Enhancing Intervention of Attenuated Psychosis Syndrome with M-Health Technology

“以移动健康科技加强对弱能精神病综合征的干预” 7.项目概要/摘要： 在世界范围内，对处于脓毒症前驱期或 衰减性精神病综合征（APS）阶段，主要由澳大利亚，欧洲和北美的研究人员领导 美国（“北美前驱症状纵向研究/NAPLS”）。在亚洲网络内， 精神病、台湾和新加坡已开始处理脓疱前驱人群。对我们 知识，我们是第一个在亚洲中低收入国家开展APS研究的研究小组， R21与上海市精神卫生中心（SMHC）合作（1 R21 MH 093294 - 01 A1，Fogarty/NIMH， “将精神病前驱症状的调查扩大到不同文化群体”）和R 01“验证 上海前驱症状和向精神病转变的生物标志物”（1 R 01 MH 101052-01，NIMH）。R21 R 01研究旨在早期发现APS及其危险因素。我们目前的建议，在 对NIH FOA（PAR-16-292）移动的健康：低收入和中等收入的技术和成果的回应 国家（R21）将重点关注针对神经认知功能-记忆和注意力的早期干预工作 特别是使用移动健康技术。我们将开发和实施具有文化敏感性的智能手机 应用于使APS患者参与改善神经认知和社会功能。我们的目标是 与SMHC的研究人员合作，建立他们在建立可持续APS方面的研究能力 纵向研究计划，为APS早期干预与mHealth奠定基础 技术.该项目将分两个阶段完成：第一阶段（1-7个月），开发和测试特定的 记忆注意力资源和训练（SMART）的应用，通过定性研究方法， 深度1：1访谈第二阶段（8-24个月），我们将首先检查SMART的可行性和用户参与度 采用混合方法设计。我们将对80名APS受试者（年龄18-45岁）进行初步研究。40名受试者将 接受常规护理（RC），40名年龄、性别、临床症状匹配的患者将接受额外的SMART治疗， 除了RC，还有几个月。在基线和3个月随访时，所有受试者将在app上完成问卷 对SMART可行性和参与度的习惯和态度，以及MATRICS认知测试 测量工作记忆和注意力的子测试。驻地协调员小组将提出他们对解决 使用SMART的可能性。将在两个时间点进行深入访谈，以交叉验证 从问卷调查中获得的结果。其次，我们将研究认知和社会功能的变化 随着时间的推移与组内和组间设计。第三，我们努力建立移动健康研究能力， 个人和组织的水平，并在赠款时间之后。

“Enhancing Intervention of Attenuated Psychosis Syndrome with M-Health Technology” 7. Project Summary/Abstract: There is a worldwide movement in the early intervention of populations at the putatively prodromal or attenuated psychosis syndrome (APS) stage, led mainly by researchers in Australia, Europe, and North America (“North American Prodrome Longitudinal Studies/NAPLS). Within the Asian Network for Early Psychosis, Taiwan and Singapore have started to address the putatively prodromal population. To our knowledge, we are the first research group carrying out APS studies in a low-middle income country in Asia, an R21 in collaboration with the Shanghai Mental Health Center (SMHC) (1R21MH093294-01A1, Fogarty/NIMH, “Broadening the Investigation of Psychosis Prodrome to Different Cultural Groups”), and an R01 “Validating Biomarkers for the Prodrome and Transition to Psychosis in Shanghai” (1 R01 MH 101052-01, NIMH). The R21 and R01 studies aim at early identification of APS and the risk factors of APS. Our current proposal, in response to the NIH FOA (PAR-16-292) Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21), will focus on early intervention effort targeting neurocognitive function-memory and attention in particular, using mHealth technology. We will develop and implement a culturally sensitive smart phone application to engage patients with APS in improving neurocognitive and social functioning. Our goal is to work collaboratively with researchers at the SMHC to build their research capacity in establishing a sustainable APS longitudinal program of research in China and to lay a foundation for APS early intervention with mHealth technology. This project will be completed in two phases: Phase 1 (Month 1-7), Develop and test the Specific Memory Attention Resource and Training (SMART) application through a qualitative research approach-in- depth 1:1 interviews. Phase 2 (Month 8-24), we will firstly examine SMART feasibility and user engagement with a mixed method design. We will conduct a pilot study of 80 APS subjects (age 18-45). Forty subjects will get routine care (RC) and 40 matched by age, gender, clinical symptoms will receive add-on SMART for 3 months in addition to RC. At baseline and 3-month follow-ups, all subjects will complete questionnaires on app use habits and attitudes towards SMART feasibility and engagement, and MATRICS Cognitive Battery subtests measuring working memory and attention. The RC group will provide their attitudes addressing the likelihood of using SMART. In-depth interviews will be conducted at both time points to cross-validate the findings obtained from the questionnaires. Secondly we will examine cognitive and social function changes over time with the within and between group design. Thirdly, we strive to build mHealth research capacity at individual and organization levels during and beyond grant time.