2019 Fibronectin, Integrins and Related Molecules GRC/GRS

摘要 我们请求部分支持“纤连蛋白，整合素和相关分子”戈登研究会议 (GRC)和戈登研究研讨会（GRS），2019年5月4日至10日在文艺复兴时期的托斯卡纳Il Ciocco，意大利。 这些会议将集中在所有最活跃的研究主题领域的新的未发表的研究结果。在 除了既定的特邀演讲者外，拟议的9场会议中的每一场都将有一个或两个演讲， 研究生、博士后研究员或早期职业调查员。这些演讲者将从 提交摘要，以便为讨论最新发现创造机会， 令人兴奋的研究作为口头报告。最后，来自GRS的两位最佳演讲者（与 主要会议）将被选中进行简短的演讲。从历史上看，会议提供了一个独特的论坛， 将一群具有共同兴趣的早期职业和资深科学家聚集在一起， 细胞与细胞外基质相互作用的机制及其与发育和疾病的相关性。 在这次会议期间，建立了合作关系，新的科学家被招募到该领域， 关于细胞-细胞外基质相互作用的发现经常在该会议上首次报道。新 与2019年会议相关的主题包括利用冷冻电子显微镜的结构生物学， 利用生物传感器和单分子技术的现有光学显微镜，粘附信号的空间控制， 细胞-细胞外基质相互作用在代谢和粘附信号疗法中的作用。的最新情况 重要的主题，如张力传感和信号，细胞骨架调节，迁移机制， 发展中的粘附信号模型也包括在内。总的来说，这次国际会议将 展示了细胞-细胞外基质相互作用研究领域的主要进展，并将成为 一直是该领域的开创性会议。

Abstract We request partial support for the “Fibronectin, Integrins and Related Molecules” Gordon Research Conference (GRC) and Gordon Research Seminar (GRS), May 4-10, 2019 at the Renaissance Tuscany Il Ciocco, Italy. These conferences will focus on new unpublished findings in all of the most actively researched topic areas. In addition to the established invited speakers, each of the 9 sessions proposed will feature one or two talks from graduate students, postdoctoral fellows or early career investigators. These speakers will be selected from submitted abstracts in order to create opportunities for discussion of late-breaking discoveries and incorporate exciting research as oral presentations. Finally, two best speakers from the GRS (that is held in conjunction with the main conference) will be selected for a short talk. Historically, the conference has provided a unique forum for bringing together an international group of early career and senior scientists with a common interest in the mechanisms whereby cells interact with the extracellular matrix and its relevance to development and disease. During this conference, collaborations are established, new scientists are recruited to the field, and major discoveries on cell-extracellular matrix interactions are often reported for the first time at this conference. New topics relative to the conference in 2019 include structural biology utilizing cryo-electron microscopy, state-of- the-art light microscopy utilizing biosensors and single molecule techniques, spatial control of adhesion signaling, role of cell-extracellular matrix interactions in metabolism and adhesion signaling therapies. Updates on important topics such as tension sensing and signaling, cytoskeletal regulation, mechanisms of migration, and models of adhesion signaling in development are also included. Overall, this international conference will showcase the major advances in the field of cell-extracellular matrix interactions research and will be, as it has always been, the seminal conference in the field.