Social Isolation and Loneliness due to COVID-19: Effect on Cognitive, Physical, and Mental Health in Older Adults in the SAGES Study

COVID-19 造成的社会孤立和孤独感：SAGES 研究中对老年人认知、身体和心理健康的影响

• 批准号: 10199108
• 负责人: SHARON K. INOUYE
• 金额: $ 52.07万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10199108
• 关键词: 2019-nCoV; 5 year old; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Anxiety; COVID-19; COVID-19 pandemic; Cessation of life; Clinical; Cognitive; Communities; Complex; Data; Data Collection; Databases; Delirium; Dementia; Disease; Distress; Elderly; Emotions; Exercise; Feeling; Follow-Up Studies; Funding; Grant; Health; Home Care Services; Hospitalization; Impaired cognition; Impairment; Individual; Infection; Interview; Lead; Loneliness; Measures; Medical; Mental Depression; Mental Health; Neuropsychological Tests; Neuropsychology; Nursing Homes; Operative Surgical Procedures; Outcome; Participant; Personal Satisfaction; Persons; Pharmaceutical Preparations; Physical Function; Physical activity; Population; Prevalence; Procedures; Prospective cohort study; Reporting; Resources; Risk; Risk Marker; Safety; Shelter facility; Sleeplessness; Social Distance; Social Network; Social isolation; Socialization; Source; Stress; Structure; Technology; Telephone; Telephone Interviews; Time; United States; Validation; Videoconferences; Videoconferencing; Virus; Visit; Vulnerable Populations; Woman; adverse outcome; cognitive function; cognitive performance; cognitive testing; cohort; coronavirus disease; design; falls; fight against; follow-up; indexing; instrumental activity of daily living; mild cognitive impairment; novel; pandemic disease; physical conditioning; public health relevance; social; social relationships; study population; virtual

PROJECT SUMMARY/ABSTRACT With the arrival of the SARS-CoV-2 virus and associated Coronavirus Disease 19 (COVID-19) to the U.S. in March 2020 came an extraordinary shift in daily living. Social distancing (SD) and sheltering in place (SIP), while essential in the fight against COVID-19, have created unique challenges for the health and well-being of older adults, and in particular those with mild cognitive impairment (MCI) and Alzheimer’s disease and related dementia (ADRD). Decreased socialization for many community-dwelling older adults has led to increased feelings of isolation and loneliness, both of which has been shown in numerous studies to lead to adverse outcomes. For this supplement application, “Social Isolation and Loneliness due to COVID-19: Effect on Cognitive, Physical, and Mental Health in Older Adults in the SAGES Study, we propose two related sub- projects: Sub-Project 1 will examine the effects of COVID-19 related loneliness on cognitive, physical, and mental health in the Successful Aging After Elective Surgery (SAGES I) Study (NIA grant P01 AG031720, PI Inouye), an ongoing prospective cohort study of 315 older adults with an average age of 84 years old, who have been followed after elective major non-cardiac surgery with serial cognitive, physical and functional measures. We will use this well-characterized cohort to (1) Examine potential predictors of loneliness resulting from social distancing, (2) Examine the effect of loneliness on cognitive function in persons with and without MCI or ADRD, and (3) Examine the effect of loneliness on physical and mental health in persons with and without MCI or ADRD. We hypothesize that the SIP order due to the SARS-CoV-2 pandemic will increase loneliness in older adults, and for those with pre-existing MCI and ADRD, loneliness will be associated with greater declines in cognitive, physical and mental health compared to those without MCI and ADRD. In addition to their established annual visit, all SAGES follow-up participants will undergo extra telephone interviews for this project, two at the start of the study and two 6 months later. The interview will include measures of loneliness, social network size, social and physical activities, technology use, pre-existing cognitive and functional or mobility impairment, cognition, anxiety, depression, and COVID-19 infection or exposure. Hospitalizations, medical visits, falls, nursing home placement, new prescription medication use, and death will be determined. Sub-Project 2 will allow us to convert study procedures to remote assessments during the time of COVID-19; and to harmonize and validate the SAGES neuropsychological assessment administered via telephone, videoconferencing, and in-person modes. This study will generate statistically comparable scores across our approaches to examine cognitive trajectories over time. Significance: This study will allow us to evaluate the effect of COVID-19 related loneliness on cognitive, physical, and mental health in older adults and in those with MCI or ADRD. Moreover, this study will allow us to adapt our study procedures to remote during COVID-19 and to cross-validate our remote assessment with phone and in-person modes.

项目总结/文摘