Core B: Administrative Core

核心 B：行政核心

• 批准号: 10093065
• 负责人: EMERY N BROWN
• 金额: $ 9.26万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-10 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10093065
• 关键词: Absence of pain sensation; Address; Adrenergic Agonists; Advisory Committees; Amnesia; Anesthesia procedures; Anesthetics; Arousal; Behavioral; Biomedical Engineering; Boston; Brain; Collaborations; Data Analyses; Dexmedetomidine; Electroencephalography; General Anesthesia; General Hospitals; Goals; Hallucinations; Human; Ketamine; Lead; Massachusetts; Molecular Target; NMDA receptor antagonist; Neurologist; Neurosciences; Neurosurgeon; Occupational activity of managing finances; Office of Administrative Management; Operative Surgical Procedures; Patients; Performance; Pharmaceutical Preparations; Physiological; Propofol; Research; Rodent Model; Sedation procedure; Statistical Methods; Study models; System; Unconscious State; United States; Universities; drug action; fascinate; man; meetings; molecular site; neural circuit; neurophysiology; nonhuman primate; programs; relating to nervous system; sevoflurane

CORE B. ADMINISTRATIVE CORE General anesthesia is a fascinating man-made, neurophysiological phenomenon that has been developed empirically over many years to enable safe and humane performance of surgical and non-surgical procedures. Specifically it is a drug-induced condition consisting of unconsciousness, amnesia, analgesia and immobility, along with physiological stability. General anesthesia is administered daily to 60,000 patients in the United States, the mechanisms for how anesthetics act in the brain to create the states of anesthesia are not well understood. Significant progress has been made recently in characterizing the molecular sites that anesthetics target. However, how actions at specific molecular targets lead to the behavioral states is less well understood. Addressing this issue requires a systems neuroscience approach to define how actions of the drugs at specific molecular targets and neural circuits lead to a behavioral state of general anesthesia. In this program project entitled, Integrated Systems Neuroscience Studies of Anesthesia, we will develop an integrated systems neuroscience program consisting of human, non-human primate, rodent and modeling studies of four anesthetics: the GABAA agents, propofol and sevoflurane; the alpha-2 adrenergic agonist, dexmedetomidine; and the NMDA receptor antagonist, ketamine. The program project will also include a DATA ANALYSIS CORE, which will provide assistant with data analysis and conduct research on statistical methods. The Specific Aims are to understand how the actions of the anesthetics at specific molecular targets and neural circuits produce the oscillatory dynamics (EEG rhythms, changes in LFPs and neural spiking activity) that are likely a primary common mechanism through which anesthetics create altered states of arousal (sedation, hallucination, unconsciousness). This program project will be a unique research collaboration among anesthesiologists, neuroscientists, bioengineers, a neurosurgeon, a neurologist, a statistician and a mathematician at Massachusetts General Hospital and Boston University. The day-to-day management of this program project will require an active team of support staff to accomplish its several goals. The responsibilities of the administrative core will include day-to-day administrative and financial management, along with planning of bi- weekly program project meetings, bi-weekly Executive Committee meetings, and planning of the annual Scientific Advisory Committee meeting.

核心B。行政核心 全身麻醉是一个迷人的人造，神经生理学现象，已开发 多年来的经验，以实现安全和人道的手术和非手术程序的性能。 具体来说，它是一种药物诱导的疾病，包括无意识、健忘、镇痛和不动， 沿着生理稳定性。在美国，每天有60，000名患者接受全身麻醉 关于麻醉剂在大脑中如何作用以产生麻醉状态的机制， 明白近年来，在麻醉剂作用的分子位点的表征方面取得了重大进展， 目标然而，在特定的分子靶点上的作用如何导致行为状态还不太清楚。 解决这个问题需要一个系统神经科学的方法来定义药物的作用，在特定的 分子靶点和神经回路导致全身麻醉的行为状态。在这个项目中， 名为“麻醉的集成系统神经科学研究”，我们将开发一个集成系统， 神经科学计划，包括人类，非人类灵长类动物，啮齿动物和建模研究的四个 麻醉剂：GABAA药物，丙泊酚和七氟烷; α-2肾上腺素能激动剂，右美托咪定; 和NMDA受体拮抗剂氯胺酮该计划项目还将包括一个数据分析核心， 协助进行数据分析和统计方法研究。具体目标 是为了了解麻醉剂在特定分子靶点和神经回路中的作用， 振荡动力学（EEG节律，LFP和神经尖峰活动的变化）可能是主要的 麻醉剂通过其产生改变的唤醒状态（镇静，幻觉， 无意识）。该计划项目将是麻醉师之间的独特研究合作， 神经科学家，生物工程师，神经外科医生，神经学家，统计学家和数学家， 马萨诸塞州总医院和波士顿大学。本项目的日常管理 将需要一个积极的支持人员团队来实现其几个目标。的责任 行政核心将包括日常行政和财务管理，沿着双边规划， 每周计划项目会议，双周执行委员会会议，以及年度计划 科学咨询委员会会议。