Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics

新型涂层可最大限度地减少牙科陶瓷的表面降解和断裂敏感性

• 批准号: 9462414
• 负责人: Josephine F. Esquivel-Upshaw
• 金额: $ 15.74万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9462414
• 关键词: Alkalies; Beverages; Bite Force; Buffers; Ceramics; Chemical Warfare; Chemicals; Clinical; Clinical Research; Complex; Corrosion; Corrosives; Dental; Dental Enamel; Dental Porcelain; Dental Prosthesis; Dental Veneer Application; Dental caries; Dental crowns; Deposition; Diet; Effectiveness; Ensure; Environment; Esthetics; Exhibits; Failure; Fracture; Glass; Goals; In Vitro; Investments; Ions; Lead; Liquid substance; Macor; Mechanics; Methodology; Microscopy; Oral; Oral cavity; Outcome Study; Patients; Periodontal Diseases; Phase; Plasma Enhancement; Predisposition; Probability; Process; Property; Prosthesis; Public Health; Research; Research Project Grants; Resistance; Roentgen Rays; Saliva; Scanning Electron Microscopy; Secondary to; Spectrum Analysis; Surface; Technology; Testing; Thinness; Translational Research; Variant; biomaterial compatibility; ceramic restoration; design; digital; fracture risk; improved; in vitro testing; novel; programs; protective effect; protective efficacy; restorative dentistry; simulation; vapor

PROJECT SUMMARY/ABSTRACT This proposal is focused on establishing the efficacy of protective coatings in minimizing surface degradation of glass-ceramic veneers as well as minimizing chipping of ceramic-ceramic prostheses. This R01 proposal is designed to analyze the chemical durability and fracture resistance of three glass-ceramic veneering materials with different microstructures through in vitro simulation tests and to determine whether a novel pH cycling methodology will reliably simulate the chemical degradation that is controlled by pH fluctuations in the oral environment. The long-term goal of this research program is to develop fracture-resistant and chemically stable (durable), dental ceramic coatings for veneered dental ceramic prostheses. The central hypothesis of this project is that dental ceramic veneers will sustain minimal surface degradation and maintain or increase their apparent strength when coated with an optimized protective, adherent surface layer. This unique, translational research project will apply corrosion testing and damage analysis of ceramic veneering materials through in vitro simulation. We will employ a novel pH cycling methodology, which will apply three sequences of alternating pH buffer solutions from acidic to alkali, alongside intermittent abrasion. This cycling mechanism effectively simulates the fluctuating pH levels of oral fluids and can more accurately test chemical durability of ceramic materials. More importantly, we will establish the effectiveness of optimized protective coatings deposited using plasma enhanced coating vapor deposition technology in minimizing ceramic corrosion and improving fracture resistance. We will analyze the surface composition and topographical changes using x-ray photoelectron spectroscopy (XPS), environmental scanning electron microscopy (ESEM), energy dispersive x-ray analysis (EDAX), digital microscopy, and 3D laserscanning for wear analysis. We propose the following aims to test our central hypothesis: Aim 1: Test the hypothesis that glass-ceramic veneers undergo an alternating dissolution process (selective leaching and total dissolution) as a function of cycling pH environments resulting in compositional changes and rapid surface degradation of the glass phase; Aim 2: Test the hypothesis that a significant decrease in the biaxial flexural strength of glass- ceramic veneers will occur as a result of a simulated oral environment of alternating low and high pH or simulated occlusal forces with intermittent abrasion or a combination of both; Aim 3: Test the hypothesis that a protective coating can be optimized to achieve good resistance to low pH and high pH environments, ideal bonding to the ceramic substrate, good abrasion and fracture resistance and proper esthetics; Aim 4: Test the hypothesis that the optimal protective coating will significantly decrease the in vitro corrosive rate of glass- ceramic veneers as evidenced by a reduction in surface compositional changes caused by fluctuations in pH and abrasion factors, and maintain or significantly increase their “apparent” biaxial flexural strength.

项目摘要/摘要 该提案的重点是确定保护涂层以最大程度地减少表面降解的有效性 玻璃陶瓷饰面，并最大程度地减少陶瓷陶瓷假体的碎屑。这个R01提案是 旨在分析三种玻璃陶瓷材料的化学耐用性和抗断裂性 通过体外模拟测试与不同的微观结构，并确定新型pH循环是否 方法学将可靠地模拟由口腔中pH波动控制的化学降解 环境。该研究计划的长期目标是开发抗裂缝和化学稳定的 （耐用），牙科陶瓷涂料，用于备用牙科陶瓷假体。中心假设 项目是，牙科陶瓷贴面将维持最小的表面降解，并维持或增加其 当用优化的保护性，粘合表面层涂层时，明显的强度。 这个独特的翻译研究项目将应用陶瓷腐蚀测试和损坏分析 通过体外模拟进行饰面材料。我们将采用一种新颖的pH骑行方法，该方法将 在间歇性的磨损以及间歇性的磨损外，应用三个改变pH缓冲溶液从酸性到碱的序列。 这种循环机制有效地模拟了口服流体的波动pH值，并且可以更准确 测试陶瓷材料的化学耐用性。更重要的是，我们将确定优化的有效性 使用等离子体增强涂料蒸气沉积技术沉积的保护涂层，以最大程度地减少 陶瓷腐蚀和改善断裂抗性。我们将分析表面组成和 使用X射线光电子光谱（XP），环境扫描电子设备的地形变化 显微镜（ESEM），能量色散X射线分析（EDAX），数字显微镜和3D LaserScanning用于 我们提出以下旨在检验我们的中心假设的目的：目标1：检验以下假设。 玻璃陶瓷贴面经历替代溶解过程（选择性步行和总溶解） 循环pH环境的函数，导致复合变化和快速的表面降解 玻璃相；目标2：检验以下假设：玻璃双轴弯曲强度显着降低 陶瓷贴面将是由于替代低pH和高pH和高pH和高pH或高的口服环境而发生的 模拟咬合力，间歇性磨损或两者的组合；目标3：检验一个假设 可以优化保护性涂层，以实现对低pH和高pH环境的良好耐药性，理想 与陶瓷底物粘合，良好的磨损和断裂耐药性和适当的美学；目标4：测试 假设最佳保护涂层将显着降低玻璃的体外腐蚀速率 陶瓷贴面是由pH波动引起的表面组成变化的减少所证明的 和磨损因素，并保持或显着增加其“明显”双轴弯曲强度。