Macrophage lineage phenotypes

巨噬细胞谱系表型

• 批准号: nhmrc : 509218
• 负责人: Prof John Hamilton
• 金额: $ 42.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/macrophage-lineage-phenotypes/81187
• 关键词: Macrophage; lineage; phenotypes

A type of white blood cell, the macrophage, is a key player in determining the chronicity of inflammatory conditions such as rheumatoid arthritis, atherosclerosis, psoriasis, nephritis, multiple sclerosis etc. Two particular proteins can control macrophage development and functions, both under normal conditions and during inflammation. The project aims to understand this control. More rational ways to suppress inflammation due to aberrant macrophage function should result.

巨噬细胞是一种白细胞，在决定类风湿性关节炎、动脉粥样硬化、银屑病、肾炎、多发性硬化症等炎症条件的慢性化方面起着关键作用。有两种特殊的蛋白质可以控制巨噬细胞的发育和功能，无论是在正常条件下还是在炎症过程中。该项目旨在了解这种控制。应该有更合理的方法来抑制由于巨噬细胞功能异常引起的炎症。