Prefrontal and Amygdalar Mechanisms of Live Social Gaze Interaction

实时社交凝视互动的前额叶和杏仁核机制

• 批准号: 10670053
• 负责人: Steve Wohn Chul Chang
• 金额: $ 57.05万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670053
• 关键词: Agonist; Amygdaloid structure; Area; Attention; Behavior; Behavioral; Brain; Brain region; Code; Communication; Complex; Cues; Data; Eye; Familiarity; Human; Individual; Juice; Lead; Life; Link; Macaca; Modeling; Neurons; Pattern; Personal Communication; Process; Rewards; Role; Shapes; Signal Transduction; Social Behavior; Social Environment; Social Interaction; Stimulus; Sum; Testing; directed attention; gaze; information processing; neural; neural circuit; neural correlate; neurotransmission; nonhuman primate; preference; receptor; social; social cognition; social deficits; stimulus processing

Project Summary Social interactions are marked by contingent and dynamic gaze exchanges among individuals, and these exchanges powerfully shape inter-individual communication and coordinated social behaviors. Consequentially, divergent social gaze interactions frequently lead to challenges in gathering and processing information from others and further disrupt other social cognition. An excellent use of a non-human primate model is to study neural circuits underlying contingent and dynamic social gaze, and test for their causal contributions. We have shown that interacting with a real partner leads to drastically different social gaze dynamics compared to observing the same conspecific in pictures or videos. Furthermore, using this live social gaze interaction paradigm, we have recently found robust neural correlates of social gaze interaction in the orbitofrontal cortex (OFC) and the basolateral amygdala (BLA). However, causal roles of OFC and BLA, and the OFC-BLA interplay, in regulating social gaze interaction remain unestablished. Informed by our latest data and other emerging findings from the field, we hypothesize that (1) BLA is required for preferentially directing attention to social stimuli by processing social gaze valence, whereas (2) OFC is required for regulating social gaze interaction according to social context, and that (3) the communication between OFC and BLA is required for contingent and dynamic social gaze interaction. To test this overarching hypothesis, we will first examine the functional relationship between social gaze preference and value processing in OFC and BLA neurons. We hypothesize that BLA neurons process social gaze interaction using a valence schema, whereas OFC neurons do not. Second, we will examine the necessity of OFC, BLA, and the OFC-BLA interplay in social gaze interaction by temporarily inactivating OFC or BLA, or cross-inactivating OFC and BLA. We hypothesize that BLA is necessary for preferentially directing attention to partner’s eyes and processing them, whereas OFC is necessary for social context-dependent changes in gaze dynamics linked to dominance and familiarity between pairs. We also predict that the direct communication between OFC and BLA is particularly crucial for interactive aspects of social gaze. Finally, by recording neural activity from one area while temporarily inactivating the other area, we will examine the neural representations of social gaze interaction in OFC and BLA that require functioning BLA or OFC, respectively. Results from this proposal will provide functionally informed causal contributions of the OFC-BLA circuits in real-life social gaze interaction.

项目摘要 社会互动的特点是个人之间的偶然和动态的目光交换，这些 交流有力地塑造了个体间的沟通和协调的社会行为。因此， 不同的社交凝视互动经常导致收集和处理信息的挑战 其他人，并进一步扰乱其他社会认知。非人类灵长类动物模型的一个很好的用途是研究 潜在的偶然性和动态社会凝视的神经回路，并测试其因果关系的贡献。我们有 显示与真实的伴侣互动会导致截然不同的社会注视动态， 在图片或视频中观察相同的同种。此外，使用这种实时的社会凝视互动， 范例，我们最近发现了强大的神经相关的社会凝视互动的眶额皮层 (OFC)和基底外侧杏仁核（BLA）。然而，OFC和BLA的因果作用，以及OFC-BLA的相互作用， 在调节社会注视互动方面的作用仍然没有建立。根据我们的最新数据和其他新兴数据， 从该领域的研究结果，我们假设（1）BLA是需要优先将注意力转向社会 社会注视效价的加工刺激，而（2）OFC是调节社会注视互动所必需的 根据社会背景，（3）OFC和BLA之间的沟通是必要的， 和动态的社会凝视互动。为了检验这个总体假设，我们将首先检查函数 OFC和BLA神经元的社会注视偏好与价值加工的关系我们假设 BLA神经元使用效价模式处理社交凝视互动，而OFC神经元则不然。 其次，我们将通过以下方式来检验OFC、BLA以及OFC-BLA相互作用在社会凝视互动中的必要性： 暂时灭活OFC或BLA，或交叉灭活OFC和BLA。我们假设BLA是必要的 优先将注意力引导到伴侣的眼睛并处理它们，而OFC是社交所必需的。 背景依赖的变化，在凝视动力学与优势和熟悉对之间。我们还预计 OFC和BLA之间的直接沟通对于社交凝视的互动方面尤为重要。 最后，通过记录一个区域的神经活动，同时暂时关闭另一个区域，我们将检查 OFC和BLA中需要功能性BLA或OFC的社会凝视交互的神经表征， 分别本提案的结果将提供OFC-BLA的功能性因果贡献 在现实生活中的社会凝视互动电路。