Achieving a Nationally Integrated Food Safety System: Maintaining and Enhancing ISO/IEC 17025 Accreditation at the CT Agricultural Experiment Station

标题-“实现国家一体化食品安全体系：维护和 加强CT农业试验站的ISO/IEC 17025认证” 项目摘要 - 该提案是为了响应 RFA-FD-17-010 而提交的 “ISO/IEC 17025 认证和全基因组测序的维护和增强 国家食品检测实验室”，特别是作为竞赛 A 的一部分：ISO/IEC 17025 认证维护和增强。康涅狄格州农业实验站 (CAES) 分析化学系 (DAC) 拥有 142 年食品安全历史 研究，包括作为 FDA 食品紧急响应网络 (FERN) 成员 12 年 化学合作协议计划 (cCAP) 和“ISO/IEC”下的 5 年资助 17025:2005 食品检测实验室认可合作协议计划 （CAP）。根据后一个计划，CAES DAC 获得了 ISO 17025 认证 美国实验室认可协会 (A2LA)，2016 年 12 月。除了 作为康涅狄格州唯一为 MFRPS 计划提供化学测试的实验室， CAES DAC 参与更广泛的监视和监测计划，以确保人员的安全 CT状态下的食物。该提案的主要目标是获得必要的资金 维持和加强实验室 ISO/IEC 17025 认证，以支持 FDA 的努力 建立全国统一的粮食体系。具体来说，该 CAP 将确保化学食品 代表国家制造的食品监管计划的分析是在 ISO/IEC 17025 认可实验室的范围，将加强各实验室之间的合作 CAES DAC 和州制定了监管计划，并将增加州的数量 每年收集和分析用于监测目的的 CT 样本。 实验室目前的认证范围涵盖 CAES DAC“市场篮子” 程序。该计划是与 CT 消费者部门协调进行的 保护 (DCP) 并包括 FDA MFRPS 计划。目前，食品样本正在采集中 每年由 DCP 检查员检查并带到 CAES DAC 进行化学分析。样品 经过验证的内部均质化和提取/消化方案，然后 通过气相色谱和质谱检测 (GC/MS/MS) 分析农药 以及通过液相色谱法和高分辨率质谱检测 (LC/HRMS)。 单独地，通过电感耦合等离子体质量分析选定样品的总砷 光谱分析（ICP/MS）。在认可范围内进行分析的食品基质是 我们的市场购物篮调查中通常遇到的那些，其中包括果汁、苹果酒、婴儿食品、 和其他加工水果/蔬菜。拟议的维护和增强部分 我们的研究策略中详细介绍了工作，但将涉及扩大认证范围 额外的食品基质，以及额外的农药和重金属，并且还专门 努力满足即将发布的 ISO 17025:2017 标准。 CAES DAC 展示了其专业知识、能力和适应性，可以完全满足 通过我们成功参与“ISO/IEC 17025:2005 食品检测实验室认证”CAP 以及我们作为 FERN 12 年的工作 cCAP实验室。获得 FDA 的这一新奖项将显着增强 特别是 CAES DAC，以及一般 CT，以满足 RFA 中规定的计划目标， 正如食品安全任务计划、食品保护伙伴关系和 食品安全现代化法案。

Title- “Achieving a Nationally Integrated Food Safety System: Maintaining and Enhancing ISO/IEC 17025 Accreditation at the CT Agricultural Experiment Station” Project Summary- This proposal is being submitted in response to RFA-FD-17-010 “Maintenance and enhancement of ISO/IEC 17025 Accreditation and Whole Genome Sequencing for State Food Testing Laboratories,” specifically as part of Competition A: ISO/IEC 17025 Accreditation Maintenance and Enhancement. The Connecticut Agricultural Experiment Station (CAES) Department of Analytical Chemistry (DAC) has a 142-year history of food safety research, including 12 years as a member of the FDA Food Emergency Response Network (FERN) Chemistry Cooperative Agreement Program (cCAP) and 5 years of funding under the “ISO/IEC 17025:2005 Accreditation for Food Testing Laboratories” Cooperative Agreement Program (CAP). Under the latter program, the CAES DAC was awarded ISO 17025 Accreditation by the American Association for Laboratory Accreditation (A2LA) in December 2016. In addition to being the sole laboratory in Connecticut providing chemical testing for the MFRPS program, the CAES DAC participates a broader surveillance and monitoring program to ensure the safety of food in the state of CT. The primary goal of this proposal is to acquire the necessary funding to maintain and enhance the laboratories ISO/IEC 17025 accreditation so as to support FDA effort to establish a nationally integrated food system. Specifically, this CAP will ensure that chemical food analyses on behalf of the State manufactured food regulatory programs are conducted within the scope of an ISO/IEC 17025 accredited laboratory, will strengthen the collaboration between lthe CAES DAC and the State manufactured regulatory program, and will increase the number of State of CT samples collected and analyzed for surveillance purposes annually. The laboratories current scope of accreditation covers CAES DAC “Market Basket” program. This program is conducted in coordination with the CT Department of Consumer Protection (DCP) and includes the FDA MFRPS Program. Currently, food samples are collected annually by DCP inspectors and brought to the CAES DAC for chemical analysis. The samples are subjected to validated in-house homogenization and extraction/digestion protocols, followed by analysis for pesticides by gas chromatography with mass spectrometric detection (GC/MS/MS) and by liquid chromatography with high resolution mass spectrometric detection (LC/HRMS). Separately, select samples are analyzed for total arsenic by inductively coupled plasma mass spectrometry (ICP/MS). The food matrices to be analyzed under the scope of accreditation are those typically encountered in our Market Basket survey, which includes juices, ciders, baby food, and other processed fruits/vegetables. The maintenance and enhancement portion of the proposed work is detailed in our Research Strategy but will involve expansion of the scope of accreditation to additional food matrices, as well as to additional pesticides and heavy metals, and also dedicated efforts to meet the soon to be released ISO 17025:2017 standard. The CAES DAC has demonstrated the expertise, capability, and adaptability to fully meet the objectives of this RFA through our successful participation in the “ISO/IEC 17025:2005 Accreditation for Food Testing Laboratories” CAP and through our 12 years of work as a FERN cCAP laboratory. Receipt of this new award from FDA will significantly enhance the ability of the CAES DAC specifically, and CT in general, to meet the program goals laid out in the RFA, and as described by the Food Safety Task For Program, the Partnership for Food Protection and the Food Safety Modernization Act.