Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions

现实生活中社交互动中社交脑功能障碍的猕猴模型

基本信息

  • 批准号:
    9309071
  • 负责人:
  • 金额:
    $ 52.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-07-01 至 2021-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary Our proposal will investigate how neuronal coordination between the medial frontal cortex (MFC) and the basolateral amygdala (BLA) is causally involved in complex social interactions. We will capitalize on our newly developed social gaze interaction paradigm in pairs of rhesus macaques to understand the neurobiological mechanisms of MFC-BLA coupling, with a goal of working toward generating a macaque model of social dysfunction. We will first determine whether and how the two regions are coordinated during various social gaze events (e.g., looking at the eyes or mutual eye contact). We will then stimulate MFC, BLA or both in order to disrupt the MFC-BLA coordination to induce social gaze deficits. Finally, we will examine whether these disruptions are generalizable to other social domains by testing the impact of perturbing MFC-BLA coordination in a complex social decision-making game. Informed by these results, we hope to investigate in the future how pharmacological (systemic or focal drug manipulations) and behavioral (social interaction manipulations) interventions could effectively restore the inducible social deficits.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Steve Wohn Chul Chang其他文献

Steve Wohn Chul Chang的其他文献

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{{ truncateString('Steve Wohn Chul Chang', 18)}}的其他基金

Neural investigations into cooperative social interactions in marmoset dyads
狨猴二人组合作社会互动的神经研究
  • 批准号:
    10369856
  • 财政年份:
    2022
  • 资助金额:
    $ 52.93万
  • 项目类别:
Neural investigations into cooperative social interactions in marmoset dyads
狨猴二人组合作社会互动的神经研究
  • 批准号:
    10551217
  • 财政年份:
    2022
  • 资助金额:
    $ 52.93万
  • 项目类别:
Prefrontal and Amygdalar Mechanisms of Live Social Gaze Interaction
实时社交凝视互动的前额叶和杏仁核机制
  • 批准号:
    10670053
  • 财政年份:
    2022
  • 资助金额:
    $ 52.93万
  • 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
  • 批准号:
    10406985
  • 财政年份:
    2019
  • 资助金额:
    $ 52.93万
  • 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
  • 批准号:
    10630140
  • 财政年份:
    2019
  • 资助金额:
    $ 52.93万
  • 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
  • 批准号:
    10176600
  • 财政年份:
    2019
  • 资助金额:
    $ 52.93万
  • 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
  • 批准号:
    9796897
  • 财政年份:
    2019
  • 资助金额:
    $ 52.93万
  • 项目类别:
Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions
现实生活中社交互动中社交脑功能障碍的猕猴模型
  • 批准号:
    9900591
  • 财政年份:
    2016
  • 资助金额:
    $ 52.93万
  • 项目类别:
Role of Oxytocin in the Amygdala-Prefrontal Network During Social Decision-Making
催产素在社会决策过程中杏仁核前额叶网络中的作用
  • 批准号:
    8878644
  • 财政年份:
    2014
  • 资助金额:
    $ 52.93万
  • 项目类别:
Role of Oxytocin in the Amygdala-Prefrontal Network During Social Decision-Making
催产素在社会决策过程中杏仁核前额叶网络中的作用
  • 批准号:
    8894608
  • 财政年份:
    2014
  • 资助金额:
    $ 52.93万
  • 项目类别:
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