Health Effects and Geochemistry of Arsenic

砷的健康影响和地球化学

基本信息

  • 批准号:
    9257600
  • 负责人:
  • 金额:
    $ 141.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-06-01 至 2020-03-31
  • 项目状态:
    已结题

项目摘要

Overall - Project Summary/Abstract: The contamination of water and aquifer sediments with arsenic (As) is associated with major public health and environmental mitigation issues in the United States. At present, 823 of 1739 U.S. Superfund sites list As as a major contaminant; in addition millions of U.S. residents are unduly exposed due to naturally occurring As in their household well water. This proposal includes two biomedical and two geoscience projects that seek to address critically important issues that collectively aim to reduce As exposure and toxicity in exposed human populations in the U.S. and in Bangladesh, where much information can be learned that will benefit residents of the U.S. and elsewhere. The proposal builds on the strengths of our existing longitudinal cohort study of 35,000 adults in Bangladesh by examining dose-response relationships between As exposure (in the low-mid range) from contaminated food and water with incident cases (and sub-types) of cardiovascular disease (CVD) and non-malignant lung disease, as well as diabetes mellitus (DM). In addition, we will combine and meta-analyze data from Bangladesh, Taiwan, China (Inner Mongolia) and the U.S. (AZ, CO, ND, OK, SD) to refine the dose-response relationships between As exposure and CVD. We build off our previous observations that: a) As exposure is associated with deficits in child intelligence; and b) that folate, a B vitamin, facilitates As metabolism and elimination in adults. We propose to conduct a randomized clinical trial in 8-10 year old children in Bangladesh to test the hypothesis that folate+B12 supplementation can: a) lower blood As; and b) improve cognitive abilities in children. Building on our previous geoscience research which indicates that in situ magnetite formation forms a diffuse barrier capable of long-term As retention, we propose to conduct laboratory and field research to optimize and implement this new approach at a U.S. Geological Survey research site on Cape Cod, MA and a Superfund site in Raleigh, NC. In Bangladesh, we will quantify the geographic and socio-political barriers to reducing As exposure by analyzing the vast data sets accumulated in our main study area and we will conduct a randomized controlled trial comparing ways to overcome some of them. In parallel, we will continue to examine the potential vulnerability to human perturbations of shallow and deep aquifers that are low in As. These low As aquifers are crucial for reducing exposure to our study population and the country at large. In the U.S., we will build on our proven success of partnering with state and local governments to reduce As exposure in communities that rely on As-contaminated household wells in ME, NJ and MN. We will also continue to facilitate effective communication among our SRP scientists, stakeholders and government partners via five specific strategies. Finally, we will continue to train the next generation of scientists with disciplinary and inter-disciplinary skills that will enable them to improve the health of those who reside in environments that might expose them to As and other contaminants in soil, water and food.
总体--项目摘要/摘要:水和含水层沉积物受砷污染的情况如下 与美国的重大公共卫生和环境缓解问题有关。目前,823人 1739个美国超级基金网站被列为主要污染物;此外,数百万美国居民不适当地 由于自然暴露在自家井水中。这项提案包括两个生物医学 和两个寻求解决极端重要问题的地球科学项目,这些问题共同旨在减少 在美国和孟加拉国,暴露在人群中的暴露和毒性,那里有很多信息 可以了解到,这将使美国和其他地方的居民受益。这项建议建立在以下优势的基础上 我们现有的对孟加拉国35,000名成年人的纵向队列研究通过检查剂量反应 受污染食物和水中砷暴露(中低范围)与事故的关系 心血管疾病(心血管疾病)和非恶性肺部疾病以及糖尿病的病例(和亚型) 糖尿病(DM)。此外,我们将结合和荟萃分析来自孟加拉国、台湾、中国(内省)的数据 蒙古)和美国(AZ、CO、ND、OK、SD),以完善砷暴露之间的剂量-反应关系 和心血管疾病。我们建立在我们之前的观察基础上:a)因为暴露与儿童的缺陷有关 智力;和b)叶酸,一种B族维生素,有助于成年人的新陈代谢和消除。我们建议 在孟加拉国8-10岁儿童中进行一项随机临床试验,以检验叶酸+B12的假设 补充可以:a)降低血液中的AS;b)提高儿童的认知能力。 基于我们之前的地学研究,表明原地磁铁矿形成了一个 能够长期滞留的漫反射屏障,我们建议进行实验室和现场研究 在马萨诸塞州科德角的美国地质调查局研究地点优化和实施这一新方法 位于北卡罗来纳州罗利市的超级基金网站。在孟加拉国,我们将量化地理和社会政治障碍 通过分析我们主要研究领域积累的大量数据集来减少AS风险,我们将进行 一项随机对照试验,比较了克服其中一些问题的方法。与此同时,我们将继续 研究砷含量较低的浅层和深层含水层对人类干扰的潜在脆弱性。 这些较低的含水层对于减少对我们的研究人群和整个国家的暴露至关重要。 在美国,我们将以我们与州和地方政府合作取得的成功为基础, 减少梅州、新泽西州和明尼苏达州依赖受砷污染家庭水井的社区的砷暴露。我们会 还将继续促进我们的SRP科学家、利益相关者和政府之间的有效沟通 合作伙伴通过五个具体战略。最后,我们将继续培养下一代科学家 纪律和跨学科技能,使他们能够改善居住在 可能使它们暴露于土壤、水和食物中的砷和其他污染物的环境。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Ana Navas-Acien其他文献

