Neural dynamics of human working memory networks
人类工作记忆网络的神经动力学
基本信息
- 批准号:9753357
- 负责人:
- 金额:$ 52.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-26 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAffectiveAreaAttention Deficit DisorderAuditory areaBehaviorBehavioralBrainBrain regionClinicalCognitiveColorComputer SimulationDataDementiaDiagnosisDrug AddictionElectrocorticogramElectrophysiology (science)EsthesiaEtiologyExhibitsFunctional Magnetic Resonance ImagingFunctional disorderGoalsHumanImpairmentKnowledgeLateralLesionLinkMaintenanceMediatingMemoryMental disordersMethodsMissionModelingMonkeysMotor PathwaysNatureNeuronsNeurosciencesNeurosciences ResearchOutputPerceptionPerformancePlayPrefrontal CortexPrimatesProcessPublic HealthResearchResearch PersonnelRoleSchizophreniaSensoryShort-Term MemorySignal TransductionStimulusStrokeStructureSubstance AddictionSystemTestingTherapeutic InterventionTimeTranscranial magnetic stimulationTraumatic Brain InjuryTreatment EfficacyUnited States National Institutes of HealthUpdateVisual Cortexbehavior influencecognitive controldistractionexperienceflexibilityfrontal lobefrontal lobe functionhuman subjectinsightmultimodalityneocorticalnervous system disorderneural circuitneuroimagingneuromechanismneurophysiologynonhuman primatenormal agingpreservationprospectiverelating to nervous systemresponsespatiotemporal
项目摘要
PROJECT SUMMARY/ABSTRACT
Intentional and flexible behavior, often called “cognitive control”, requires the maintenance and selection of perceptual, mnemonic, and response representations consistent with the broader context and higher-level goals. One of the most challenging problems in neuroscience is determining how voluntary, goal-directed behavior arises from the distributed activity of billions of neurons in the brain. To tackle this problem, one must understand the cognitive and neural mechanisms of working memory (WM), a fundamental ability underlying goal-directed behavior. The study of WM, however, has only minimally benefited from the revolution in neural dynamics that has been experienced in other fields. Discovery of WM neural dynamics is particularly important given that WM requires the interaction of multiple brain systems, notably the lateral PFC (lPFC) and posterior processing systems. Thus, a determination of the neural mechanisms underlying lPFC function, the most elaborated neocortical region in primates, and WM, remains a fundamental goal of neuroscience research. To achieve this goal, three different methods will be implemented in human subjects in this proposal during the performance of WM task – ECoG, fMRI and TMS. This will provide a convergent approach that tests hypotheses regarding the spatio-temporal basis of WM and will be able to determine the causality of the electrophysiological and neuroimaging findings. Although not the prime focus of the proposal, the ECoG data will also provide a link to monkey neurophysiology and the neural drivers of the fMRI BOLD signal. Basic knowledge about WM and frontal lobe function can provide substantial insights into the nature of a large number of psychiatric and neurological disorders affecting PFC function such as schizophrenia, dementia, stroke and traumatic brain injury; as well as many other conditions such as attention-deficit disorder, substance addiction and normal aging, that are proposed to involve selective dysfunction of frontal brain systems. Moreover, cognitive and behavioral deficits from PFC damage are particularly challenging to treat. A greater understanding of frontal lobe function is necessary for developing effective therapeutic interventions.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARK D'ESPOSITO其他文献
MARK D'ESPOSITO的其他文献
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{{ truncateString('MARK D'ESPOSITO', 18)}}的其他基金
Developing Behavioral and Neuroimaging Predictors of Stroke Recovery
开发中风恢复的行为和神经影像预测因子
- 批准号:
10552568 - 财政年份:2019
- 资助金额:
$ 52.42万 - 项目类别:
Neural dynamics of human working memory networks
人类工作记忆网络的神经动力学
- 批准号:
9357693 - 财政年份:2016
- 资助金额:
$ 52.42万 - 项目类别:
Neural dynamics of human working memory networks
人类工作记忆网络的神经动力学
- 批准号:
9220160 - 财政年份:2016
- 资助金额:
$ 52.42万 - 项目类别:
Neural dynamics of human working memory networks
人类工作记忆网络的神经动力学
- 批准号:
9981486 - 财政年份:2016
- 资助金额:
$ 52.42万 - 项目类别:
Investigating brain network dynamics with simultaneous TMS-fMRI
利用同步 TMS-fMRI 研究大脑网络动态
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8822929 - 财政年份:2014
- 资助金额:
$ 52.42万 - 项目类别:
Investigating brain network dynamics with simultaneous TMS-fMRI
利用同步 TMS-fMRI 研究大脑网络动态
- 批准号:
8685046 - 财政年份:2014
- 资助金额:
$ 52.42万 - 项目类别:
Mechanisms of Neuroplasticity in Functional Brain Networks
功能性大脑网络的神经可塑性机制
- 批准号:
8608615 - 财政年份:2013
- 资助金额:
$ 52.42万 - 项目类别:
Mechanisms of Neuroplasticity in Functional Brain Networks
功能性大脑网络的神经可塑性机制
- 批准号:
8990057 - 财政年份:2013
- 资助金额:
$ 52.42万 - 项目类别:
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