Cochlear angiogenesis

耳蜗血管生成

• 批准号: 9298262
• 负责人: Xiaorui Shi
• 金额: $ 23.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9298262
• 关键词: Address; Aging; Angiogenic Factor; Antigens; Basement membrane; Blood Vessels; Blood capillaries; Blood flow; Brain; Bromodeoxyuridine; Cells; Clinical; Cochlea; Communication; Confocal Microscopy; Coupling; Dependovirus; Disease; Ear; Endothelial Cells; Endothelial Growth Factors; Energy Supply; Fluorescence; Gene Delivery; Gene Transfer; Genes; Genetic; Genetic Enhancer Element; Goals; Hair Cells; Health; Hearing; Hearing problem; Homeostasis; Hormones; Human; Hypoxia; Immunologics; In Vitro; Individual; Injury; Ions; Label; Labyrinth; Life; Loudness; Maintenance; Measures; Membrane Proteins; Mesenchymal Stem Cells; Modeling; Mus; Natural regeneration; Neurologic; Neurons; Neurophysiology - biologic function; Norrie' s disease; Nuclear; Optical Coherence Tomography; Optics; Organ; Pathologic; Pathology; Pericytes; Pharmacology; Population; Proliferating; Proteins; Quality of life; Recovery; Recovery of Function; Reporter; Research; Resolution; Response Elements; Sensory; Signal Transduction; Social isolation; Source; Staining method; Stains; Stress; Structure; Sudden Deafness; Testing; Therapeutic; Tight Junctions; Time; Tissues; Tracer; Transgenic Organisms; Vascular Diseases; Vascular Endothelial Growth Factors; Vascular Permeabilities; Vascular blood supply; Vimentin; angiogenesis; base; capillary; density; hearing impairment; improved; in vivo; innovation; matrigel; microangiography; mouse model; nestin protein; neurogenesis; neuroregulation; neurotrophic factor; neutralizing monoclonal antibodies; novel; peripheral blood; postnatal; progenitor; promoter; receptor; regenerative; relating to nervous system; repaired; restoration; sound; success; vector

PROJECT SUMMARY Energy supply to the ear is critical for hearing function since the ear is one of the highest energy consuming organs. Insufficient energy can result from insufficient blood flow to the cochlea contributing to a wide range of clinical hearing disorders such as loud sound-induced hearing loss, hearing loss related to ageing, and sudden deafness, which can largely impact the quality of human life by causing individual communication problems and social isolation. We believe that success in repair and regeneration of hearing function following loss of sensory cells requires parallel restoration or maintenance of an efficient blood supply. Most recent evidence has shown a highly interplay between pathological-induced neurogenesis and angiogenesis. Angiogenesis in brain has been shown to be critical in coupling of improving neurological functional recovery after injury. The objective of this two year application is to develop a therapeutic strategy for improving cochlear ion homeostasis, particularly focused on restoring microvascular function. Our specific goal is to determine the regenerative capacity of the vasculature in the mouse cochlea. Ultimately this research will lead to innovative treatments for hearing loss involving disruption of cochlear homeostasis in peripheral blood flow.

项目摘要 对耳朵的能量供应对于听力功能是至关重要的，因为耳朵是最高能量消耗之一。 机关能量不足可能是由于流向耳蜗的血流不足导致的，从而导致大范围的听力损失。 临床听力障碍，如响亮的声音引起的听力损失，与衰老有关的听力损失，以及突发性听力损失。 耳聋，会导致个人沟通问题，从而在很大程度上影响人类的生活质量 和社会孤立。我们相信，在听力损失后， 感觉细胞需要平行恢复或维持有效的血液供应。最新证据 已经显示出病理诱导的神经发生和血管生成之间的高度相互作用。血管生成 已经显示脑在改善损伤后神经功能恢复的偶联中是关键的。的 这项为期两年的申请的目的是开发一种治疗策略， 体内平衡，特别是专注于恢复微血管功能。我们的具体目标是确定 小鼠耳蜗血管系统的再生能力。最终，这项研究将带来创新 涉及外周血流中耳蜗稳态破坏的听力损失的治疗。