Core B: Administrative Core

核心 B:行政核心

基本信息

  • 批准号:
    10093065
  • 负责人:
  • 金额:
    $ 9.26万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-02-10 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

CORE B. ADMINISTRATIVE CORE General anesthesia is a fascinating man-made, neurophysiological phenomenon that has been developed empirically over many years to enable safe and humane performance of surgical and non-surgical procedures. Specifically it is a drug-induced condition consisting of unconsciousness, amnesia, analgesia and immobility, along with physiological stability. General anesthesia is administered daily to 60,000 patients in the United States, the mechanisms for how anesthetics act in the brain to create the states of anesthesia are not well understood. Significant progress has been made recently in characterizing the molecular sites that anesthetics target. However, how actions at specific molecular targets lead to the behavioral states is less well understood. Addressing this issue requires a systems neuroscience approach to define how actions of the drugs at specific molecular targets and neural circuits lead to a behavioral state of general anesthesia. In this program project entitled, Integrated Systems Neuroscience Studies of Anesthesia, we will develop an integrated systems neuroscience program consisting of human, non-human primate, rodent and modeling studies of four anesthetics: the GABAA agents, propofol and sevoflurane; the alpha-2 adrenergic agonist, dexmedetomidine; and the NMDA receptor antagonist, ketamine. The program project will also include a DATA ANALYSIS CORE, which will provide assistant with data analysis and conduct research on statistical methods. The Specific Aims are to understand how the actions of the anesthetics at specific molecular targets and neural circuits produce the oscillatory dynamics (EEG rhythms, changes in LFPs and neural spiking activity) that are likely a primary common mechanism through which anesthetics create altered states of arousal (sedation, hallucination, unconsciousness). This program project will be a unique research collaboration among anesthesiologists, neuroscientists, bioengineers, a neurosurgeon, a neurologist, a statistician and a mathematician at Massachusetts General Hospital and Boston University. The day-to-day management of this program project will require an active team of support staff to accomplish its several goals. The responsibilities of the administrative core will include day-to-day administrative and financial management, along with planning of bi- weekly program project meetings, bi-weekly Executive Committee meetings, and planning of the annual Scientific Advisory Committee meeting.
核心B.行政核心 全麻是一种令人着迷的人造神经生理现象,已经发展起来。 多年来的经验证明,能够安全和人性化地执行手术和非手术程序。 具体地说,它是一种由药物引起的状态,包括意识丧失、健忘、止痛和静止, 以及生理稳定性。在美国,每天有6万名患者接受全身麻醉 麻醉剂如何在大脑中产生麻醉状态的机制还不是很好。 明白了。最近在表征麻醉药的分子位置方面取得了重大进展 目标。然而,对特定分子靶标的作用如何导致行为状态还不太清楚。 解决这一问题需要系统神经科学方法来定义药物在特定情况下的作用 分子靶点和神经回路导致全身麻醉的行为状态。在该计划项目中 题为《麻醉的集成系统神经科学研究》,我们将开发一个集成系统 神经科学项目包括人类、非人灵长类、啮齿动物和四个模型研究 麻醉药:GABAA类药物异丙酚和七氟醚,α-2肾上腺素能激动剂右旋美托咪定; 以及NMDA受体拮抗剂氯胺酮。该计划项目还将包括数据分析核心, 它将为数据分析提供辅助,并对统计方法进行研究。具体目标 是为了了解麻醉剂对特定分子靶点和神经回路的作用是如何产生的 振荡动力学(脑电节律、LFP的变化和神经放电活动)可能是主要的 麻醉剂产生不同的唤醒状态(镇静、幻觉、 无意识)。该计划项目将是麻醉师之间独特的研究合作, 神经科学家、生物工程师、神经外科医生、神经学家、统计学家和数学家 马萨诸塞州总医院和波士顿大学。本计划项目的日常管理 将需要一支积极的支持团队来实现其几个目标。该委员会的职责 行政核心将包括日常行政和财务管理,以及规划双 每周一次的计划项目会议,每两周一次的执行委员会会议,以及年度计划 科学咨询委员会会议。

项目成果

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EMERY N BROWN其他文献

EMERY N BROWN的其他文献

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{{ truncateString('EMERY N BROWN', 18)}}的其他基金

Investigating the neurophysiological basis of circuit-specific laminar rs-fMRI
研究电路特异性层流 rs-fMRI 的神经生理学基础
  • 批准号:
    10518479
  • 财政年份:
    2022
  • 资助金额:
    $ 9.26万
  • 项目类别:
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
  • 批准号:
    10610946
  • 财政年份:
    2022
  • 资助金额:
    $ 9.26万
  • 项目类别:
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
用于开发闭环麻醉输送系统的非人类灵长类动物模型
  • 批准号:
    10445654
  • 财政年份:
    2022
  • 资助金额:
    $ 9.26万
  • 项目类别:
Core B: Administrative Core
核心 B:行政核心
  • 批准号:
    9209575
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:
Project 1: Human Studies of Anesthetic Action
项目 1:麻醉作用的人体研究
  • 批准号:
    10093071
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
  • 批准号:
    10093061
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:
The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
全身麻醉下老化的大脑:神经生理学、衰老和阿尔茨海默病的神经影像生物标志物以及术后认知结果
  • 批准号:
    9904463
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:
Thalamocortical Dynamics and Consciousness
丘脑皮质动力学和意识
  • 批准号:
    10199752
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:
Integrated Systems Neuroscience Studies of Anaesthesia
麻醉的综合系统神经科学研究
  • 批准号:
    9209574
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:
Core A: Data Analysis Core
核心A:数据分析核心
  • 批准号:
    10093068
  • 财政年份:
    2017
  • 资助金额:
    $ 9.26万
  • 项目类别:

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