Program 2: Cancer Imaging Program (CIP)

项目 2：癌症影像项目 (CIP)

• 批准号: 9315739
• 负责人: Jennifer Kehlet Barton
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315739
• 关键词: Advanced Development; Animals; Appointment; Arizona; Biological Markers; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Intervention; Cancer Model; Chemicals; Clinic; Clinical; Clinical Trials; Collaborations; Contrast Media; Critiques; Cyclotrons; Data; Development; Diagnosis; Diagnostic Procedure; Diagnostic radiologic examination; Doctor of Philosophy; Environment; Fatty acid glycerol esters; Fostering; Foundations; Funding; Future; Gamma Rays; Glioblastoma; Goals; Grant; Health; Healthcare Systems; Hypoxia; Image; Imaging Device; Imaging technology; Intervention Studies; Joints; Laboratories; Lead; Leadership; Magnetic Resonance Imaging; Malignant Neoplasms; Mammographic Density; Manuscripts; Mentors; Methodology; Mission; Modeling; Monitor; Ovarian Carcinoma; Patients; Peer Review; Performance; Positron-Emission Tomography; Prevention; Process; Published Comment; Radial; Radiochemistry; Research; Research Personnel; Resources; Risk; Science; Screening for cancer; Secure; Source; Technology; Testing; Training; Training Programs; Translating; Translations; Ultrasonography; Universities; Validation; Water; base; bioimaging; cancer diagnosis; cancer imaging; cancer prevention; cancer therapy; clinical application; clinical development; clinical research site; college; cost; design; image processing; imaging modality; imaging program; imaging system; innovation; liver tumor ablation; mathematical model; member; molecular imaging; nanoDroplet; new technology; novel; novel diagnostics; novel strategies; nuclear imaging; optical imaging; preclinical trial; prevent; programs; prototype; skills; spectroscopic imaging; tissue oxygenation; translational pipeline; tumor

Project Summary / Abstract: Cancer Imaging Program (CIP) The scientific goal of the Cancer Imaging Program (CIP) is to develop and apply imaging technologies and imaging methods for cancer prevention and intervention studies. Members of the CIP are working at the forefront of the field and have been eminently successful in utilizing the theoretical underpinnings of imaging science to advance new imaging technologies for a wide array of critical cancer applications. Program activities are organized under three major themes: Theme 1) Advancement of major biomedical imaging technologies for cancer; Theme 2) Molecular imaging and the development of advanced contrast agents, including analysis of their mechanisms; and Theme 3) Advancement of theoretical image science related to cancer. The CIP provides a dynamic cancer-focused environment that fosters inter-programmatic collaborations with a robust translational pipeline that facilitates entry of research applications into investigator-initiated clinical trials (IITs). CIP has two Specific Aims: Aim 1) To promote advances in imaging science and technology and their application in the context of cancer biology, early cancer detection, development and monitoring of cancer therapies, and cancer prevention studies; Aim 2) To promote translation of the science into clinical trials and development and testing of new technologies in the clinic through investigator-initiated clinical trials (IITs) and coordinated validation at other clinical sites. CIP leadership, in cooperation with the UACC and University of Arizona (UA) leadership, is instrumental in securing sources for pilot funding for prototype testing/development and in providing access to unique laboratory and clinical methodologies to aid researchers who are involved in the discovery and development of new diagnostic methods and new anticancer therapies. The CIP builds on the UA's excellence in imaging science. The CIP has 31 Members, from 10 different departments, with complementary, specialized skills drawn from multiple colleges and departments across the UA. Joint appointments in multiple departments and membership in Graduate Interdisciplinary Programs provide the dynamic networks of interaction required for highly innovative research. The effective integration of the diverse Membership into cancer imaging research, combined with funded mentoring and training programs, have resulted in the sustained, broad-based development of novel approaches to cancer diagnosis/therapy and significant high-impact contributions. CIP Members have contributed to 249 cancer-relevant manuscripts, of which 33% were intra-programmatic and 31% were inter-programmatic. As of September 1, 2015, the CIP Program secured more than $7.5M in total annual grant dollars, with $3M of that from the NCI and $4M in other peer-reviewed funding. Major funding held by Program Members includes a Center Grant (P41EB002035) that supports UA's “Center for Gamma Ray Imaging” and a Training grant (T32EB000809) entitled “Biomedical Imaging and Spectroscopy.”

项目摘要/摘要：癌症成像计划 (CIP) 癌症成像计划（CIP）的科学目标是开发和应用成像技术， 用于癌症预防和干预研究的成像方法。 CIP 的成员正在以下机构工作： 处于该领域的前沿，并在利用成像的理论基础方面取得了巨大成功 科学来推进新成像技术的广泛关键癌症应用。节目活动 分为三大主题： 主题 1) 主要生物医学成像技术的进步 对于癌症；主题2）分子成像和先进造影剂的开发，包括分析 他们的机制；主题3）与癌症相关的理论图像科学的进展。投资移民计划 提供一个以癌症为中心的动态环境，促进项目间的合作 促进研究应用进入研究者发起的临床试验（IIT）的转化管道。 CIP 有两个具体目标： 目标 1) 促进成像科学技术及其应用的进步 在癌症生物学、早期癌症检测、癌症发展和监测方面的应用 治疗和癌症预防研究；目标 2) 促进科学转化为临床试验 通过研究者发起的临床试验（IIT）在临床中开发和测试新技术 其他临床中心的协调验证。 CIP 领导，与 UACC 和大学合作 亚利桑那州 (UA) 的领导地位有助于确保原型测试/开发的试点资金来源 并提供独特的实验室和临床方法来帮助参与研究的研究人员 新诊断方法和新抗癌疗法的发现和开发。 CIP 建立在 UA 在影像科学领域的卓越表现。 CIP 有 31 名成员，来自 10 个不同的部门， 来自 UA 多个学院和院系的互补专业技能。联合的 多个部门的任命和研究生跨学科项目的成员资格提供了 高度创新的研究需要动态的互动网络。多元化的有效整合 癌症成像研究的会员资格，加上资助的指导和培训计划，已经 导致了癌症诊断/治疗新方法的持续、广泛发展 具有重大影响力的贡献。 CIP 成员贡献了 249 篇与癌症相关的手稿，其中 其中 33% 是项目内的，31% 是项目间的。自2015年9月1日起，CIP 该计划获得了超过 750 万美元的年度拨款总额，其中 300 万美元来自 NCI，400 万美元来自 其他经过同行评审的资金。计划成员持有的主要资金包括中心补助金 (P41EB002035)，支持 UA 的“伽马射线成像中心”和培训补助金 (T32EB000809) 题为“生物医学成像和光谱学”。