Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions

现实生活中社交互动中社交脑功能障碍的猕猴模型

• 批准号: 9309071
• 负责人: Steve Wohn Chul Chang
• 金额: $ 52.93万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9309071
• 关键词: Affect; Amygdaloid structure; Animal Model; Area; Attention; Autistic Disorder; Behavior; Behavioral; Brain region; Code; Communication; Complex; Coupling; Decision Making; Electric Stimulation; Event; Eye; Face; Frequencies; Functional disorder; Future; Goals; Image; Impairment; Individual; Intervention; Knowledge; Life; Link; Macaca; Macaca mulatta; Major Depressive Disorder; Measures; Medial; Mediating; Mental disorders; Modeling; Monitor; Monkeys; Neurons; Pattern; Pharmaceutical Preparations; Pharmacology; Population; Primates; Procedures; Rewards; Safety; Social Behavior; Social Interaction; Structure; Testing; Time; Treatment Efficacy; Update; base; brain dysfunction; cognitive process; directed attention; frontal lobe; gaze; microstimulation; movie; neurobiological mechanism; neuroimaging; neuromechanism; nonhuman primate; novel; preference; psychopathic personality; public health relevance; relating to nervous system; response; social; social anxiety; social attention; social cognition; social integration

Project Summary Our proposal will investigate how neuronal coordination between the medial frontal cortex (MFC) and the basolateral amygdala (BLA) is causally involved in complex social interactions. We will capitalize on our newly developed social gaze interaction paradigm in pairs of rhesus macaques to understand the neurobiological mechanisms of MFC-BLA coupling, with a goal of working toward generating a macaque model of social dysfunction. We will first determine whether and how the two regions are coordinated during various social gaze events (e.g., looking at the eyes or mutual eye contact). We will then stimulate MFC, BLA or both in order to disrupt the MFC-BLA coordination to induce social gaze deficits. Finally, we will examine whether these disruptions are generalizable to other social domains by testing the impact of perturbing MFC-BLA coordination in a complex social decision-making game. Informed by these results, we hope to investigate in the future how pharmacological (systemic or focal drug manipulations) and behavioral (social interaction manipulations) interventions could effectively restore the inducible social deficits.

项目总结