Systems Biology: A Foundation for Interdisciplinary Careers

系统生物学：跨学科职业的基础

• 批准号: 9750117
• 负责人: German Andres Enciso
• 金额: $ 29.99万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750117
• 关键词: Area; Biological Sciences; Biology; Biomedical Research; Collaborations; Communication; Complex; Data Analyses; Data Set; Educational process of instructing; Educational workshop; Engineering; Exercise; Faculty; Fellowship; Female; Financial Support; Fostering; Foundations; Gene Expression Regulation; Generations; Goals; Growth; Individual; Information Dissemination; Infrastructure; Instruction; Interdisciplinary Study; Knowledge; Laboratories; Light; Logistics; Mathematics; Mentors; Methodology; Methods; Minority; Modeling; Modernization; Molecular; Morphogenesis; National Institute of General Medical Sciences; Nature; Output; Participant; Pattern Formation; Physics; Postdoctoral Fellow; Preparation; Professional Competence; Research; Research Activity; Research Personnel; Scientist; Signal Transduction; Site; Software Tools; Statistical Models; Students; Systems Biology; Technical Expertise; Testing; Training; Training Activity; Underrepresented Minority; United States National Institutes of Health; Visit; Vocabulary; Woman; Work; biological research; career; career development; cohort; community building; complex biological systems; computer science; data acquisition; design; experience; follow-up; genome-wide analysis; graduate student; imaging properties; innovation; interdisciplinary approach; laboratory experiment; laboratory module; lectures; mathematical model; member; online resource; outreach; programs; receptor; recruit; research and development; skill acquisition; skills; symposium; synthetic biology; theories; tool

We propose a program to enhance the training and career development of scientists who seek to undertake interdisciplinary biological and biomedical research that draws upon ideas and tools from mathematics, physics, engineering and computer science, as embodied by the young field of Systems Biology. The program is centered upon a three-week intensive course at UC Irvine, followed by one to two years of follow-up mentoring and career development activity. The course is intended for graduate students, postdocs and more advanced scientists, both those with backgrounds in experimental biology—who typically need additional preparation in mathematics and computation—and those with backgrounds in mathematics, physics, engineering or computer science—who usually need additional preparation in the foundations of biology. We aim to train around 20 individuals each year. The proposed program begins with a one-week preparatory workshop, followed by a two-week core course in which lectures and laboratory modules will expose participants to cutting-edge interdisciplinary methodologies and research topics. The program will also feature extensive mentoring and career-skill building activities, including panel discussions, presentations, mentored team projects, and individually-guided development of research or fellowship proposals. These activities will involve 27 UCI faculty with research and teaching expertise in mathematics, physics, computer science, engineering and the biological sciences. Outreach activities include dissemination of information through online resources and a systems biology regional conference, as well as participation in workshops at interdisciplinary and minority conferences. The specific goals of the course include (i) conveying an understanding of Systems Biology and its interdisciplinary nature; (ii) filling gaps in technical expertise and vocabulary, and developing a deep understanding of mathematical models; (iii) acquainting participants with the challenges of collaboration and communication in interdisciplinary research, (iv) fostering community building, and (v) enhancing career development. Lecture materials (video-recorded), training datasets, and software tools will be made freely available through on-line distribution to maximize outreach. Course administration and logistics will be handled by the UC Irvine Center for Complex Biological Systems (CCBS), an NIH-designated National Center for Systems Biology.

我们建议一项计划，以增强试图寻求的科学家的培训和职业发展 进行跨学科的生物学和生物医学研究，以借鉴思想和工具 数学，物理，工程和计算机科学，由年轻的系统生物学领域体现。 该计划集中在加州大学欧文分校的三周密集课程上，然后是一到两年 后续的心理和职业发展活动。该课程适用于研究生，博士后 以及更高级的科学家，既有实验生物学背景的人，他们通常都需要 数学和计算中的其他准备工作以及具有数学，物理学背景的人 工程或计算机科学 - 通常需要在生物学基础上进行其他准备。我们 旨在每年训练大约20个人。 拟议的计划始于为期一周的准备工作室，然后是为期两周的核心课程 讲座和实验室模块将使参与者接触到尖端的跨学科 方法和研究主题。该计划还将采用广泛的心理和职业技能建设 活动，包括小组讨论，演讲，修补团队项目和单独指导 研究或奖学金建议的发展。这些活动将涉及27位UCI教师与研究和 数学，物理，计算机科学，工程和生物科学的教学专业知识。 外展活动包括通过在线资源和系统生物学传播信息 区域会议以及跨学科和少数群体会议的研讨会。 该课程的具体目标包括（i）传达对系统生物学及其ITS的理解 跨学科性质； （ii）填补技术专长和词汇的空白，并发展深刻 了解数学模型； （iii）熟悉参与者的协作挑战和 跨学科研究中的沟通，（iv）促进社区建设和（v）增强职业 发展。讲座材料（视频记录），培训数据集和软件工具将自由制作 可通过在线分销中获得最大化的外展。课程管理和物流将被处理 NIH指定的国家中心 系统生物学。