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Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions

现实生活中社交互动中社交脑功能障碍的猕猴模型

基本信息

批准号：
9900591
负责人：
Steve Wohn Chul Chang
金额：
$ 46.32万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9900591
关键词：
Affect Amygdaloid structure Animal Model Area Attention Behavior Behavioral Brain region Code Communication Complex Coupling Decision Making Electric Stimulation Event Eye Face Frequencies Future Goals Image Impairment Individual Intervention Knowledge Life Link Macaca Macaca mulatta Major Depressive Disorder Measures Medial Mediating Mental disorders Modeling Monitor Monkeys Neurons Pattern Pharmaceutical Preparations Pharmacology Population Primates Procedures Rewards Safety Social Behavior Social Interaction Structure Testing Time Treatment Efficacy Update autism spectrum disorder base brain dysfunction cognitive process directed attention frontal lobe gaze microstimulation movie neurobiological mechanism neuroimaging neuromechanism nonhuman primate novel preference psychopathic personality public health relevance relating to nervous system response social social anxiety social attention social cognition social deficits social integration

项目摘要

Project Summary Our proposal will investigate how neuronal coordination between the medial frontal cortex (MFC) and the basolateral amygdala (BLA) is causally involved in complex social interactions. We will capitalize on our newly developed social gaze interaction paradigm in pairs of rhesus macaques to understand the neurobiological mechanisms of MFC-BLA coupling, with a goal of working toward generating a macaque model of social dysfunction. We will first determine whether and how the two regions are coordinated during various social gaze events (e.g., looking at the eyes or mutual eye contact). We will then stimulate MFC, BLA or both in order to disrupt the MFC-BLA coordination to induce social gaze deficits. Finally, we will examine whether these disruptions are generalizable to other social domains by testing the impact of perturbing MFC-BLA coordination in a complex social decision-making game. Informed by these results, we hope to investigate in the future how pharmacological (systemic or focal drug manipulations) and behavioral (social interaction manipulations) interventions could effectively restore the inducible social deficits.

项目摘要我们的建议将调查内侧额叶皮层（MFC）和大脑皮层之间的神经元协调是如何进行的。基底外侧杏仁核（BLA）与复杂的社会互动有因果关系。我们将利用我们新的在成对的恒河猴中开发了社会凝视互动范式，以了解神经生物学 MFC-BLA偶联的机制，目标是产生一个猕猴模型的社会功能障碍我们将首先确定两个地区在各种社会活动中是否协调以及如何协调。注视事件（例如，看对方的眼睛或眼神交流）。然后，我们将刺激MFC，BLA或两者，破坏MFC-BLA协调以诱导社交注视缺陷。最后，我们将研究这些通过测试扰乱MFC-BLA协调的影响，可以将干扰推广到其他社会领域在一个复杂的社会决策游戏中。根据这些结果，我们希望在未来研究如何药理学（全身性或局灶性药物操作）和行为学（社会互动操作）干预措施可以有效地恢复诱发的社会赤字。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Levels of naturalism in social neuroscience research.

DOI：
10.1016/j.isci.2021.102702
发表时间：
2021-07-23
期刊：
iScience
影响因子：
5.8
作者：
Fan S;Dal Monte O;Chang SWC
通讯作者：
Chang SWC

Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks.

DOI：
10.1016/j.neuron.2022.04.013
发表时间：
2022-07-06
期刊：
NEURON
影响因子：
16.2
作者：
Dal Monte, Olga;Fan, Siqi;Fagan, Nicholas A.;Chu, Cheng-Chi J.;Zhou, Michael B.;Putnam, Philip T.;Nair, Amrita R.;Chang, Steve W. C.
通讯作者：
Chang, Steve W. C.

Amygdala connectivity and implications for social cognition and disorders.