Macrophage lineage contribution to breast cancer metastasis

巨噬细胞谱系对乳腺癌转移的贡献

• 批准号: nhmrc : 1008802
• 负责人: Prof John Hamilton
• 金额: $ 40.17万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/macrophage-lineage-contribution-cancer-metastasis/109342
• 关键词: Macrophage; lineage; contribution; breast; cancer

When diagnosed early, breast cancer can be treated with a high degree of success. However, if the cancer spreads to other organs such as lungs and bone, patients suffer from severe pain and debilitating symptoms that often lead to death. Therapies for patients with advanced disease are extremely limited. It is the aim of this project to define the role that macrophages and stromal fibroblasts play in assisting the tumour cells to spread around the body and grow in other tissues.

如果早期诊断，乳腺癌可以得到高度成功的治疗。然而，如果癌症扩散到其他器官，如肺和骨骼，患者会遭受严重的疼痛和衰弱症状，往往导致死亡。晚期疾病患者的治疗方法极其有限。该项目的目的是确定巨噬细胞和基质成纤维细胞在帮助肿瘤细胞在身体周围扩散和在其他组织中生长中所起的作用。