Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics

新型涂层可最大限度地减少牙科陶瓷的表面降解和断裂敏感性

• 批准号: 9462414
• 负责人: Josephine F. Esquivel-Upshaw
• 金额: $ 15.74万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9462414
• 关键词: Alkalies; Beverages; Bite Force; Buffers; Ceramics; Chemical Warfare; Chemicals; Clinical; Clinical Research; Complex; Corrosion; Corrosives; Dental; Dental Enamel; Dental Porcelain; Dental Prosthesis; Dental Veneer Application; Dental caries; Dental crowns; Deposition; Diet; Effectiveness; Ensure; Environment; Esthetics; Exhibits; Failure; Fracture; Glass; Goals; In Vitro; Investments; Ions; Lead; Liquid substance; Macor; Mechanics; Methodology; Microscopy; Oral; Oral cavity; Outcome Study; Patients; Periodontal Diseases; Phase; Plasma Enhancement; Predisposition; Probability; Process; Property; Prosthesis; Public Health; Research; Research Project Grants; Resistance; Roentgen Rays; Saliva; Scanning Electron Microscopy; Secondary to; Spectrum Analysis; Surface; Technology; Testing; Thinness; Translational Research; Variant; biomaterial compatibility; ceramic restoration; design; digital; fracture risk; improved; in vitro testing; novel; programs; protective effect; protective efficacy; restorative dentistry; simulation; vapor

PROJECT SUMMARY/ABSTRACT This proposal is focused on establishing the efficacy of protective coatings in minimizing surface degradation of glass-ceramic veneers as well as minimizing chipping of ceramic-ceramic prostheses. This R01 proposal is designed to analyze the chemical durability and fracture resistance of three glass-ceramic veneering materials with different microstructures through in vitro simulation tests and to determine whether a novel pH cycling methodology will reliably simulate the chemical degradation that is controlled by pH fluctuations in the oral environment. The long-term goal of this research program is to develop fracture-resistant and chemically stable (durable), dental ceramic coatings for veneered dental ceramic prostheses. The central hypothesis of this project is that dental ceramic veneers will sustain minimal surface degradation and maintain or increase their apparent strength when coated with an optimized protective, adherent surface layer. This unique, translational research project will apply corrosion testing and damage analysis of ceramic veneering materials through in vitro simulation. We will employ a novel pH cycling methodology, which will apply three sequences of alternating pH buffer solutions from acidic to alkali, alongside intermittent abrasion. This cycling mechanism effectively simulates the fluctuating pH levels of oral fluids and can more accurately test chemical durability of ceramic materials. More importantly, we will establish the effectiveness of optimized protective coatings deposited using plasma enhanced coating vapor deposition technology in minimizing ceramic corrosion and improving fracture resistance. We will analyze the surface composition and topographical changes using x-ray photoelectron spectroscopy (XPS), environmental scanning electron microscopy (ESEM), energy dispersive x-ray analysis (EDAX), digital microscopy, and 3D laserscanning for wear analysis. We propose the following aims to test our central hypothesis: Aim 1: Test the hypothesis that glass-ceramic veneers undergo an alternating dissolution process (selective leaching and total dissolution) as a function of cycling pH environments resulting in compositional changes and rapid surface degradation of the glass phase; Aim 2: Test the hypothesis that a significant decrease in the biaxial flexural strength of glass- ceramic veneers will occur as a result of a simulated oral environment of alternating low and high pH or simulated occlusal forces with intermittent abrasion or a combination of both; Aim 3: Test the hypothesis that a protective coating can be optimized to achieve good resistance to low pH and high pH environments, ideal bonding to the ceramic substrate, good abrasion and fracture resistance and proper esthetics; Aim 4: Test the hypothesis that the optimal protective coating will significantly decrease the in vitro corrosive rate of glass- ceramic veneers as evidenced by a reduction in surface compositional changes caused by fluctuations in pH and abrasion factors, and maintain or significantly increase their “apparent” biaxial flexural strength.

项目总结/摘要 该提案的重点是确定保护涂层在最大限度地减少表面降解方面的功效， 玻璃-陶瓷贴面以及最小化陶瓷-陶瓷假体的碎裂。此R 01提案是 旨在分析三种玻璃陶瓷饰面材料的化学耐久性和抗断裂性 通过体外模拟试验，以确定是否有新的pH循环 该方法将可靠地模拟受口腔中pH波动控制的化学降解， 环境这项研究计划的长期目标是开发出抗真菌和化学稳定的 （耐用），用于贴面牙科陶瓷修复体的牙科陶瓷涂层。这个问题的核心假设是 该项目是牙科陶瓷贴面将维持最小的表面降解，并保持或增加其 涂覆优化的保护性、粘附性表面层时的表观强度。 这一独特的转化研究项目将应用于陶瓷的腐蚀测试和损伤分析 体外模拟贴面材料。我们将采用一种新的pH循环方法， 应用三个顺序的交替pH缓冲溶液，从酸性到碱性，以及间歇性磨损。 这种循环机制有效地模拟了口腔液pH值的波动， 测试陶瓷材料的化学耐久性。更重要的是，我们将建立优化的有效性 使用等离子体增强涂层气相沉积技术沉积的保护涂层 陶瓷腐蚀和提高抗断裂性。我们将分析表面成分， 使用X射线光电子能谱（XPS）、环境扫描电子能谱（SEM） 电子显微镜（ESEM）、能量色散X射线分析（EDAX）、数字显微镜和3D激光扫描 磨损分析我们提出以下目标来检验我们的中心假设：目标1：检验假设， 玻璃陶瓷贴面经历交替溶解过程（选择性浸出和完全溶解）， 循环pH环境的功能，导致组成变化和快速的表面降解， 玻璃相;目的2：检验玻璃的双轴弯曲强度显著降低的假设， 陶瓷贴面将作为交替的低和高pH的模拟口腔环境的结果而出现， 模拟咬合力与间歇性磨损或两者的组合;目的3：测试假设， 保护涂层可以优化，以实现对低pH和高pH环境的良好耐受性， 结合到陶瓷基底上，良好的耐磨性和抗断裂性以及适当的美观性;目的4：测试 假设最佳保护涂层将显著降低玻璃的体外腐蚀速率- 陶瓷贴面，如通过由pH值波动引起的表面组成变化的减少所证明的 和磨损因子，并保持或显著增加它们的“表观”双轴弯曲强度。