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Neural investigations into cooperative social interactions in marmoset dyads

狨猴二人组合作社会互动的神经研究

基本信息

批准号：
10551217
负责人：
Steve Wohn Chul Chang
金额：
$ 20.94万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10551217
关键词：
Altruism Animals Attenuated Behavior Behavioral Behavioral Paradigm Biological Models Brain Brain region Breeding Callithrix Callithrix jacchus jacchus Catalogs Characteristics Code Complex Cooperative Behavior Data Dependence Electrodes Electrophysiology (science)Elements Ethology Exhibits Face Functional Magnetic Resonance Imaging Future Head Human Individual Investigation Laboratory Animal Models Maintenance Mediating Neurobiology Neurons Neurophysiology - biologic function Neurosciences Outcome Play Prefrontal Cortex Primates Probability Process Property Recording of previous events Research Resolution Rewards Role Sexual Partners Shapes Signal Transduction Social Behavior Social Functioning Social Interaction Time Transgenic Organisms base behavior prediction behavioral study deep learning density experimental study field study imaging study innovation interest learning network member neural neuroimaging neuromechanism neurotransmission nonhuman primate novel strategies programs public health relevance restraint sex social social cognition social cooperation social deficits social factors social group social structure wireless

项目摘要

Project Summary Advanced social cognition permits cooperative and reciprocal interactions with other group members, making it possible for us and other highly social animals to capitalize on various benefits associated with prosociality. However, investigating the neural bases of cooperative interactions is quite challenging largely due to the fact that standard laboratory animal models of neuroscience do not overtly or reliably exhibit cooperative behaviors, let alone reciprocity based on altruism. Marmosets are cooperatively breeding non-human primates known for their prosociality and socially tolerant characteristics making them a model system with strong potential for use towards understanding complex social behaviors. Marmosets also provide strong promise for generating transgenic primates, and their flat cortices allow easy access to brain regions with high-density electrodes. In this exploratory R21 proposal, we will capitalize on recent advances in video-based continuous tracking of facial features and body orientations using a deep learning network to rigorously characterize cooperative interactions of marmoset dyads. Further, we will study neural activity from the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (dlPFC) – the two prefrontal regions centrally implicated in cooperation based on human functional magnetic resonance imaging studies – using wireless and high-density neural recording, allowing examinations of neural activity during naturalistic social interactions that are not accessible in traditional head- restrained electrophysiology experiments. We will apply these novel approaches in a cooperative behavioral paradigm inspired by marmoset behavioral ethology and primatology. We hypothesize that neurons in the OFC process reinforcing properties of cooperation, whereas neurons in the dlPFC strategically implement cooperation decisions. Overall, our proposal uniquely allows studying neural dynamics with precise, naturalistic, behavioral data, overcoming the difficulty of using naturalistic behaviors in experimental settings and of collecting neural data in observational field studies. The data from this R21 proposal will be critical for developing a larger research program in the future with multiple scopes and causal elements for understanding the neural mechanisms underlying cooperative social interaction.

项目总结