Network for Investigation of Delirium across the U.S. (NIDUS)

谵妄是一种急性注意力和认知障碍，是一种常见的，危及生命的， 老年人可预防的临床综合征。鉴于其对功能和生活质量的不利影响， 谵妄对个人、家庭、社区和社会具有巨大的医疗保健和社会影响， 医疗保健系统。尽管其重要性，在诊断，病理生理学， 治疗一直滞后，迫切需要更有效的方法来促进 领域响应RFA-AG-16-009，我们建议开发一个合作研究网络， NIDUS（美国谵妄调查网络），通过一个 有目的的，协调的努力。我们的具体目标是：（1）建立和维护一个数据库， 元素，并提供一个有效的平台，以加强内部和内部的数据和生物标本共享， 在拟议的网络之外，促进多地点合作、二次分析和试点研究， 催化该领域;（2）开发谵妄识别，诊断和治疗的核心措施库， 严重程度，并协调所有类型的谵妄研究的数据;（3）支持试点研究，以鼓励 创新研究，针对优先领域（风险因素/预后;病理生理学/生物标志物;诊断 工具/现象学;和临床干预）;（4）指导对谵妄感兴趣的初级研究者 通过培训项目、教育资源和融入网络活动进行研究;（5） 传播有关研究资源、数据共享、培训机会和潜力的信息 及时有效地与相关利益攸关方和更广泛的科学界进行合作， 社区这些协同目标将利用积累的研究专业知识，超过28谵妄 领导人（12名共同研究者/指导委员会成员和16名科学咨询委员会成员） 这些机构（已承诺提供实物支助），以创建NIDUS协作网络。NIDUS将 提供具有2个资源核心的研究基础设施，以提供：（1）研究资源目录/ 数据库和（2）核心谵妄措施的储存库。将增加3个工作队 提供：（1）试点赠款，（2）辅导和职业发展支助，（3）传播 通过许多方法获得信息（例如，科学研讨会、年度会议和社交媒体）。病灶 将创建一个独特的国家资源，将促进和催化谵妄研究的创新， 提供核心资源和培训，针对优先领域，促进跨学科合作， 机构，参与和指导跨领域的初级研究人员，并传播研究成果 广泛而有效。汇集不同的多学科观点，包括患者/家属 的观点，具有很大的潜力，以改变研究范式和加强创新。通过靶向 该网络的最终目标是改善所有老年人的医疗保健和生活质量。

Delirium, an acute disorder of attention and cognition, is a common, life-threatening, and potentially preventable clinical syndrome in older persons. Given its adverse impact on functioning and quality of life, delirium holds tremendous healthcare and societal implications for the individual, family, community, and healthcare systems. Despite its importance, fundamental advances in diagnosis, pathophysiology, and treatment have been lagging and there is a compelling need for more effective approaches to advance the field. Responding to RFA-AG-16-009, we propose the development of a collaborative research network, NIDUS (Network for Investigation of Delirium across the U.S.), to advance scientific discovery through a purposeful, coordinated effort. Our specific aims are: (1) To create and maintain a database that will catalog elements and provide an efficient platform to enhance the sharing of data and biospecimens both within and outside the proposed network, facilitating multi-site collaboration, secondary analyses, and pilot studies to catalyze the field; (2) To develop a repository of core measures for delirium identification, diagnosis, and severity, and to harmonize data across all types of delirium studies; (3) To support pilot studies to encourage innovative research, targeted to priority areas (risk factors/prognosis; pathophysiology/biomarkers; diagnostic tools/phenomenology; and clinical interventions); (4) To mentor junior investigators interested in delirium research through training programs, educational resources, and integration into network activities; (5) To disseminate information on research resources, data sharing, training opportunities, and potential collaborations in a timely and effective manner to relevant stakeholders and to the broader scientific community. These synergistic aims will leverage the accumulated research expertise of over 28 delirium leaders (12 coinvestigators/Steering Committee and 16 Scientific Advisory Board members) across 27 institutions (who have committed in-kind support), to create the NIDUS collaborative network. NIDUS will provide a research infrastructure with 2 Resource Cores to provide: (1) a catalog of research resources/ databases and (2) a repository of core delirium measures. These will be augmented with 3 Task Forces providing: (1) pilot grants, (2) mentorship and career development support, and (3) dissemination of information through many approaches (e.g., scientific symposia, annual meetings, and social media). NIDUS will create a unique national resource that will facilitate and catalyze innovation in delirium research through providing core resources and training, targeting priority areas, promoting collaboration across disciplines and institutions, engaging and mentoring junior investigators across fields, and disseminating research findings broadly and effectively. Bringing together diverse multidisciplinary perspectives, including patient/family perspectives, holds great potential to shift research paradigms and enhance innovation. Through targeting delirium, the ultimate goal of the network is to improve healthcare and quality of life for all older persons.