TARGETING OF G-CSF IN COMBINATION WITH STANDARD THERAPY FOR ADVANCED BREAST CANCER

靶向 G-CSF 与标准疗法相结合治疗晚期乳腺癌

• 批准号: nhmrc : 1080560
• 负责人: Prof John Hamilton
• 金额: $ 38.89万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-g-csf-breast-cancer/518757
• 关键词: TARGETING; CSF; COMBINATION; STANDARD; THERAPY

Nearly all deaths caused by breast cancer are due to the spread of the cancer to other tissues such as lung and bone, ultimately leading to organ failure and death. The process of spread of cancer cells is not well understood, but it is becoming clear that cells of the immune system are key regulators of the spread of breast cancer. It is the aim of this project to target two types of immune cells, macrophages and neutrophils, seeking therapies that prevent the growth of secondary cancers.

几乎所有由乳腺癌引起的死亡都是由于癌症扩散到其他组织，如肺和骨骼，最终导致器官衰竭和死亡。癌细胞扩散的过程还不清楚，但免疫系统细胞是乳腺癌扩散的关键调节因子，这一点越来越清楚。该项目的目标是针对两种类型的免疫细胞，巨噬细胞和中性粒细胞，寻求预防继发性癌症生长的疗法。