Achieving a Nationally Integrated Food Safety System: Maintaining and Enhancing ISO/IEC 17025 Accreditation at the CT Agricultural Experiment Station

标题-“实现全国一体化的食品安全体系：维护和 提升CT农业试验站的ISO/IEC 17025认证” 项目摘要-本提案是根据RFA-FD-17-010提交的 “维持和加强ISO/IEC 17025认证和全基因组测序 国家食品检测实验室”，特别是作为竞争A的一部分：ISO/IEC 17025 认证维护和增强。康涅狄格州农业实验站 分析化学系（DAC）拥有142年的食品安全历史 研究，包括12年作为FDA食品紧急反应网络（FERN）的成员 化学合作协议计划（cCAP）和“ISO/IEC”下的5年资助 17025：2005食品检测实验室认证”合作协议计划 （CAP）。在后一项计划下，CAES DAC获得了由 美国实验室认证协会（A2 LA）于2016年12月。除了 作为康涅狄格州唯一一家为MFRPS计划提供化学测试的实验室， CAES DAC参与更广泛的监督和监测计划，以确保 在CT状态下的食物。该提案的主要目标是获得必要的资金， 保持和加强实验室ISO/IEC 17025认证，以支持FDA的努力， 建立全国统一的粮食体系。具体而言，该CAP将确保化学食品 代表国家制造食品监管计划的分析是在 ISO/IEC 17025认证实验室的范围，将加强 CAES DAC和国家制造的监管计划，并将增加国家 每年收集和分析用于监测目的的CT样本。 实验室目前的认证范围包括CAES DAC“市场篮子” 程序.该计划是在与消费者CT部门协调进行 保护（DCP），包括FDA MFRPS计划。目前，食品样本收集 由DCP检查员每年检查一次，并带到CAES DAC进行化学分析。样品 进行经验证的内部均质化和提取/消化方案， 通过气相色谱-质谱检测（GC/MS/MS）分析农药 和通过液相色谱-高分辨率质谱检测（LC/HRMS）。 另外，通过电感耦合等离子体质谱法分析选定样品的总砷 质谱法（ICP/MS）。在认证范围内需要分析的食品基质包括 那些通常在我们的市场篮子调查中遇到的，其中包括果汁，苹果酒，婴儿食品， 和其他加工水果/蔬菜。拟议的 工作在我们的研究策略中有详细说明，但将涉及扩大认证范围 额外的食物基质，以及额外的农药和重金属，并且还专门 努力满足即将发布的ISO 17025：2017标准。 CAES DAC已证明其专业知识、能力和适应性， 通过成功参与“ISO/IEC 17025：2005”， 食品检测实验室认证”CAP和通过我们12年的工作作为一个FERN CCAP实验室获得FDA的这一新奖项将大大提高 特别是CAES DAC和CT，以满足RFA中规定的计划目标， 如食品安全任务计划、食品保护伙伴关系和 《食品安全现代化法》。

Title- “Achieving a Nationally Integrated Food Safety System: Maintaining and Enhancing ISO/IEC 17025 Accreditation at the CT Agricultural Experiment Station” Project Summary- This proposal is being submitted in response to RFA-FD-17-010 “Maintenance and enhancement of ISO/IEC 17025 Accreditation and Whole Genome Sequencing for State Food Testing Laboratories,” specifically as part of Competition A: ISO/IEC 17025 Accreditation Maintenance and Enhancement. The Connecticut Agricultural Experiment Station (CAES) Department of Analytical Chemistry (DAC) has a 142-year history of food safety research, including 12 years as a member of the FDA Food Emergency Response Network (FERN) Chemistry Cooperative Agreement Program (cCAP) and 5 years of funding under the “ISO/IEC 17025:2005 Accreditation for Food Testing Laboratories” Cooperative Agreement Program (CAP). Under the latter program, the CAES DAC was awarded ISO 17025 Accreditation by the American Association for Laboratory Accreditation (A2LA) in December 2016. In addition to being the sole laboratory in Connecticut providing chemical testing for the MFRPS program, the CAES DAC participates a broader surveillance and monitoring program to ensure the safety of food in the state of CT. The primary goal of this proposal is to acquire the necessary funding to maintain and enhance the laboratories ISO/IEC 17025 accreditation so as to support FDA effort to establish a nationally integrated food system. Specifically, this CAP will ensure that chemical food analyses on behalf of the State manufactured food regulatory programs are conducted within the scope of an ISO/IEC 17025 accredited laboratory, will strengthen the collaboration between lthe CAES DAC and the State manufactured regulatory program, and will increase the number of State of CT samples collected and analyzed for surveillance purposes annually. The laboratories current scope of accreditation covers CAES DAC “Market Basket” program. This program is conducted in coordination with the CT Department of Consumer Protection (DCP) and includes the FDA MFRPS Program. Currently, food samples are collected annually by DCP inspectors and brought to the CAES DAC for chemical analysis. The samples are subjected to validated in-house homogenization and extraction/digestion protocols, followed by analysis for pesticides by gas chromatography with mass spectrometric detection (GC/MS/MS) and by liquid chromatography with high resolution mass spectrometric detection (LC/HRMS). Separately, select samples are analyzed for total arsenic by inductively coupled plasma mass spectrometry (ICP/MS). The food matrices to be analyzed under the scope of accreditation are those typically encountered in our Market Basket survey, which includes juices, ciders, baby food, and other processed fruits/vegetables. The maintenance and enhancement portion of the proposed work is detailed in our Research Strategy but will involve expansion of the scope of accreditation to additional food matrices, as well as to additional pesticides and heavy metals, and also dedicated efforts to meet the soon to be released ISO 17025:2017 standard. The CAES DAC has demonstrated the expertise, capability, and adaptability to fully meet the objectives of this RFA through our successful participation in the “ISO/IEC 17025:2005 Accreditation for Food Testing Laboratories” CAP and through our 12 years of work as a FERN cCAP laboratory. Receipt of this new award from FDA will significantly enhance the ability of the CAES DAC specifically, and CT in general, to meet the program goals laid out in the RFA, and as described by the Food Safety Task For Program, the Partnership for Food Protection and the Food Safety Modernization Act.