Conduct of studies to evaluate the toxicity of trimethylsilyldiazomethane in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估三甲基硅基重氮甲烷对实验动物的毒性

• 批准号: 9471289
• 负责人: BARNEY SPARROW
• 金额: $ 13.08万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2018-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9471289
• 关键词: Acute; Animals; Breathing; Chemicals; Diazomethane; Goals; Human; Laboratories; Laboratory Animals; Lung; National Toxicology Program; Pathology Report; Pulmonary Edema; Risk; Synthesis Chemistry; Toxic effect; Toxicity Tests; acute toxicity; hazard

The goal of this project is to characterize the acute toxicity of trimethylsilyldiazomethane (TMSD). TMSD is a methylating agent used in synthetic chemistry. It is marketed as a safe replacement for diazomethane, primarily due to a lower explosive potential. However, two chemists died of acute pulmonary edema while working with TMSD in the laboratory. NTP is performing toxicity studies in order to further examine the potential for TMSD to induce pulmonary toxicity. Laboratory pathology/reporting are in progress. Keywords: toxicity, inhalation, trimethylsilyldiazomethane

本项目的目的是表征三甲基硅基重氮甲烷（TMSD）的急性毒性。TMSD是一种用于合成化学的甲基化剂。它作为重氮甲烷的安全替代品销售，主要是由于爆炸潜力较低。然而，两名化学家在实验室使用TMSD时死于急性肺水肿。NTP正在进行毒性研究，以进一步检查TMSD诱导肺毒性的可能性。实验室病理学/报告正在进行中。 关键词：毒性，吸入，三甲基硅基重氮甲烷