Computation and Informatics in Biology and Medicine

摘要 威斯康星大学(UW)生物与医学计算与信息学(CIBM)培训 计划建议继续培训具有深厚和广泛专业知识的下一代科学家 生物医学信息学。我们将扩大我们与马什菲尔德临床研究中心之前的合作 基金会(MCRF)作为培训赠款的合作伙伴，我们将使我们的学员能够发展他们的专业知识 并在充满活力的生物医学和数据科学生态系统中为他们的职业生涯奠定基础 在密歇根大学和MCRF的研究。威斯康星大学在研究支出方面排名全国第四 外部资助的研究组合超过10亿美元/年。这项研究的很大一部分是在 生物医学及相关领域，以及CIBM涉及的多个部门经常位居榜首 不同排名中的十大榜单，包括计算机科学、遗传学、生物化学、统计学、化学和 生物工程，以及其他。CIBM计划也与该中心保持着密切的关系 预测计算表型(NIH BD2K大数据计算卓越中心)， 临床和翻译研究所(NIH/NCATS资助的CTSA)，碳癌症中心， 和威斯康星州的基因组中心。我们的受训人员从从属关系和参与研究中受益 UW和MCRF这些单位和其他单位的项目。 我们将继续致力于为学员提供(I)强大的算法和量化基础， 计算机科学和统计学，(2)广泛了解关键的生物医学信息学方法和 挑战，以及(Iii)对生物医学背景的扎实理解，从分子到 患者群体，其中可以应用信息学的方法来获得洞察力并促进人类 健康。我们计划的主要组成部分包括(I)生物医学信息学的一套核心课程，(Ii)广泛的 一套辅助性选修课，(三)每周系列研讨会，(四)年度务虚会，(五)严格的道德培训 负责任地开展研究；(6)跨学科共同指导；(7)年度进展 与实习生会面。 我们在招收和培养研究生和博士后方面取得了很大成功。 我们培养的新教师和其他成功的专业人员的数量证明了这一点。 开发新的外部资助的多学科研究项目，以及我们在少数族裔的记录 招聘和安置。 我们最近和即将增加的项目包括几个新的教员培训师，一个新的硕士学位 生物医学信息学课程，与当地行业更紧密的联系，以及数据科学的新课程， 可重复的研究、生物医学图像分析、健康信息学和负责任的研究 数据科学家。 我们为我们的标准轨道招聘9个博士后职位和6个博士后培训职位，其中2个 为我们的环境暴露跟踪提供更多博士后职位。我们还要求提供4个短期的 实习生职位。 CIBM项目处于有利地位，可以为国家服务，拥有训练有素的研究人员，他们具有重要的 在计算机科学的基础学科--生物医学信息学方面的专业知识和实践经验 和统计学，以及这些方法可以应用于推动生物学和 改善人类健康。

Abstract The University of Wisconsin’s (UW) Computation and Informatics in Biology and Medicine (CIBM) training program is proposing to continue training the next generation of scientists with deep and broad expertise in biomedical informatics. We will extend our prior collaboration with the Marshfield Clinical Research Foundation (MCRF) as a partner in the training grant, and we will enable our trainees to develop their expertise and establish the foundations of their careers within a vibrant ecosystem of biomedical and data science research at UW and MCRF. The University of Wisconsin ranks fourth nationally in research expenditures with an externally funded research portfolio exceeding $1B/year. A significant fraction of this research is in the biomedical sciences and related areas, and a number of departments involved in CIBM are regularly in the ‘top ten’ lists in various rankings, including Computer Sciences, Genetics, Biochemistry, Statistics, Chemical and Biological Engineering, and others. The CIBM program also has close relationships to the Center for Predictive Computational Phenotyping (an NIH BD2K Center of Excellence for for Big Data Computing), the Institute for Clinical and Translational Research (a NIH/NCATS funded CTSA), the Carbone Cancer Center, and the Genome Center of Wisconsin. Our trainees benefit from affiliations and involvement in research projects in these and other units at UW and MCRF. We will continue our focus on providing trainees with (i) a strong algorithmic and quantitative foundation from computer science and statistics, (ii) a broad understanding of the key biomedical informatics methods and challenges, and (iii) a solid understanding of the biomedical contexts, spanning the spectrum from molecules to populations of patients, in which methods from informatics can be applied to gain insight and advance human health. Key components of our program include (i) a core set of courses in biomedical informatics, (ii) a broad set of supporting electives, (iii) a weekly seminar series, (iv) an annual retreat, (v) rigorous training in ethics and the responsible conduct of research, (vi) trans-disciplinary co-mentorship, and (vii) annual progress meetings with trainees. We have demonstrated strong success in recruiting and training graduate students and postdoctoral fellows. This is evidenced by the number of new faculty and other successful professionals we have produced, the development of new externally funded multi-disciplinary research projects, and our track record in minority recruitment and placement. Recent and forthcoming additions to our program include several new faculty trainers, a new MS degree program in Biomedical Informatics, stronger ties with local industry, and new courses in data science, reproducible research, biomedical image analysis, health informatics and responsible conduct of research for data scientists. We are asking for 9 predoctoral positions and 6 postdoctoral training positions for our standard tracks, with 2 additional postdoctoral positions for our environmental exposures track. We are also requesting 4 short-term trainee positions. The CIBM program is well positioned to serve the country with highly trained researchers who have significant expertise and practical experience in biomedical informatics, the foundational disciplines of computer science and statistics, and the biomedical contexts in which these methods can be applied to advance biology and improve human health.