Nanoparticle Synthesis and Characterization

纳米粒子的合成和表征

• 批准号: 9751794
• 负责人: Teresa J Porri
• 金额: $ 2.97万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751794
• 关键词: Address; Brain Neoplasms; CCNE1 gene; Cancer Patient; Characteristics; Chemistry; Clinical; Coupled; Detection; Development; Diagnosis; Diagnostic; Drug Kinetics; Dyes; Educational workshop; Encapsulated; Equipment; Fluorescent Dyes; Funding; Gel Chromatography; Generations; Geometry; Goals; Heterogeneity; High Pressure Liquid Chromatography; Human; Hybrids; Label; Lasers; Ligands; Localized Malignant Neoplasm; Lymph Node Mapping; Malignant Neoplasms; Medicine; Memorial Sloan-Kettering Cancer Center; Metastatic Melanoma; Methodology; Modality; Operative Surgical Procedures; Optics; Participant; Particle Size; Peptides; Polyethylene Glycols; Positron-Emission Tomography; Protocols documentation; Radiation therapy; Radioisotopes; Research; Research Project Grants; Resource Sharing; Resources; Silicon Dioxide; Staging; Surface; System; Technology; Therapeutic; Therapeutic Index; Training; Translating; Translations; Vision; Water; Work; absorption; aluminosilicate; base; clinical investigation; experimental study; feeding; imaging properties; improved; instrumentation; light scattering; member; nanomaterials; nanomedicine; nanoparticle; novel; oncology; particle; theranostics; therapeutic nanoparticles; tool

SHARED RESOURCE CORE - NANOPARTICLE SYNTHESIS & CHARACTERIZATION CORE (CORE A) Project Abstract/Summary The vision of MC2TCN is to advance, translate, and disseminate a suite of ultrasmall (<10 nm) silica-organic hybrid nanoparticles for theranostics applications in oncology. In order to support the proposed research to achieve this overarching goal, the Shared Resources Core (SRC) on Nanoparticle Synthesis and Characterization (Core-A) will provide for particle synthesis and characterization investigations of clinical-grade C' dots and C rings with particle sizes below 10 nm. Particular focus of this Core will be to provide instrumentation and expertise in the analysis of heterogeneities in particle size and particle surface chemistry enabling studies in the Center on how these heterogeneities modulate pharmacokinetics (PK), clearance profiles, and target-to-background ratios, a key issue of nanomaterials in medicine but usually challenging to address. This will be accomplished by (1) addition of a high performance liquid chromatography (HPLC) system with particle specific detection equipment for particle separations based on surface chemistry, (2) addition of a gel permeation chromatography (GPC) system for particle separation based on particle size, (3) acquisition of lasers for optical experiments tuned to the absorption characteristics of dyes encapsulated into the various optical nanoparticles. Other equipment needed to synthesize and characterize Center-wide used nanoparticles already exist in the space at Cornell, where the Core will be located, and includes hood space, a glove box, a zeta-sizer, and dynamic light scattering. This core will serve all research projects (RP1-4) of the Center.

共享资源核心 - 纳米粒子合成和表征核心（核心 A） 项目摘要/总结 MC2TCN 的愿景是推进、转化和传播一套超小型（<10 nm）二氧化硅有机材料 用于肿瘤学治疗诊断应用的混合纳米颗粒。为了支持拟议的研究 为了实现这一总体目标，纳米粒子合成共享资源核心（SRC）和 表征（Core-A）将提供临床级的颗粒合成和表征研究 粒径小于 10 nm 的 C' 点和 C 环。该核心的特别重点是提供 颗粒尺寸和颗粒表面化学异质性分析的仪器和专业知识 使中心能够研究这些异质性如何调节药代动力学 (PK)、清除率 轮廓和目标背景比，这是医学中纳米材料的一个关键问题，但通常具有挑战性 地址。这将通过 (1) 添加高效液相色谱 (HPLC) 来实现 具有用于基于表面化学的颗粒分离的颗粒特定检测设备的系统，(2) 添加凝胶渗透色谱 (GPC) 系统，用于根据粒径进行颗粒分离，(3) 采集用于光学实验的激光，调谐到封装在其中的染料的吸收特性 各种光学纳米颗粒。合成和表征中心范围内使用的其他设备 核心所在的康奈尔大学空间中已经存在纳米颗粒，其中包括引擎盖空间、 手套箱、zeta 尺寸测量器和动态光散射。该核心将服务于该中心的所有研究项目（RP1-4） 中心。