NIDUS II: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research in Delirium

NIDUS II：NIDUS 研究基础设施的高级开发和利用，以推进谵妄的跨学科衰老研究

• 批准号: 10561669
• 负责人: SHARON K. INOUYE
• 金额: $ 80万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10561669
• 关键词: Acute Disease; Address; Aging; Alzheimer' s disease patient; Alzheimer' s disease related dementia; American; Area; Assessment tool; Attention; Award; Biological Markers; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Cognition; Data; Data Analyses; Data Set; Databases; Delirium; Development; Diagnosis; Discipline; Elderly; Ensure; Epidemiology; Event; Functional disorder; Future; Goals; Grant; Healthcare Systems; Human; Impaired cognition; Incidence; Individual; Infrastructure; Institution; Intensive Care; Interdisciplinary Study; Investigation; Knowledge; Life; Link; Long-Term Care; Measurement; Measures; Mental Depression; Mentorship; Meta-Analysis; Metadata; Methods; National Institute on Aging; Outcome; Palliative Care; Paper; Participant; Pathway interactions; Patients; Pilot Projects; Prevention program; Principal Investigator; Public Health; Quality of Care; R24; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Risk Factors; Science; Scientific Advances and Accomplishments; Scientist; Severities; Training; acute care; biomarker validation; career development; clinical epidemiology; cost; data resource; design; effective therapy; epidemiology study; frailty; functional decline; improved outcome; innovation; interdisciplinary collaboration; interest; meetings; multiple chronic conditions; novel; outreach; predict clinical outcome; prognostic; response; secondary analysis; support network; targeted therapy trials; therapeutic target; therapy development; treatment strategy; treatment trial; webinar; working group

Delirium, an acute disorder of attention and cognition, is a common, life-threatening, and costly condition for older adults with strong links to Alzheimer’s Disease and Related Dementias (ADRD). In 2015, responding to RFA-AG-16-009, we created the Network for Investigation of Delirium: Unifying Scientists (NIDUS I, R24AG054259), a collaborative interdisciplinary network of 28 investigators spanning 27 institutions which has provided research resources, meetings, pilot grants, and intensive mentorship for >90 trainees, leading to >340 first author papers and >46 grants as principal investigator. Despite this progress, a major knowledge gap in the field remains: safe and effective treatments for delirium. Thus, in response to PAR-20-071, we propose to expand the existing infrastructure as NIDUS II to advance the fundamental science needed to develop more effective treatments for delirium, and ultimately, improve outcomes for delirium in all older adults and in those with ADRD. Our specific aims are: (1) Harmonization Core. To develop and expand innovative measurement methods related to harmonization of delirium measures, outcomes, and predictors for clinical studies and treatment trials, and to refine measures of delirium diagnosis and severity in patients with all stages of ADRD. These approaches will allow us to combine data from multiple existing delirium studies; (2) Research Resources Core. To develop and expand the NIDUS Research Hub to create a collaborative infrastructure that will seed future interdisciplinary studies to advance delirium research (e.g., biomarker studies, intervention development studies); (3) Pilot/Exploratory Studies Core. To award pilot and exploratory grants that will promote collaborative interdisciplinary studies designed to utilize our infrastructure and advance research needed to develop better treatments for delirium. For this aim, we will assemble collaborative working groups (WG) which will address 4 scientific priority areas: (a) Measurement: Harmonize and refine measurement of delirium and related outcomes, including patients with ADRD, and to ensure accurate and sensitive measures for treatment trials; (b) Pathophysiology: Biomarker and mechanistic studies to advance our understanding and identify potential therapeutic targets for treatment trials; (c) Clinical Trials: Intervention development for new multicomponent treatment approaches; (d) Inter-Relationship of Delirium and ADRD: Epidemiologic, risk factor, pathophysiologic, prognostic, and especially treatment studies; (4) Career Development and Outreach Core: for early-stage investigators who will utilize the NIDUS II infrastructure and will be involved in working groups, pilot studies, and training events. Every aspect of NIDUS II is designed to seed innovative scientific discovery, and drive delirium research in a critically important direction: development of effective treatments for delirium, including delirium in ADRD. While we are building on the previous network, the innovation of the new NIDUS II network is the purposeful application and expansion of the infrastructure to advance scientific exploration and impact in specific priority areas of greatest benefit to older Americans. .

妄想是一种注意力和认知的急性疾病，是一种常见，威胁生命且昂贵的状况 与阿尔茨海默氏病和相关痴呆症（ADRD）有密切联系的老年人。 2015年回应 RFA-AG-16-009，我们创建了调查ir妄的网络：统一科学家（Nidus I， R24AG054259），一个合作的跨学科网络，由28个调查人员组成，涉及27个机构 为90名学员提供了研究资源，会议，试点赠款和密集的精神职位，导致> 340 第一作者论文和> 46个赠款作为首席研究员。尽管取得了这种进步，但有重大的知识差距 该领域仍然存在：del妄的安全有效治疗。这是对Par-20-071的回应，我们建议 扩展现有的基础设施作为Nidus II，以推动发展更多的基础科学 在所有老年人中，有效的del妄的有效治疗，最终会改善del妄的预后 与Adrd。我们的具体目的是：（1）协调核心。开发和扩展创新的测量 临床研究和 治疗试验，并完善对ADRD各个阶段的患者的del妄诊断和严重程度的测量。 这些方法将使我们能够结合来自多个现有ir妄研究的数据； （2）研究 资源核心。开发和扩展Nidus Research Hub以创建协作基础架构 这将播种未来的跨学科研究以推进ir妄研究（例如，生物标志物研究，干预 发展研究）； （3）试验/探索性研究核心。授予飞行员和探索性赠款 促进旨在利用我们的基础架构并提高研究的协作跨学科研究 需要为del妄开发更好的治疗方法。为此，我们将组装协作工作组 （WG）将解决4个科学优先级领域：（a）测量： del妄及相关结果，包括ADRD患者，并确保准确和敏感的测量结果 用于治疗试验； （b）病理生理学：生物标志物和机械研究，以提高我们的理解和 确定治疗试验的潜在治疗靶标； （c）临床试验：新的干预开发 多组分治疗方法； （d）del妄与ADRD的关系：流行病学，风险因素， 病理生理，预后，尤其是治疗研究； （4）职业发展和外展核心： 对于将利用Nidus II基础设施并将参与工作组的早期调查人员， 试点研究和培训活动。 Nidus II的各个方面旨在播种创新的科学发现， 并朝着至关重要的方向推动ir妄研究：开发有效的del妄的治疗方法， 包括Adrd的ir妄。当我们在以前的网络上构建时，新的Nidus II的创新 网络是基础架构的有目的应用和扩展，以提高科学探索和 对年长美国人的特定优先领域的影响。 。