Pre-doctoral Training Program in Integrative Vascular Biology

综合血管生物学博士前培训项目

• 批准号: 9210167
• 负责人: Christopher P. Mack
• 金额: $ 41.85万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9210167
• 关键词: Biology; Blood Vessels; Training Programs; pre-doctoral

Program Abstract The complexity of cardiovascular disease has hindered our understanding of its deveopment and progression. To uncover the uncover the mechanisms by which genetic variation and environmental factors influence cardiovascular development and disease, the next generation of scientists will need to be trained to use a variety of approaches, technologies and model systems. In response to this demand the Integrative Vascular Biology (IVB) Pre-doctoral Training Program was established at UNC in 2002 to promote a collaborative interdisciplinary training environment for pre-doctoral students in the cardiovascular field. The IVB Program combines the breadth and depth of the cardiovascular research faculty with other research strengths at UNC in genetic model systems, state-of-the-art cell biology and imaging, high throughput genomic and proteomic analyses, and computational biology. The overall goal of the IVB Program is to provide Trainees with the interdisciplinary and collaborative skills necessary to extend their thesis work into new, innovative, and productive directions. Specific Aim 1 is to connect Trainees in broad areas of cardiovascular research by requiring them to collaborate with secondary mentors outside of their field. This training mechanism was specifically designed to “connect” graduate students in broad areas of cardiovascular biology and cardiovascular health research. The program teaches students to apply molecular, cellular, genetic, and computational approaches to pathological and physiological questions in cell, organ, and whole animal systems; to merge hypothesis- and discovery-based research; and to develop high-throughput approaches for use in complex models. Specific Aim 2 is to provide Trainees with a broad understanding of cardiovascular development and disease. This will be achieved through advanced paper-based cardiovascular courses, cardiovascular seminars by leaders in the field, and through bi-weekly student-led discussion groups. Specific Aim 3 is to enhance the skills necessary for effective collaboration and career advancement. Trainees will improve their communication skills by presenting their work at formal and informal IVB events and students will attend IVB Workshops on grant writing, career development, and scientific rigor and responsibility. The IVB Program is administered by UNC McAllister Heart Institute and is directed by Dr. Christopher Mack (Associate Professor of Pathology) a respected vascular biologist who has been heavily involved in graduate student training at multiple levels.. He is assisted by Co-directors Nobuyo Maeda (Professor of Pathology) and Vicki Bautch (Professor of Biology) and by the advice of executive and advisory committeees made up of well- established senior vascular biologist. A major strength of the Program is the breadth and diversity of the 39 primary training faculty who are committed to graduate student training and who are using cutting edge approaches to answer a wide variety of cardiovascular questions. In summary, with an outstanding history in cardiovascular biology research, a strong group of investigators centered around the MHI, a well-developed academic program in Cardiovascular Science, a large pool of well-qualified applicants, and research excellence in genetic model systems, cell biology, and computational biology, the UNC Integrative Vascular Biology Program offers an outstanding environment for multidisciplinary training of pre-doctoral students.

程序摘要 心血管疾病的复杂性阻碍了我们对其发展和进展的了解。 揭示遗传变异和环境因素影响的机制 心血管发展和疾病，下一代科学家将需要接受培训，使用 各种方法、技术和模型系统。为回应这一需求，一体化血管 生物学(IVB)博士前培训计划于2002年在北卡罗来纳大学设立，旨在促进 心血管领域博士前学生的跨学科培训环境。IVB项目 将心血管研究人员的广度和深度与北卡罗来纳大学的其他研究优势结合在一起 遗传模型系统，最新的细胞生物学和成像，高通量基因组和蛋白质组 分析和计算生物学。IVB计划的总体目标是为学员提供 跨学科和协作能力，将他们的论文工作扩展到新的、创新的 和富有成效的方向。具体目标1是将心血管研究广泛领域的受训人员联系起来 通过要求他们与自己领域外的二级导师合作。这一培训机制是 专门设计用来连接心血管生物学和心血管医学领域的研究生 心血管健康研究。该项目教授学生应用分子、细胞、遗传和 细胞、器官和整个动物病理和生理问题的计算方法 系统；合并基于假设和发现的研究；并开发高通量方法 在复杂模型中使用。具体目标2是为学员提供对心血管疾病的广泛了解 发展和疾病。这将通过高级纸质心血管课程来实现， 由该领域的领导者举办的心血管研讨会，以及每两周一次的学生主导的讨论小组。特定的 目标3是提高有效协作和职业发展所需的技能。实习生将 通过在正式和非正式的IVB活动中展示他们的工作来提高他们的沟通技能，学生将 参加IVB关于基金撰写、职业发展、科学严谨性和责任感的研讨会。IVB 该计划由北卡罗来纳大学麦卡利斯特心脏研究所管理，由Christopher Mack博士(助理 病理学教授)一位受人尊敬的血管生物学家，一直积极参与研究生的研究 多层次的培训..他得到了联合董事前田信洋(病理学教授)和Vicki的协助 Bautch(生物学教授)和执行和咨询委员会的建议，这些委员会由Well- 资深血管生物学家。该计划的一个主要优势是39个国家的广度和多样性 致力于研究生培养并使用尖端技术的初级培训教师 回答各种各样的心血管问题的方法。总而言之，拥有杰出的历史 心血管生物学研究方面，一批强大的研究人员围绕着三菱重工，一个发达的 心血管科学的学术计划，一大批合格的申请者，以及研究 在遗传模型系统、细胞生物学和计算生物学方面的卓越表现，北卡罗来纳大学综合血管 生物专业为博士生的多学科培养提供了良好的环境。