Mississippi Center for Clinical and Translational Research

密西西比临床和转化研究中心

• 批准号: 9334895
• 负责人: James Graham Wilson
• 金额: $ 397.62万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-18 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9334895
• 关键词: Address; Advisory Committees; Affect; African American; Basic Science; Biology; Biometry; Biostatistics Core; Blood Vessels; Caring; Center for Translational Science Activities; Cessation of life; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Data Analyses; Data Collection; Development; Diabetes Mellitus; Diagnosis; Diet; Discipline; Disease; Effectiveness; Ensure; Epidemiologist; Epidemiology; Ethics Consultation; Evaluation; Extramural Activities; Faculty; Funding; Genetic; Goals; Habits; Health; Heart; Historically Black Colleges and Universities; Industry; Institution; Interdisciplinary Study; Lead; Leadership; Life Style; Logistics; Louisiana; Malignant Neoplasms; Medical center; Mentorship; Mississippi; Monitor; National Institute of General Medical Sciences; Obesity; Observational Study; Office of Administrative Management; Outcome; Performance; Physicians; Pilot Projects; Prevention approach; Principal Investigator; Public Health; Recording of previous events; Reporting; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Allocation; Resources; Risk; Rural Community; Services; Structure; Time; Training; Training Support; Translational Research; United States; Universities; authority; cancer risk; cardiovascular disorder risk; college; data management; diabetes risk; diet and exercise; disorder risk; experience; faculty research; flexibility; health disparity; implementation research; improved; investigator training; member; mortality; next generation; novel strategies; nutrition; obesity treatment; programs; public health relevance; racial and ethnic disparities; research study; resource guides; success

 DESCRIPTION (provided by applicant): Obesity is associated with heightened risk of cardiovascular diseases, diabetes, and cancers, as well as increased all-cause mortality. Mississippi consistently ranks among the states with the highest rates of obesity, particularly among African Americans. The University of Mississippi Medical Center has a history of success in basic research, including obesity research, and observational studies, but historically has not been strong in clinical or translational research. This application describes a proposed "Mississippi Center for Clinical and Translational Research" (CCTR), which will be a partnership involving UMMC, the University of Southern Mississippi, and Tougaloo College, a historically black college/university. The CCTR will also pursue extensive collaboration with the IDeA-funded Louisiana Clinical and Translational Science Center, and Mayo Clinic's Center for Clinical and Translational Science. An Administrative Core with clear lines of authority and responsibility will be responsible for managing and coordinating the full range of CCTR activities. It will monitor progress toward project goals and milestones, and will have a flexible and responsible leadership and advisory structure that will allow it to realign resources to maximize the beneficial effects of the CCTR. A Community Advisory Board will provide bi-directional communication and guidance on community values, concerns, and needs, and will represent the CCTR to Mississippi communities. A Professional Development Core will offer structured mentorship, protected time for research, and substantial funding for obesity-focused research to junior faculty of all CCTR partners, and will offer training and support for community engaged research to develop the next generation of obesity investigators in Mississippi and increase the diversity of the research workforce. A Clinical Research, Epidemiology, and Biostatistics Core will provide extensive training and assistance with research design and implementation, data collection and management, data analysis, biostatistics, and epidemiology to increase the effectiveness, efficiency, and success of clinical and translational obesity research by CCTR faculty members. A Pilot Projects Program will support research projects that are likely to lead to extramural funding and sustained research success, and to improve obesity, related disorders, and health disparities. A Research Service Center will provide ethics consultation and extensive training and assistance with regulatory and administrative management and research implementation. A Tracking and Evaluation Core will provide extensive, accurate, and timely information on CCTR performance and impact to inform project planning and implementation by CCTR leadership and advisory bodies. By realizing the intentions stated above, the CCTR will develop a powerful and sustainable research enterprise that will have an important public health impact by reducing obesity and its complications and health disparities in Mississippi.

 描述（由适用提供）：肥胖与心血管疾病，糖尿病和癌症的风险增加以及全因死亡率增加有关。密西西比州始终在肥胖率最高的州中排名最高，尤其是在非裔美国人中。密西西比大学医学中心在包括肥胖研究和观察性研究在内的基础研究成功史上有一个成功的历史，但从历史上看，临床或翻译研究并不强。该申请描述了拟议的“密西西比州临床和转化研究中心”（CCTR），该中心将与UMMC，南密西西比大学和Tougaloo College（历史悠久的黑人学院/大学）有关。 CCTR还将与由Idea资助的路易斯安那州临床和转化科学中心以及Mayo诊所的临床与转化科学中心进行广泛的合作。具有明确权力和责任的行政核心将负责管理和协调CCTR活动的全部范围。它将监视对项目目标和里程碑的进步，并具有灵活，负责任的领导力和咨询结构，使其能够重新调整资源以最大程度地发挥CCTR的有益效果。社区顾问委员会将提供有关社区价值观，关注和需求的双向沟通​​和指导，并将代表密西西比州社区的CCTR。专业发展核心将为所有CCTR合作伙伴的初级教师提供结构化的心态，受保护的研究时间，并为肥胖症的研究提供大量资金，并将为社区参与的研究提供培训和支持，以发展密西西比州的下一代肥胖研究人员，并增加研究工作人员的多样性。临床研究，流行病学和生物统计学核心将在研究设计和实施，数据收集和管理，数据分析，生物统计学和流行病学方面提供广泛的培训和帮助，以提高CCTR教师的临床和转化肥胖研究的有效性，有效性和成功。一项试点项目计划将支持可能导致壁外资金和持续研究成功的研究项目，并改善肥胖，相关疾病和健康分布。研究服务中心将在监管和行政管理和研究实施方面提供道德咨询，广泛的培训和协助。跟踪和评估核心将提供有关CCTR性能和影响的广泛，准确和及时的信息，以告知CCTR领导力和咨询机构的项目计划和实施。通过意识到上述意图，CCTR将开发一个强大而可持续的研究企业，该企业将通过减少肥胖症及其并发症和健康差异来产生重要的公共卫生影响。