Core B: Administrative Core

核心 B：行政核心

• 批准号: 9209575
• 负责人: EMERY N BROWN
• 金额: $ 7.47万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-10 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9209575
• 关键词: Absence of pain sensation; Address; Adrenergic Agonists; Advisory Committees; Amnesia; Anesthesia procedures; Anesthetics; Arousal; Behavioral; Biomedical Engineering; Boston; Brain; Collaborations; Data Analyses; Dexmedetomidine; Drug effect disorder; Electroencephalography; General Anesthesia; General Hospitals; Goals; Hallucinations; Human; Ketamine; Lead; Massachusetts; Molecular Target; NMDA receptor antagonist; Neurologist; Neurosciences; Neurosurgeon; Occupational activity of managing finances; Office of Administrative Management; Operative Surgical Procedures; Patients; Performance; Pharmaceutical Preparations; Physiological; Propofol; Research; Rodent Model; Sedation procedure; Statistical Methods; Study models; System; Unconscious State; United States; Universities; fascinate; man; meetings; molecular site; neural circuit; neurophysiology; nonhuman primate; programs; relating to nervous system; sevoflurane

CORE B. ADMINISTRATIVE CORE General anesthesia is a fascinating man-made, neurophysiological phenomenon that has been developed empirically over many years to enable safe and humane performance of surgical and non-surgical procedures. Specifically it is a drug-induced condition consisting of unconsciousness, amnesia, analgesia and immobility, along with physiological stability. General anesthesia is administered daily to 60,000 patients in the United States, the mechanisms for how anesthetics act in the brain to create the states of anesthesia are not well understood. Significant progress has been made recently in characterizing the molecular sites that anesthetics target. However, how actions at specific molecular targets lead to the behavioral states is less well understood. Addressing this issue requires a systems neuroscience approach to define how actions of the drugs at specific molecular targets and neural circuits lead to a behavioral state of general anesthesia. In this program project entitled, Integrated Systems Neuroscience Studies of Anesthesia, we will develop an integrated systems neuroscience program consisting of human, non-human primate, rodent and modeling studies of four anesthetics: the GABAA agents, propofol and sevoflurane; the alpha-2 adrenergic agonist, dexmedetomidine; and the NMDA receptor antagonist, ketamine. The program project will also include a DATA ANALYSIS CORE, which will provide assistant with data analysis and conduct research on statistical methods. The Specific Aims are to understand how the actions of the anesthetics at specific molecular targets and neural circuits produce the oscillatory dynamics (EEG rhythms, changes in LFPs and neural spiking activity) that are likely a primary common mechanism through which anesthetics create altered states of arousal (sedation, hallucination, unconsciousness). This program project will be a unique research collaboration among anesthesiologists, neuroscientists, bioengineers, a neurosurgeon, a neurologist, a statistician and a mathematician at Massachusetts General Hospital and Boston University. The day-to-day management of this program project will require an active team of support staff to accomplish its several goals. The responsibilities of the administrative core will include day-to-day administrative and financial management, along with planning of bi- weekly program project meetings, bi-weekly Executive Committee meetings, and planning of the annual Scientific Advisory Committee meeting.

核心b.行政核心