Animal and Animal Food Diagnostic Sample Analysis in Support of FDA Vet-LIRN Activities and Investigations

机会#PAR-17-141宾夕法尼亚大学-动物和动物食品诊断样品 支持FDA Vet-LIRN活动和调查的分析 项目总结/摘要 宾夕法尼亚州动物诊断实验室系统（PADLS）位于宾夕法尼亚大学， 宾夕法尼亚州的新博尔顿中心校区目前提供全面的兽医诊断服务 在鸟类和哺乳动物病理学，微生物学和毒理学领域。PADLS得到充分认可 由美国兽医实验室诊断师协会（AAVLD）和新博尔顿 中心机构是兽医实验室调查和响应的一级实验室成员 网络（Vet-LIRN）。除了保护动物和英联邦的公民， 宾夕法尼亚州针对动物健康和食品安全的威胁，该实验室也是一个关键的 整个美国东部的区域资源使其非常适合这个Vet-LIRN 项目建议书。 我们的实验室在分析各种样品和基质类型方面经验丰富，包括但不限于 仅限于动物样品、环境样品、害虫、水、动物药品和动物和 人类食物产品和配料，如谷物、肉、鱼和奶。目前的方案将 继续受益于我们实验室的兽医诊断经验、专业知识和基础设施 我们将使用它来完成本项目所描述的工作。除了解决当前的 在发生大规模疫情或威胁事件时需要增加实验室能力， 动物食品或药物相关疾病或其他需要快速增援能力的大规模紧急事件 测试，PADLS新博尔顿中心实验室可以进一步加强兽医LIRN通过 更好地及早发现涉及国家食品安全的新事件的诊断活动 和安全，并促进快速反应，以尽量减少伤害和最好地保护人类和 动物健康 我们的实验室为英联邦提供全面的兽医诊断服务， 通过与联邦、州和地方政府的合作， 组织和利益攸关方。某些分析要求作为正常监测活动的一部分，或 常规尸检，而另一些与过度，意外或其他情况有关 无法解释的动物损失或疾病，可能对动物健康和/或动物造成潜在风险，或 人类食品安全。该实验室完全由AAVLD认证，并遵守其“要求 经认可的兽医医学诊断实验室”，满足与以下方面有关的具体要求： 实验室及其活动的所有方面。AAVLD还要求我们的实验室具有质量 有记录政策、系统、计划和程序的系统。由于不同的性质 我们不断改进和完善我们的分析方法， 以确保其灵敏度和特异性。我们有信心继续支持 Vet-LIRN在这个项目中，由于我们目前的资格和经验，以及证明的历史， 通过基础设施和方法开发赠款成功的Vet-LIRN合作 程序. 1

Opportunity #PAR-17-141 University of Pennsylvania – Animal and Animal Food Diagnostic Sample Analysis in Support of FDA Vet-LIRN Activities and Investigations PROJECT SUMMARY/ABSTRACT The Pennsylvania Animal Diagnostic Laboratory System (PADLS) located at the University of Pennsylvania’s New Bolton Center campus currently offers comprehensive veterinary diagnostic services in the areas of avian and mammalian pathology, microbiology, and toxicology. PADLS is fully accredited by the American Association of Veterinary Laboratory Diagnosticians (AAVLD) and the New Bolton Center facility is a first-tier laboratory member of the Veterinary Laboratory Investigation and Response Network (Vet-LIRN). In addition to safeguarding the animals and citizens of the Commonwealth of Pennsylvania against threats to animal health and food safety, the laboratory also serves as a critical regional resource throughout the Eastern United States making it an excellent fit for this Vet-LIRN project proposal. Our laboratory is experienced in the analysis of a variety of sample and matrix types, including but not limited to animal samples, environmental samples, vermin, water, animal drug products, and animal and human food products and ingredients such as grain, meat, fish, and milk. The current program will continue to benefit from our laboratory’s veterinary diagnostic experience, expertise, and infrastructure that we will use to accomplish the work described for this project. In addition to addressing the current need for added laboratory capacity in the event of a large-scale outbreak or threat incident involving animal food or drug-related illnesses or other large-scale emergency events requiring surge capacity testing, the PADLS New Bolton Center Laboratory can further strengthen the Vet-LIRN through diagnostic activities that better enable early detection of emerging events involving national food safety and security and facilitate the rapid responses that can minimize harm and best protect both human and animal health. Our laboratory provides comprehensive veterinary diagnostic services to the Commonwealth of Pennsylvania and the surrounding region through collaborations with federal, state, and local organizations and stakeholders. Some analyses are requested as part of normal surveillance activities or routine necropsies, while others are associated with cases of excessive, unexpected, or otherwise unexplainable animal losses or illness that may potentially pose a risk to animal health and/or animal or human food safety. The laboratory is fully accredited by AAVLD and adheres to their “Requirements for an Accredited Veterinary Medical Diagnostic Laboratory”, meeting specific requirements pertaining to all aspects of the laboratory and its activities. AAVLD also requires that our laboratory has a Quality System in place that documents policies, systems, programs, and procedures. Due to the varied nature of the sample matrices we receive we are constantly improving and refining our analytical methods in order to ensure their sensitivity and specificity. We are confident in our ability to continue to support Vet-LIRN in this project due to our present qualifications and experience and a proven history of successful Vet-LIRN collaborations through both the infrastructure and method development grant programs. 1