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Conduct of studies to evaluate the toxicity of trimethylsilyldiazomethane in laboratory animals for the National Toxicology Program (NTP)

Conduct of studies to evaluate the toxicity of trimethylsilyldiazomethane in laboratory animals for the National Toxicology Program (NTP)
为国家毒理学计划 (NTP) 开展研究，评估三甲基硅基重氮甲烷对实验动物的毒性
批准号：
9471289
负责人：
BARNEY SPARROW
金额：
$13.08万
依托单位：
BATTELLE MEMORIAL INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-04-15 至 2018-04-14
来源：
https://reporter.nih.gov/project-details/9471289
关键词：
AcuteAnimalsBreathingChemicalsDiazomethaneGoalsHumanLaboratoriesLaboratory AnimalsLungNational Toxicology ProgramPathology ReportPulmonary EdemaRiskSynthesis ChemistryToxic effectToxicity Testsacute toxicityhazard

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中文摘要
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英文摘要
The goal of this project is to characterize the acute toxicity of trimethylsilyldiazomethane (TMSD). TMSD is a methylating agent used in synthetic chemistry. It is marketed as a safe replacement for diazomethane, primarily due to a lower explosive potential. However, two chemists died of acute pulmonary edema while working with TMSD in the laboratory. NTP is performing toxicity studies in order to further examine the potential for TMSD to induce pulmonary toxicity. Laboratory pathology/reporting are in progress. Keywords: toxicity, inhalation, trimethylsilyldiazomethane
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