CSHL 2019 Eukaryotic DNA Replication & Genome Maintenance Conference

CSHL 2019 真核 DNA 复制

• 批准号: 9754400
• 负责人: DAVID J. STEWART
• 金额: $ 1万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754400
• 关键词: American; Animal Genetics; Archives; Area; Asians; Award; Bacteria; Biochemistry; Biology; Cell Cycle; Cell Cycle Progression; Cell Nucleus; Cells; Chromatin; Chromatin Structure; Chromosomes; Collaborations; Complement; DNA replication fork; Data; Development; Disease; Drosophila genus; Drug resistance; Ensure; Environment; Epigenetic Process; Eukaryota; European; Event; Faculty; Feedback; Fostering; Gene Amplification; Generations; Genetic; Genetic Materials; Genetic Transcription; Genome; Genome Stability; Genomic Instability; Genomics; Goals; Growth; Industrialization; International; Internet; Investigation; Laboratories; Lead; Learning; Length of Stay; Life; Maintenance; Malignant Neoplasms; Mammalian Cell; Minority; Molecular; Molecular Biology; Mutagenesis; Oral; Organism; Participant; Peer Review; Peptide Initiation Factors; Play; Postdoctoral Fellow; Process; Proteins; Published Comment; Radiation therapy; Reading; Regulation; Replication Initiation; Replication-Associated Process; Research; Research Institute; Research Personnel; Role; S Phase; Schedule; Science; Scientist; Selection Criteria; Senior Scientist; Series; Signal Transduction; Structure; System; Time; Vascular Plant; Woman; Work; Xenopus; Yeasts; anticancer research; biological adaptation to stress; biological research; biophysical techniques; cancer cell; career; cell growth; chromosome replication; event cycle; experience; fundamental research; genome integrity; graduate student; improved; interest; lectures; meetings; posters; rapid growth; repaired; replication stress; response; success; symposium; tumor; unpublished works

2019 CSHL CONFERENCE ON EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE PROJECT SUMMARY/ABSTRACT This conference will be the 17th biennial meeting on Eukaryotic DNA Replication and Genome Maintenance and follows the highly successful meetings that have been held at Cold Spring Harbor every other year since September 1987. It is the only regularly occurring meeting that is exclusively focused on eukaryotic DNA replication. Because of this focus, the meeting has played a major role in the rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle. This year's conference will be devoted to fundamental research topics related to chromosome duplication, structure and function, and will include important areas of biological research in the areas of cell cycle and growth control, genomic amplification, and the response of the replication apparatus to DNA damage. As the field has moved forward over the past decade, we have placed an increased emphasis on the central role of DNA replication in the DNA damage and replication stress response, and strategies used by cells to minimize threats to genomic integrity arising from DNA replication. The rapid convergence of the DNA replication and DNA damage response fields makes this a timely meeting. The format of the meeting will ensure that recent results are communicated and discussed face-to-face, which will enhance progress and collaboration. The participation of young investigators, minority, and women scientists is strongly encouraged. The 2019 meeting will include a diverse array of topics, systems, and approaches including studies of chromosomal replication and gene amplification in organisms as diverse as bacteria, yeast, Drosophila, Xenopus and mammalian cells. Sessions will cover (1) Replication Initiation Factors and Origin Activation; (2) Replication Timing and Origin Control in the Cell Cycle (3) Mechanisms for Replisome Assembly, Replication Fork Progression and Termination; (4) Cellular Responses to Replication Fork Stalling and Checkpoint Activation; (5) Integration of DNA Replication with Transcription; (6) Effects of DNA Damage on Replication and Mutagenesis; (7) Roles of Chromatin on Replication and Development; (8) Effects of Dysfunctional DNA Replication on Genome Instability, Cancer and Other Diseases. Uncontrolled DNA replication is a hallmark of tumors and errors in DNA replication lead to genomic instability, while the process of chromosome replication is a major target for chemo- and radiotherapy. The relevance of this meeting to cancer research, and ultimately to improved therapies, cannot be overemphasized. Replication of DNA is a fundamental process in all (eukaryotic) life. This meeting will focus on understanding the mechanism by which this process occurs, and how DNA replication contributes to genome stability and maintenance of the epigenetic state of a cell. The intellectual merits of this conference include the opportunity for leading investigators at all stages of their scientific careers to share and discuss their latest results and concepts. The informal peer review in oral and poster sessions is invaluable in providing rapid feedback that will fruitfully steer and accelerate future research. This conference also provides ample opportunity for learning and for building collaborations. We do not plan parallel sessions within the schedule so that all attendees share a common experience, while the secluded venue maximizes the likelihood of productive scientific exchange. Large, established conferences generally can have significant impact, and this Cold Spring meeting has undoubtedly driven forward research in DNA replication. Unique aspects of this conference that have particularly broad impact are the active participation of younger scientists who will particularly benefit from the opportunity to present their latest ideas. The conference archive (Leading strand video archive accessible by the internet) allows participants to share aspects of the conference with their colleagues who were unable to attend while protecting the right of the presenting authors to present unpublished research.

