"Persistent particles" and monocyte/macrophage function

“持久颗粒”和单核细胞/巨噬细胞功能

• 批准号: nhmrc : 114204
• 负责人: Prof John Hamilton
• 金额: $ 23.75万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/persistent-particles-monocytemacrophage-function/97533
• 关键词: Persistent; particles; monocyte; macrophage; function

The project studies how a type of white blood cell interacts with damaged tissue at a site of inflammation, such as an occluded vessel or a brain plaque, and also with immunological adjuvants. It is believed that the nature of the material to be removed is critical in determining the effect on the white blood cell such that it can stay longer at the site and cause more damage or stimulate more immunity, respectively. The ultimate goal is to understand the cellular biochemistry responsible to help diseases, such as atherosclerosis and Alzheimer's disease, and to improve the quality of human adjuvants.

该项目研究一种白细胞如何与炎症部位的受损组织（如闭塞的血管或脑斑块）以及免疫佐剂相互作用。据信，要去除的物质的性质对于确定对白细胞的影响至关重要，因此白细胞可以在该部位停留更长时间，分别造成更大的损害或刺激更多的免疫力。最终目标是了解帮助疾病的细胞生物化学，如动脉粥样硬化和阿尔茨海默病，并提高人类佐剂的质量。