Pancreatic Diseases Gordon Research Conference

项目总结/摘要 近年来，我们对参与这些疾病的分子机制的理解取得了快速进展， 胰腺的发育、再生和恶性转化，以及我们模拟这些的能力。 在小鼠和最近也在人类细胞中的过程。这些研究揭示了 不同的胰腺细胞类型和对环境影响的可塑性。在临床层面， 流行病学研究表明，胰腺疾病，特别是糖尿病之间存在明显的联系， 和胰腺癌然而，胰腺疾病共同发生的机制并不清楚， 明白这个相对较新的GRC旨在将外分泌和内分泌生物学的理解联系起来 胰腺应用于人类疾病。这个GCR是独一无二的，因为它是唯一的会议， 来自胰腺生物学各个方面的专家以及致力于转化方法的临床医生， 糖尿病、胰腺癌和胰腺炎。通过提供一个论坛，介绍和讨论切割 边缘，未发表的概念和方法，这个GRC的目标是激发跨领域的讨论， 学科这种交流将促进该领域的跨学科方法，并促进思想交流 和经验，以导致新的合作，以及授权年轻科学家展示他们的工作， 同行和领导者在该领域。 继前几次会议的成功之后，第四次GRC“胰腺疾病”将在 约旦酒店，星期日河，ME，美国，2019年6月16日至21日。会议将重点关注了解细胞 行为和环境的影响，目的是深入了解如何在胰腺疾病， 全身和局部环境影响健康和疾病中内分泌和外分泌细胞的状态。的 已经组装的程序是一流的，受益于国际世界级的贡献 从事胰腺疾病不同方面相关研究的科学家。的最终目标 会议是确定胰腺疾病的新概念，可能是可利用的， 药理学和基于细胞的治疗方法。对于所有GRCs，本次会议的指导原则 是展示新的、未发表的结果，以及随后自由、不受阻碍的讨论。参与 特别强调了青年科学家，包括博士生、博士后和青年组组长的作用， 简短的演讲和海报展示的机会。

PROJECT SUMMARY/ABSTRACT Recent years have brought rapid advances in our understanding of the molecular mechanisms involved in pancreatic development, regeneration, and malignant transformation, as well as our ability to model these processes in mice and recently also human cells. These studies have revealed lineage relationships between the different pancreatic cell types and plasticity in response to environmental influences. At the clinical level, epidemiological studies show a clear association between pancreatic diseases, in particular between diabetes and pancreatic cancer. Yet, the mechanisms that underlie the co-occurrence of pancreatic diseases are poorly understood. This relatively new GRC aims to link the understanding of the biology of the exocrine and endocrine pancreas to applications for human diseases. This GCR is unique in that it is the only conference that convenes experts from all aspects of pancreas biology as well as clinicians working on translational approaches for diabetes, pancreatic cancer and pancreatitis. By providing a forum for the presentation and discussion of cutting edge, unpublished concepts and approaches, the goal of this GRC is to stimulate discussion across fields and disciplines. This exchange will foster interdisciplinary approaches in the field and promote exchange of ideas and experiences to lead to new collaborations, as well as empower young scientists to showcase their work to peers and leaders in the field. Following the success of the previous conferences, the fourth GRC "Pancreatic Diseases" will take place at the Jordan Hotel, Sunday River, ME, USA from June 16 - 21, 2019. The conference will focus on understanding cell behavior and environmental influences in pancreatic diseases with the goal of gaining insights into how the systemic and local environment impacts the state of endocrine and exocrine cells in health and disease. The program that has been assembled is first-rate, benefitting from the contribution of international world-class scientists engaged in research relevant to different aspects of pancreatic diseases. The ultimate goal of the conference is the identification of novel concepts in pancreatic diseases that might be exploitable for pharmacological and cell-based therapeutic approaches. As for all GRCs, the guiding principle of this conference is the presentation of new, unpublished results and the free, unhampered discussion that follows. Participation of young scientists, including PhD students, postdocs and junior group leaders is especially emphasized, with opportunities of short talks and poster presentations.