Network for Investigation of Delirium across the U.S. (NIDUS)

精神错乱是一种注意力和认知的急性障碍，是一种常见的、危及生命的、潜在的 老年人中可预防的临床综合征。鉴于其对功能和生活质量的不利影响， 精神错乱对个人、家庭、社区和 医疗保健系统。尽管它很重要，但诊断、病理生理学和 治疗一直滞后，迫切需要更有效的方法来推动 菲尔德。响应RFA-AG-16-009，我们建议开发一个协作研究网络， NIDUS(全美妄想症调查网络)，通过 有目的的、协调一致的努力。我们的具体目标是：(1)创建和维护一个将编目的数据库 并提供了一个有效的平台，以加强数据和生物谱的共享 在提议的网络之外，促进多站点协作、二次分析和试点研究，以 促进这一领域；(2)开发用于鉴定、诊断和治疗精神错乱的核心措施储存库 严重性，并协调所有类型的精神错乱研究的数据；(3)支持试点研究，以鼓励 创新研究，针对优先领域(风险因素/预后；病理生理学/生物标记物；诊断 工具/现象学；和临床干预)；(4)指导对精神错乱感兴趣的初级调查人员 通过培训计划、教育资源和融入网络活动进行研究；(5) 传播有关研究资源、数据共享、培训机会和潜力的信息 以及时和有效的方式向相关利益攸关方和更广泛的科学界提供协作 社区。这些协同目标将利用超过28种精神错乱积累的研究专业知识。 领导人员(12名协查人员/指导委员会和16名科学咨询委员会成员)，涉及27 各机构(已承诺提供实物支持)，以创建联合国开发计划署协作网络。死神遗嘱 提供具有2个资源核心的研究基础设施，以提供：(1)研究资源目录/ 数据库和(2)核心精神错乱测量的储存库。这些将增加3个特别工作组 提供：(1)试点赠款；(2)辅导和职业发展支助；(3)宣传 通过许多方式(例如，科学研讨会、年度会议和社交媒体)提供信息。坏死灶 将创建一个独特的国家资源，通过以下方式促进和催化精神错乱研究的创新 提供核心资源和培训，针对优先领域，促进跨学科和 各机构、各领域初级调查人员的参与和指导，以及传播研究成果 广泛而有效地。汇集不同的多学科观点，包括患者/家属 在转变研究范式和加强创新方面具有巨大的潜力。通过目标定位 在精神错乱中，该网络的最终目标是改善所有老年人的医疗保健和生活质量。

Delirium, an acute disorder of attention and cognition, is a common, life-threatening, and potentially preventable clinical syndrome in older persons. Given its adverse impact on functioning and quality of life, delirium holds tremendous healthcare and societal implications for the individual, family, community, and healthcare systems. Despite its importance, fundamental advances in diagnosis, pathophysiology, and treatment have been lagging and there is a compelling need for more effective approaches to advance the field. Responding to RFA-AG-16-009, we propose the development of a collaborative research network, NIDUS (Network for Investigation of Delirium across the U.S.), to advance scientific discovery through a purposeful, coordinated effort. Our specific aims are: (1) To create and maintain a database that will catalog elements and provide an efficient platform to enhance the sharing of data and biospecimens both within and outside the proposed network, facilitating multi-site collaboration, secondary analyses, and pilot studies to catalyze the field; (2) To develop a repository of core measures for delirium identification, diagnosis, and severity, and to harmonize data across all types of delirium studies; (3) To support pilot studies to encourage innovative research, targeted to priority areas (risk factors/prognosis; pathophysiology/biomarkers; diagnostic tools/phenomenology; and clinical interventions); (4) To mentor junior investigators interested in delirium research through training programs, educational resources, and integration into network activities; (5) To disseminate information on research resources, data sharing, training opportunities, and potential collaborations in a timely and effective manner to relevant stakeholders and to the broader scientific community. These synergistic aims will leverage the accumulated research expertise of over 28 delirium leaders (12 coinvestigators/Steering Committee and 16 Scientific Advisory Board members) across 27 institutions (who have committed in-kind support), to create the NIDUS collaborative network. NIDUS will provide a research infrastructure with 2 Resource Cores to provide: (1) a catalog of research resources/ databases and (2) a repository of core delirium measures. These will be augmented with 3 Task Forces providing: (1) pilot grants, (2) mentorship and career development support, and (3) dissemination of information through many approaches (e.g., scientific symposia, annual meetings, and social media). NIDUS will create a unique national resource that will facilitate and catalyze innovation in delirium research through providing core resources and training, targeting priority areas, promoting collaboration across disciplines and institutions, engaging and mentoring junior investigators across fields, and disseminating research findings broadly and effectively. Bringing together diverse multidisciplinary perspectives, including patient/family perspectives, holds great potential to shift research paradigms and enhance innovation. Through targeting delirium, the ultimate goal of the network is to improve healthcare and quality of life for all older persons.