Neural investigations into cooperative social interactions in marmoset dyads
狨猴二人组合作社会互动的神经研究
基本信息
- 批准号:10551217
- 负责人:
- 金额:$ 20.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AltruismAnimalsAttenuatedBehaviorBehavioralBehavioral ParadigmBiological ModelsBrainBrain regionBreedingCallithrixCallithrix jacchus jacchusCatalogsCharacteristicsCodeComplexCooperative BehaviorDataDependenceElectrodesElectrophysiology (science)ElementsEthologyExhibitsFaceFunctional Magnetic Resonance ImagingFutureHeadHumanIndividualInvestigationLaboratory Animal ModelsMaintenanceMediatingNeurobiologyNeuronsNeurophysiology - biologic functionNeurosciencesOutcomePlayPrefrontal CortexPrimatesProbabilityProcessPropertyRecording of previous eventsResearchResolutionRewardsRoleSexual PartnersShapesSignal TransductionSocial BehaviorSocial FunctioningSocial InteractionTimeTransgenic Organismsbasebehavior predictionbehavioral studydeep learningdensityexperimental studyfield studyimaging studyinnovationinterestlearning networkmemberneuralneuroimagingneuromechanismneurotransmissionnonhuman primatenovel strategiesprogramspublic health relevancerestraintsexsocialsocial cognitionsocial cooperationsocial deficitssocial factorssocial groupsocial structurewireless
项目摘要
Project Summary
Advanced social cognition permits cooperative and reciprocal interactions with other group members, making it
possible for us and other highly social animals to capitalize on various benefits associated with prosociality.
However, investigating the neural bases of cooperative interactions is quite challenging largely due to the fact
that standard laboratory animal models of neuroscience do not overtly or reliably exhibit cooperative behaviors,
let alone reciprocity based on altruism. Marmosets are cooperatively breeding non-human primates known for
their prosociality and socially tolerant characteristics making them a model system with strong potential for use
towards understanding complex social behaviors. Marmosets also provide strong promise for generating
transgenic primates, and their flat cortices allow easy access to brain regions with high-density electrodes. In
this exploratory R21 proposal, we will capitalize on recent advances in video-based continuous tracking of facial
features and body orientations using a deep learning network to rigorously characterize cooperative interactions
of marmoset dyads. Further, we will study neural activity from the orbitofrontal cortex (OFC) and the dorsolateral
prefrontal cortex (dlPFC) – the two prefrontal regions centrally implicated in cooperation based on human
functional magnetic resonance imaging studies – using wireless and high-density neural recording, allowing
examinations of neural activity during naturalistic social interactions that are not accessible in traditional head-
restrained electrophysiology experiments. We will apply these novel approaches in a cooperative behavioral
paradigm inspired by marmoset behavioral ethology and primatology. We hypothesize that neurons in the OFC
process reinforcing properties of cooperation, whereas neurons in the dlPFC strategically implement cooperation
decisions. Overall, our proposal uniquely allows studying neural dynamics with precise, naturalistic, behavioral
data, overcoming the difficulty of using naturalistic behaviors in experimental settings and of collecting neural
data in observational field studies. The data from this R21 proposal will be critical for developing a larger research
program in the future with multiple scopes and causal elements for understanding the neural mechanisms
underlying cooperative social interaction.
项目总结
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Steve Wohn Chul Chang其他文献
Steve Wohn Chul Chang的其他文献
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{{ truncateString('Steve Wohn Chul Chang', 18)}}的其他基金
Neural investigations into cooperative social interactions in marmoset dyads
狨猴二人组合作社会互动的神经研究
- 批准号:
10369856 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Prefrontal and Amygdalar Mechanisms of Live Social Gaze Interaction
实时社交凝视互动的前额叶和杏仁核机制
- 批准号:
10670053 - 财政年份:2022
- 资助金额:
$ 20.94万 - 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
- 批准号:
10406985 - 财政年份:2019
- 资助金额:
$ 20.94万 - 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
- 批准号:
10630140 - 财政年份:2019
- 资助金额:
$ 20.94万 - 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
- 批准号:
10176600 - 财政年份:2019
- 资助金额:
$ 20.94万 - 项目类别:
Behavioral and Neural Bases of Combining Oxytocin and Naloxone for Optimally Enhancing Interactive Social Attention
结合催产素和纳洛酮优化增强互动社交注意力的行为和神经基础
- 批准号:
9796897 - 财政年份:2019
- 资助金额:
$ 20.94万 - 项目类别:
Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions
现实生活中社交互动中社交脑功能障碍的猕猴模型
- 批准号:
9900591 - 财政年份:2016
- 资助金额:
$ 20.94万 - 项目类别:
Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions
现实生活中社交互动中社交脑功能障碍的猕猴模型
- 批准号:
9309071 - 财政年份:2016
- 资助金额:
$ 20.94万 - 项目类别:
Role of Oxytocin in the Amygdala-Prefrontal Network During Social Decision-Making
催产素在社会决策过程中杏仁核前额叶网络中的作用
- 批准号:
8878644 - 财政年份:2014
- 资助金额:
$ 20.94万 - 项目类别:
Role of Oxytocin in the Amygdala-Prefrontal Network During Social Decision-Making
催产素在社会决策过程中杏仁核前额叶网络中的作用
- 批准号:
8894608 - 财政年份:2014
- 资助金额:
$ 20.94万 - 项目类别:
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