Novel coatings to minimize surface degradation and fracture susceptibility of dental ceramics

新型涂层可最大限度地减少牙科陶瓷的表面降解和断裂敏感性

• 批准号: 9176145
• 负责人: Josephine F. Esquivel-Upshaw
• 金额: $ 65万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-13 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9176145
• 关键词: Alkalies; Beverages; Bite Force; Buffers; Ceramics; Chemical Warfare; Chemicals; Clinical; Clinical Research; Complex; Corrosion; Corrosives; Dental; Dental Enamel; Dental Porcelain; Dental Prosthesis; Dental caries; Dental crowns; Deposition; Diet; Effectiveness; Ensure; Environment; Esthetics; Exhibits; Failure; Fracture; Glass; Goals; In Vitro; Investments; Ions; Lead; Liquid substance; Macor; Mechanics; Methodology; Microscopy; Oral; Oral cavity; Outcome Study; Patients; Periodontal Diseases; Phase; Plasma; Predisposition; Probability; Process; Property; Prosthesis; Public Health; Research; Research Project Grants; Resistance; Risk; Saliva; Scanning Electron Microscopy; Secondary to; Spectrum Analysis; Surface; Technology; Testing; Translational Research; Variant; biomaterial compatibility; ceramic restoration; design; digital; improved; in vitro testing; novel; programs; protective effect; protective efficacy; restorative dentistry; simulation; vapor

PROJECT SUMMARY/ABSTRACT This proposal is focused on establishing the efficacy of protective coatings in minimizing surface degradation of glass-ceramic veneers as well as minimizing chipping of ceramic-ceramic prostheses. This R01 proposal is designed to analyze the chemical durability and fracture resistance of three glass-ceramic veneering materials with different microstructures through in vitro simulation tests and to determine whether a novel pH cycling methodology will reliably simulate the chemical degradation that is controlled by pH fluctuations in the oral environment. The long-term goal of this research program is to develop fracture-resistant and chemically stable (durable), dental ceramic coatings for veneered dental ceramic prostheses. The central hypothesis of this project is that dental ceramic veneers will sustain minimal surface degradation and maintain or increase their apparent strength when coated with an optimized protective, adherent surface layer. This unique, translational research project will apply corrosion testing and damage analysis of ceramic veneering materials through in vitro simulation. We will employ a novel pH cycling methodology, which will apply three sequences of alternating pH buffer solutions from acidic to alkali, alongside intermittent abrasion. This cycling mechanism effectively simulates the fluctuating pH levels of oral fluids and can more accurately test chemical durability of ceramic materials. More importantly, we will establish the effectiveness of optimized protective coatings deposited using plasma enhanced coating vapor deposition technology in minimizing ceramic corrosion and improving fracture resistance. We will analyze the surface composition and topographical changes using x-ray photoelectron spectroscopy (XPS), environmental scanning electron microscopy (ESEM), energy dispersive x-ray analysis (EDAX), digital microscopy, and 3D laserscanning for wear analysis. We propose the following aims to test our central hypothesis: Aim 1: Test the hypothesis that glass-ceramic veneers undergo an alternating dissolution process (selective leaching and total dissolution) as a function of cycling pH environments resulting in compositional changes and rapid surface degradation of the glass phase; Aim 2: Test the hypothesis that a significant decrease in the biaxial flexural strength of glass- ceramic veneers will occur as a result of a simulated oral environment of alternating low and high pH or simulated occlusal forces with intermittent abrasion or a combination of both; Aim 3: Test the hypothesis that a protective coating can be optimized to achieve good resistance to low pH and high pH environments, ideal bonding to the ceramic substrate, good abrasion and fracture resistance and proper esthetics; Aim 4: Test the hypothesis that the optimal protective coating will significantly decrease the in vitro corrosive rate of glass- ceramic veneers as evidenced by a reduction in surface compositional changes caused by fluctuations in pH and abrasion factors, and maintain or significantly increase their “apparent” biaxial flexural strength.

项目概要/摘要 该提案的重点是确定保护涂层在最大限度地减少表面退化方面的功效 玻璃陶瓷贴面以及最大限度地减少陶瓷陶瓷假体的碎裂。这个R01提案是 旨在分析三种微晶玻璃贴面材料的化学耐久性和抗断裂性 通过体外模拟测试具有不同的微观结构并确定是否具有新颖的pH循环 该方法将可靠地模拟由口腔中 pH 值波动控制的化学降解 环境。该研究计划的长期目标是开发抗断裂且化学稳定的材料 （耐用），用于贴面牙科陶瓷修复体的牙科陶瓷涂层。这个假设的中心假设 项目的目标是牙科陶瓷贴面将维持最小的表面退化并保持或增加其 涂有优化的保护性粘附表面层时的表观强度。 这个独特的转化研究项目将应用陶瓷的腐蚀测试和损伤分析 通过体外模拟饰面材料。我们将采用一种新颖的 pH 循环方法，该方法将 使用三个顺序交替的 pH 缓冲溶液（从酸性到碱性），同时进行间歇性磨损。 这种循环机制有效模拟了口腔液pH值的波动，可以更准确地 测试陶瓷材料的化学耐久性。更重要的是，我们将建立优化的有效性 使用等离子增强涂层气相沉积技术沉积的保护涂层，最大限度地减少 陶瓷腐蚀和提高抗断裂性能。我们将分析表面成分并 使用 X 射线光电子能谱 (XPS)、环境扫描电子分析地形变化 显微镜 (ESEM)、能量色散 X 射线分析 (EDAX)、数字显微镜和 3D 激光扫描 磨损分析。我们提出以下目标来检验我们的中心假设： 目标 1：检验假设 微晶玻璃贴面经历交替溶解过程（选择性浸出和完全溶解） pH 环境循环导致成分变化和表面快速降解的函数 玻璃相；目标 2：检验玻璃的双轴弯曲强度显着降低的假设 陶瓷贴面的形成是由于模拟口腔环境的低和高 pH 值交替变化或 模拟咬合力与间歇性磨损或两者的组合；目标 3：检验假设 保护涂层可经过优化，实现对低 pH 值和高 pH 环境的良好抵抗力，理想的 与陶瓷基材的结合力好，耐磨、抗断裂性好，美观；目标 4：测试 假设最佳的保护涂层将显着降低玻璃的体外腐蚀速率 pH值波动引起的表面成分变化减少证明了陶瓷贴面 和磨损因素，并保持或显着提高其“表观”双轴弯曲强度。