Core D - Biostatistics/Bioinformatics

核心 D - 生物统计学/生物信息学

• 批准号: 9756331
• 负责人: GIDEON D ZAMBA
• 金额: $ 25.29万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756331
• 关键词: Archives; Area; Basic Science; Bioinformatics; Biometry; Chemistry; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Complement; Comprehensive Cancer Center; Computational Biology; Correlative Study; Data; Data Analyses; Data Collection; Data Management Resources; Databases; Development; Drug Kinetics; Engineering; Event; Experimental Designs; G-Protein-Coupled Receptors; Gene Chips; Gene Expression; Gene Mutation; Genome; Genomics; Genotype; Human; Human Resources; Image; Individual; Informatics; Information Management; Iowa; Laboratories; Leadership; Longterm Follow-up; Malignant Neoplasms; Manuscripts; Monitor; Mutation; Nature; Neuroendocrine Tumors; Neurosecretory Systems; Normal tissue morphology; Outcomes Research; Pharmacology; Phenotype; Population; Population Sciences; Preparation; Procedures; Public Health; Publications; Quality Control; Quality of life; Registries; Research; Research Design; Research Personnel; Safety; Sampling; Schools; Specialized Program of Research Excellence; System; The Cancer Genome Atlas; Therapeutic Trials; Tissues; Translational Research; Tumor Initiators; Tumor Suppressor Genes; Tumor Tissue; Universities; Update; Work; adverse event monitoring; cancer genome; career development; college; control trial; data archive; data integration; data management; database of Genotypes and Phenotypes; design; exome sequencing; experience; genomic data; innovation; investigator training; neoplasm resource; next generation sequencing; programs; receptor expression; response; tissue registry; translational clinical trial; tumor; tumor registry

The Biostatistics and Bioinformatics Core provides integrative statistical and informatics support to the Iowa Neuroendocrine Tumor (NET) SPORE. This support is provided to the SPORE: projects, developmental projects and associated cores. The comprehensive nature of the Core encompasses basic, translational, and clinical projects, assuring each SPORE investigator access to expertise that includes development of study designs, state of the art data analysis and interpretation, data management resources, abstract and manuscript preparation, and synergistic interaction with all other core components through gate keeping and analyses information sharing. The Core builds upon the innovative procedures and systems in the University of Iowa Holden Comprehensive Cancer Center, the Department of Biostatistics in the College of Public Health and the Coordinated Laboratory for Computational Genomics in the School of Engineering. Design and analysis support has been and will be provided across a range of fields, including basic chemistry and pharmacology, exome sequencing and mutation discovery, expression analysis, imaging pharmacokinetics and dosimety, clinical trials, and population science. The Core designed, developed, and will continue to upgrade the Iowa Neuroendocrine Tumor Database. Support is also provided for the management and integration of existing and newly collected data through consistent and compatible genomic data handling. Additional areas of support for clinical trials include data form development and processing, data collection and entry, data archiving, quality control, and data safety monitoring. In addition to being actively involved with the preparation of statistical plans for the four projects in this application, the Core was also involved in the management of information pertaining to Exome sequencing, gene mutation identification and analysis of G-protein coupled receptor expression. The Core has and will continue to provide statistical experimental design, data analysis and management for all studies, and preparation of data summaries for manuscript publication. In summary, strengths of the Biostatistics and Bioinformatics Core are complete integration into, and synergistic interaction with, each of the SPORE projects and associated cores, the unique Iowa Neuroendocrine Tumor Database incorporating both genotypic and phenotypic information, and the breadth of expertise provided by the Biostatistics and Bioinformatics personnel.

生物统计学和生物信息学核心为爱荷华州提供综合统计和信息学支持。 神经内分泌肿瘤（NET）孢子。这种支持是提供给孢子：项目，发展 项目和相关核心。核心的综合性质包括基本的，翻译的， 临床项目，确保每位SPORE研究者获得专业知识，包括研究开发 设计、最先进的数据分析和解释、数据管理资源、摘要和手稿 通过把关和分析， 信息共享核心建立在爱荷华州大学的创新程序和系统之上 霍尔顿综合癌症中心，公共卫生学院生物统计学系和 工程学院计算基因组学协调实验室。设计与分析 已经并将在一系列领域提供支持，包括基础化学和药理学， 外显子组测序和突变发现，表达分析，成像药代动力学和剂量学， 临床试验和人口科学。核心设计，开发，并将继续升级爱荷华州 神经内分泌肿瘤数据库。还为管理和整合现有的 通过一致和兼容的基因组数据处理新收集的数据。其他支助领域 临床试验包括数据表开发和处理、数据收集和录入、数据存档、质量 监控和数据安全。除了积极参与编制统计资料外， 在这四个项目的规划申请中，还涉及了核心信息的管理 属于外显子组测序、基因突变鉴定和G蛋白偶联受体分析 表情核心已经并将继续提供统计实验设计、数据分析和 管理所有研究，并为手稿出版准备数据摘要。总的来说， 生物统计学和生物信息学核心的优势是完全整合和协同互动 每个SPORE项目和相关核心都有独特的爱荷华州神经内分泌肿瘤数据库 结合基因型和表型信息，以及 生物统计学和生物信息学人员。