控制的化学降解 环境。 The long-term goal of this research program is to develop fracture-resistant and chemically stable (durable), dental ceramic coatings for veneered dental ceramic prostheses.这个假设的中心假设 项目的目标是牙科陶瓷贴面将维持最小的表面退化并保持或增加其 apparent strength when coated with an optimized protective, adherent surface layer. This unique, translational research project will apply corrosion testing and damage analysis of ceramic 通过体外模拟饰面材料。 We will employ a novel pH cycling methodology, which will 使用三个顺序交替的 pH 缓冲溶液（从酸性到碱性），同时进行间歇性磨损。 这种循环机制有效模拟了口腔液pH值的波动，可以更准确地 测试陶瓷材料的化学耐久性。 More importantly, we will establish the effectiveness of optimized 使用等离子增强涂层气相沉积技术沉积的保护涂层，最大限度地减少 陶瓷腐蚀和提高抗断裂性能。我们将分析表面成分并 topographical changes using x-ray photoelectron spectroscopy (XPS), environmental scanning electron microscopy (ESEM), energy dispersive x-ray analysis (EDAX), digital microscopy, and 3D laserscanning for wear analysis. We propose the following aims to test our central hypothesis: Aim 1: Test the hypothesis that glass-ceramic veneers undergo an alternating dissolution process (selective leaching and total dissolution) as a function of cycling pH environments resulting in compositional changes and rapid surface degradation of the glass phase; Aim 2: Test the hypothesis that a significant decrease in the biaxial flexural strength of glass- ceramic veneers will occur as a result of a simulated oral environment of alternating low and high pH or simulated occlusal forces with intermittent abrasion or a combination of both;目标 3：检验假设 protective coating can be optimized to achieve good resistance to low pH and high pH environments, ideal bonding to the ceramic substrate, good abrasion and fracture resistance and proper esthetics; Aim 4: Test the hypothesis that the optimal protective coating will significantly decrease the in vitro corrosive rate of glass- ceramic veneers as evidenced by a reduction in surface compositional changes caused by fluctuations in pH and abrasion factors, and maintain or significantly increase their “apparent” biaxial flexural strength.