2019 CSHL真核DNA复制与基因组维护会议 项目总结/摘要 本次会议将是第17届真核DNA复制和基因组两年一度的会议 维护和遵循在冷泉港举行的非常成功的会议， 自1987年9月以来，这是唯一一个定期举行的会议，专门集中在 真核DNA复制由于这一重点，会议在快速增长中发挥了重要作用， 我们对真核DNA复制过程的理解以及它如何整合到细胞分裂周期中。 今年的会议将致力于与染色体复制相关的基础研究主题， 结构和功能，并将包括生物学研究的重要领域，在细胞周期和 生长控制、基因组扩增和复制装置对DNA损伤的反应。为 在过去十年中，该领域取得了进展，我们更加强调 DNA复制中的DNA损伤和复制应激反应，以及细胞所采用的策略， DNA复制对基因组完整性的威胁。DNA复制的快速融合， DNA损伤反应场使这是一个及时的会议。会议的形式将确保最近 面对面交流和讨论成果，这将促进进展和协作。的 大力鼓励年轻研究人员、少数民族和女科学家的参与。 2019年的会议将包括各种各样的主题，系统和方法，包括研究 在细菌、酵母、果蝇等多种生物体中， 非洲爪蟾和哺乳动物细胞。会议将涵盖（1）复制启动因子和起源激活;（2） 细胞周期中的复制时间和起源控制（3）复制体组装、复制的机制 分叉进展和终止;（4）细胞对复制分叉停滞和检查点的反应 激活;（5）DNA复制与转录的整合;（6）DNA损伤对复制的影响 （7）染色质在复制和发育中的作用;（8）DNA功能障碍的影响 复制对基因组不稳定性、癌症和其他疾病的影响。不受控制的DNA复制 肿瘤和DNA复制中的错误导致基因组不稳定，而染色体复制过程 是化疗和放疗的主要目标。本次会议与癌症研究的相关性，以及 最终改进治疗方法，这一点怎么强调都不过分。 DNA的复制是所有（真核）生命的基本过程。本次会议将重点讨论 了解这一过程发生的机制，以及DNA复制如何有助于基因组 稳定和维持细胞的表观遗传状态。这次会议的学术价值包括： 在他们的科学生涯的各个阶段，领先的研究人员有机会分享和讨论他们的最新 结果和概念。在口头和海报会议上进行的非正式同行审查在提供快速 这些反馈将有效地引导和加速未来的研究。本次会议还提供了丰富的 学习和建立合作的机会。我们不计划在时间表内并行会议 使所有与会者分享共同的经验，而僻静的场地最大限度地提高了可能性， 富有成效的科学交流。 大型的、既定的会议通常会产生重大影响，这次冷泉会议 无疑推动了DNA复制的研究。这次会议的独特之处在于， 特别广泛的影响是年轻科学家的积极参与，他们将特别受益于 有机会展示他们的最新想法。会议档案（领先的视频档案， 因特网）使与会者能够与无法与之交流的同事分享会议的各个方面。 出席会议，同时保护提交作者提交未发表研究的权利。