Ana Navas-Acien的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Ana Navas-Acien', 18)}}的其他基金

Columbia University and Northern Plains Partnership for the Superfund Research Program
哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系
  • 批准号:
    10707887
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Health Effects of Metals in Native American Communities: A Longitudinal Multi-omics Study
金属对美洲原住民社区健康的影响:一项纵向多组学研究
  • 批准号:
    10707904
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Research Experience and Training Coordination Core
研究经验和培训协调核心
  • 批准号:
    10707928
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Metal Exposure and Early Cardiovascular Risk in Adult E-Cigarette Users
成人电子烟使用者的金属暴露和早期心血管风险
  • 批准号:
    10616935
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Columbia University and Northern Plains Partnership for the Superfund Research Program
哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系
  • 批准号:
    10797600
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10354274
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Columbia University and Northern Plains Partnership for the Superfund Research Program
哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系
  • 批准号:
    10797697
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10707925
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Health Effects of Metals in Native American Communities: A Longitudinal Multi-omics Study
金属对美洲原住民社区健康的影响:一项纵向多组学研究
  • 批准号:
    10354271
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
Columbia University and Northern Plains Partnership for the Superfund Research Program
哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系
  • 批准号:
    10354268
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:

相似海外基金

Conference: Rethinking how language background is described in academia and beyond
会议:重新思考学术界及其他领域如何描述语言背景
  • 批准号:
    2335912
  • 财政年份:
    2024
  • 资助金额:
    $ 141.41万
  • 项目类别:
    Standard Grant
ADVANCE Catalyst: Virtual Observatory of Culture for Equity in Academia at the University of Puerto Rico Rio Piedras (VoCEA)
ADVANCE Catalyst:波多黎各 Rio Piedras 大学学术界平等文化虚拟观察站 (VoCEA)
  • 批准号:
    2214418
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
    Standard Grant
Comprehensive development strategy of modality-specific "intellectual property" and "cultivation" with an eye on "pharmaceutical affairs" in academia drug discovery
学术界新药研发着眼“药事”的模式“知识产权”与“培育”综合发展策略
  • 批准号:
    23K02551
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Accelerating Research Advancement for Investigators Underrepresented in Academia
加速学术界代表性不足的研究人员的研究进展
  • 批准号:
    10746315
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
Planning: HBCU-UP: Strengthening Data Science Research Capacity and Education Programs through Academia-Industry Partnership
规划:HBCU-UP:通过学术界与工业界合作加强数据科学研究能力和教育计划
  • 批准号:
    2332161
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
    Standard Grant
From Academia to Business: Development of Novel Therapeutics Against HPV-Associated Cancer
从学术界到商界:针对 HPV 相关癌症的新型疗法的开发
  • 批准号:
    10813323
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
Academics4Rail: Building a Community of Railway Scientific Researchers and Academia for ERJU and Enabling a Network of PhDs (Academia Teaming with Industry)
Academys4Rail:为二院建立铁路科研人员和学术界社区并启用博士网络(学术界与工业界合作)
  • 批准号:
    10102850
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
    EU-Funded
Academics4Rail: Building a community of railway scientific researchers and academia for ERJU and enabling a network of PhDs (academia teaming with industry)
Academys4Rail:为ERJU建立铁路科研人员和学术界社区并建立博士网络(学术界与工业界合作)
  • 批准号:
    10087488
  • 财政年份:
    2023
  • 资助金额:
    $ 141.41万
  • 项目类别:
    EU-Funded
Exploring the overall picture of industry-academia-government collaboration: A spectrum of knowledge transfer through formal and informal channels
探索产学官合作的整体图景:通过正式和非正式渠道进行的一系列知识转移
  • 批准号:
    22K01692
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project
促进道德神经技术学术界与工业界的伙伴关系:利益相关者参与和工具包开发项目
  • 批准号:
    10655632
  • 财政年份:
    2022
  • 资助金额:
    $ 141.41万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了