Neural investigations into cooperative social interactions in marmoset dyads

狨猴二人组合作社会互动的神经研究

• 批准号: 10551217
• 负责人: Steve Wohn Chul Chang
• 金额: $ 20.94万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551217
• 关键词: Altruism; Animals; Attenuated; Behavior; Behavioral; Behavioral Paradigm; Biological Models; Brain; Brain region; Breeding; Callithrix; Callithrix jacchus jacchus; Catalogs; Characteristics; Code; Complex; Cooperative Behavior; Data; Dependence; Electrodes; Electrophysiology (science); Elements; Ethology; Exhibits; Face; Functional Magnetic Resonance Imaging; Future; Head; Human; Individual; Investigation; Laboratory Animal Models; Maintenance; Mediating; Neurobiology; Neurons; Neurophysiology - biologic function; Neurosciences; Outcome; Play; Prefrontal Cortex; Primates; Probability; Process; Property; Recording of previous events; Research; Resolution; Rewards; Role; Sexual Partners; Shapes; Signal Transduction; Social Behavior; Social Functioning; Social Interaction; Time; Transgenic Organisms; base; behavior prediction; behavioral study; deep learning; density; experimental study; field study; imaging study; innovation; interest; learning network; member; neural; neuroimaging; neuromechanism; neurotransmission; nonhuman primate; novel strategies; programs; public health relevance; restraint; sex; social; social cognition; social cooperation; social deficits; social factors; social group; social structure; wireless

Project Summary Advanced social cognition permits cooperative and reciprocal interactions with other group members, making it possible for us and other highly social animals to capitalize on various benefits associated with prosociality. However, investigating the neural bases of cooperative interactions is quite challenging largely due to the fact that standard laboratory animal models of neuroscience do not overtly or reliably exhibit cooperative behaviors, let alone reciprocity based on altruism. Marmosets are cooperatively breeding non-human primates known for their prosociality and socially tolerant characteristics making them a model system with strong potential for use towards understanding complex social behaviors. Marmosets also provide strong promise for generating transgenic primates, and their flat cortices allow easy access to brain regions with high-density electrodes. In this exploratory R21 proposal, we will capitalize on recent advances in video-based continuous tracking of facial features and body orientations using a deep learning network to rigorously characterize cooperative interactions of marmoset dyads. Further, we will study neural activity from the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (dlPFC) – the two prefrontal regions centrally implicated in cooperation based on human functional magnetic resonance imaging studies – using wireless and high-density neural recording, allowing examinations of neural activity during naturalistic social interactions that are not accessible in traditional head- restrained electrophysiology experiments. We will apply these novel approaches in a cooperative behavioral paradigm inspired by marmoset behavioral ethology and primatology. We hypothesize that neurons in the OFC process reinforcing properties of cooperation, whereas neurons in the dlPFC strategically implement cooperation decisions. Overall, our proposal uniquely allows studying neural dynamics with precise, naturalistic, behavioral data, overcoming the difficulty of using naturalistic behaviors in experimental settings and of collecting neural data in observational field studies. The data from this R21 proposal will be critical for developing a larger research program in the future with multiple scopes and causal elements for understanding the neural mechanisms underlying cooperative social interaction.

项目概要 先进的社会认知允许与其他群体成员进行合作和互惠互动，从而使其 我们和其他高度社会化的动物有可能利用与亲社会性相关的各种好处。 然而，研究协作交互的神经基础相当具有挑战性，很大程度上是因为以下事实 神经科学的标准实验动物模型不会公开或可靠地表现出合作行为， 更不用说基于利他主义的互惠了。狨猴是合作繁殖的非人类灵长类动物，以 它们的亲社会性和社会宽容特征使它们成为具有强大使用潜力的模型系统 理解复杂的社会行为。狨猴也为发电提供了强有力的承诺 转基因灵长类动物的扁平皮质使得高密度电极能够轻松进入大脑区域。在 在这个探索性的 R21 提案中，我们将利用基于视频的面部连续跟踪的最新进展 使用深度学习网络来严格表征协作交互的特征和身体方向 狨猴二人组。此外，我们将研究眶额皮层 (OFC) 和背外侧皮层的神经活动 前额叶皮层 (dlPFC) – 两个前额叶区域主要涉及基于人类的合作 功能磁共振成像研究——使用无线和高密度神经记录，允许 对自然社会互动过程中的神经活动进行检查，这是传统头脑中无法访问的 限制性电生理学实验。我们将在合作行为中应用这些新颖的方法 范式受到狨猴行为行为学和灵长类动物学的启发。我们假设 OFC 中的神经元 过程强化合作的特性，而 dlPFC 中的神经元战略性地实施合作 决定。总的来说，我们的建议独特地允许以精确、自然、行为的方式研究神经动力学 数据，克服了在实验环境中使用自然行为和收集神经元的困难 实地观察研究中的数据。 R21 提案中的数据对于开展更大规模的研究至关重要 未来的计划具有多个范围和因果元素，用于理解神经机制 潜在的合作性社会互动。