Program 2: Cancer Imaging Program (CIP)

项目 2：癌症影像项目 (CIP)

• 批准号: 9315739
• 负责人: Jennifer Kehlet Barton
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315739
• 关键词: Advanced Development; Animals; Appointment; Arizona; Biological Markers; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Intervention; Cancer Model; Chemicals; Clinic; Clinical; Clinical Trials; Collaborations; Contrast Media; Critiques; Cyclotrons; Data; Development; Diagnosis; Diagnostic Procedure; Diagnostic radiologic examination; Doctor of Philosophy; Environment; Fatty acid glycerol esters; Fostering; Foundations; Funding; Future; Gamma Rays; Glioblastoma; Goals; Grant; Health; Healthcare Systems; Hypoxia; Image; Imaging Device; Imaging technology; Intervention Studies; Joints; Laboratories; Lead; Leadership; Magnetic Resonance Imaging; Malignant Neoplasms; Mammographic Density; Manuscripts; Mentors; Methodology; Mission; Modeling; Monitor; Ovarian Carcinoma; Patients; Peer Review; Performance; Positron-Emission Tomography; Prevention; Process; Published Comment; Radial; Radiochemistry; Research; Research Personnel; Resources; Risk; Science; Screening for cancer; Secure; Source; Technology; Testing; Training; Training Programs; Translating; Translations; Ultrasonography; Universities; Validation; Water; base; bioimaging; cancer diagnosis; cancer imaging; cancer prevention; cancer therapy; clinical application; clinical development; clinical research site; college; cost; design; image processing; imaging modality; imaging program; imaging system; innovation; liver tumor ablation; mathematical model; member; molecular imaging; nanoDroplet; new technology; novel; novel diagnostics; novel strategies; nuclear imaging; optical imaging; preclinical trial; prevent; programs; prototype; skills; spectroscopic imaging; tissue oxygenation; translational pipeline; tumor

Project Summary / Abstract: Cancer Imaging Program (CIP) The scientific goal of the Cancer Imaging Program (CIP) is to develop and apply imaging technologies and imaging methods for cancer prevention and intervention studies. Members of the CIP are working at the forefront of the field and have been eminently successful in utilizing the theoretical underpinnings of imaging science to advance new imaging technologies for a wide array of critical cancer applications. Program activities are organized under three major themes: Theme 1) Advancement of major biomedical imaging technologies for cancer; Theme 2) Molecular imaging and the development of advanced contrast agents, including analysis of their mechanisms; and Theme 3) Advancement of theoretical image science related to cancer. The CIP provides a dynamic cancer-focused environment that fosters inter-programmatic collaborations with a robust translational pipeline that facilitates entry of research applications into investigator-initiated clinical trials (IITs). CIP has two Specific Aims: Aim 1) To promote advances in imaging science and technology and their application in the context of cancer biology, early cancer detection, development and monitoring of cancer therapies, and cancer prevention studies; Aim 2) To promote translation of the science into clinical trials and development and testing of new technologies in the clinic through investigator-initiated clinical trials (IITs) and coordinated validation at other clinical sites. CIP leadership, in cooperation with the UACC and University of Arizona (UA) leadership, is instrumental in securing sources for pilot funding for prototype testing/development and in providing access to unique laboratory and clinical methodologies to aid researchers who are involved in the discovery and development of new diagnostic methods and new anticancer therapies. The CIP builds on the UA's excellence in imaging science. The CIP has 31 Members, from 10 different departments, with complementary, specialized skills drawn from multiple colleges and departments across the UA. Joint appointments in multiple departments and membership in Graduate Interdisciplinary Programs provide the dynamic networks of interaction required for highly innovative research. The effective integration of the diverse Membership into cancer imaging research, combined with funded mentoring and training programs, have resulted in the sustained, broad-based development of novel approaches to cancer diagnosis/therapy and significant high-impact contributions. CIP Members have contributed to 249 cancer-relevant manuscripts, of which 33% were intra-programmatic and 31% were inter-programmatic. As of September 1, 2015, the CIP Program secured more than $7.5M in total annual grant dollars, with $3M of that from the NCI and $4M in other peer-reviewed funding. Major funding held by Program Members includes a Center Grant (P41EB002035) that supports UA's “Center for Gamma Ray Imaging” and a Training grant (T32EB000809) entitled “Biomedical Imaging and Spectroscopy.”

项目摘要/摘要：肿瘤影像计划(CIP) 癌症成像计划(CIP)的科学目标是开发和应用成像技术和 癌症预防和干预研究的成像方法。CIP的成员正在 处于该领域的前沿，并在利用成像的理论基础方面取得了显著的成功 科学推动新的成像技术，用于广泛的关键癌症应用。计划活动 在三大主题下组织：主题1)主要生物医学成像技术的进步 癌症；主题2)分子成像和先进造影剂的发展，包括分析 其机制；以及主题3)与癌症相关的理论影像科学的进展。CIP 提供以癌症为重点的动态环境，通过强大的 促进研究申请进入研究人员发起的临床试验(IITs)的翻译管道。 CIP有两个具体目标：目标1)促进成像科学和技术的进步及其 在癌症生物学、癌症早期检测、癌症发展和监测方面的应用 治疗和癌症预防研究；目的2)促进将科学转化为临床试验和 通过研究人员发起的临床试验(IITs)和 在其他临床站点进行协调验证。CIP领导层，与UACC和华盛顿大学合作 亚利桑那州(UA)领导层，在确保原型测试/开发的试点资金来源方面发挥了重要作用 并提供独特的实验室和临床方法来帮助参与研究的研究人员 新的诊断方法和新的抗癌疗法的发现和发展。CIP建立在 UA在成像科学方面的卓越表现。CIP有31名成员，来自10个不同的部门， 来自亚利桑那州多所学院和院系的互补专业技能。接合 在多个部门的任命和研究生跨学科计划的成员资格提供 高度创新的研究需要动态的互动网络。多元文化的有效融合 加入癌症成像研究，再加上资助的指导和培训计划，已经 导致癌症诊断/治疗新方法的持续、广泛的发展和 重大的高影响力贡献。CIP成员贡献了249篇与癌症有关的手稿， 其中33%是方案内方案，31%是方案间方案。自2015年9月1日起，CIP 该计划获得了超过750万美元的年度赠款，其中300万美元来自NCI，400万美元来自NCI 其他经同行审查的资金。计划成员持有的主要资金包括中心赠款 (P41EB002035)，支持UA的“伽马射线成像中心”和培训补助金(T32EB000809) 题为“生物医学成像和光谱”。