Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions

现实生活中社交互动中社交脑功能障碍的猕猴模型

• 批准号: 9309071
• 负责人: Steve Wohn Chul Chang
• 金额: $ 52.93万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9309071
• 关键词: Affect; Amygdaloid structure; Animal Model; Area; Attention; Autistic Disorder; Behavior; Behavioral; Brain region; Code; Communication; Complex; Coupling; Decision Making; Electric Stimulation; Event; Eye; Face; Frequencies; Functional disorder; Future; Goals; Image; Impairment; Individual; Intervention; Knowledge; Life; Link; Macaca; Macaca mulatta; Major Depressive Disorder; Measures; Medial; Mediating; Mental disorders; Modeling; Monitor; Monkeys; Neurons; Pattern; Pharmaceutical Preparations; Pharmacology; Population; Primates; Procedures; Rewards; Safety; Social Behavior; Social Interaction; Structure; Testing; Time; Treatment Efficacy; Update; base; brain dysfunction; cognitive process; directed attention; frontal lobe; gaze; microstimulation; movie; neurobiological mechanism; neuroimaging; neuromechanism; nonhuman primate; novel; preference; psychopathic personality; public health relevance; relating to nervous system; response; social; social anxiety; social attention; social cognition; social integration

Project Summary Our proposal will investigate how neuronal coordination between the medial frontal cortex (MFC) and the basolateral amygdala (BLA) is causally involved in complex social interactions. We will capitalize on our newly developed social gaze interaction paradigm in pairs of rhesus macaques to understand the neurobiological mechanisms of MFC-BLA coupling, with a goal of working toward generating a macaque model of social dysfunction. We will first determine whether and how the two regions are coordinated during various social gaze events (e.g., looking at the eyes or mutual eye contact). We will then stimulate MFC, BLA or both in order to disrupt the MFC-BLA coordination to induce social gaze deficits. Finally, we will examine whether these disruptions are generalizable to other social domains by testing the impact of perturbing MFC-BLA coordination in a complex social decision-making game. Informed by these results, we hope to investigate in the future how pharmacological (systemic or focal drug manipulations) and behavioral (social interaction manipulations) interventions could effectively restore the inducible social deficits.

项目概要 我们的提案将研究内侧额叶皮层（MFC）和大脑皮层之间的神经元协调如何 基底外侧杏仁核（BLA）因果性地参与复杂的社会互动。我们将利用我们的新 在一对恒河猴中开发了社交凝视互动范式，以了解神经生物学 MFC-BLA 耦合机制，目标是生成猕猴社交模型 功能障碍。我们首先要确定两个地区在各种社会活动中是否以及如何协调。 凝视事件（例如，注视眼睛或相互目光接触）。然后我们将按顺序刺激 MFC、BLA 或两者 破坏 MFC-BLA 协调，导致社交凝视缺陷。最后，我们将检查这些是否 通过测试扰动 MFC-BLA 协调的影响，破坏可以推广到其他社会领域 在复杂的社会决策博弈中。根据这些结果，我们希望在未来研究如何 药理学（全身或局部药物操作）和行为（社交互动操作） 干预措施可以有效恢复诱发的社会赤字。