Adolescent Alcohol Abuse, Traumatic Stress, and Vulnerability to Development of PTSD
青少年酗酒、创伤性应激和易患创伤后应激障碍 (PTSD)
基本信息
- 批准号:10544336
- 负责人:
- 金额:$ 45.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescenceAdolescentAdultAge of OnsetAlcohol abuseAlcohol consumptionAlcohol dependenceAlcoholismAmygdaloid structureAnxiety DisordersBehaviorBehavior ControlBehavioralBrainBrain regionCharacteristicsCommunicationComplexCuesDataDevelopmentDiseaseElectrophysiology (science)EthanolEventExhibitsExposure toExtinctionFinancial HardshipFrightGRM5 geneHigh PrevalenceHumanIndividualInhalationKnowledgeLearningLifeMeasuresMedialMediatingMental disordersModelingNeuronsPatientsPersonsPhasePhysiologicalPlayPost-Traumatic Stress DisordersPredispositionPrefrontal CortexProceduresRattusRecording of previous eventsResearchRiskRisk FactorsRoleSelf AdministrationSex DifferencesSiteStimulusStressStress and CopingTestingadolescent alcohol abuseadolescent alcohol exposurealcohol exposurealcohol relapsealcohol seeking behavioralcohol use disorderbiological adaptation to stressclinically relevantcognitive processcomorbidityconditioned fearcopingcritical perioddesigndrinking behavioreffective therapyemerging adultexperienceexperimental studyheart rate variabilityhigh riskin vivoinnovationinterestmalememory processneural circuitneuromechanismneuropathologynoveloptogeneticspharmacologicreceptorsensorsocialstress reductionstress resiliencetraumatic eventtraumatic stressunderage drinkingvapor
项目摘要
7. PROJECT SUMMARY/ABSTRACT
Post-Traumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD) are two of the most prevalent
psychiatric conditions and are highly comorbid. The social and financial burden that results from a lack of
effective treatments for these disorders is enormous. Therefore, there is a clear and urgent need to gain a greater
understanding of the pathophysiological basis of PTSD and AUD comorbidity. Current evidence suggests the
neurocircuitry of PTSD and AUD significantly overlap, which includes dysfunctional control of behavior by the
prefrontal cortex (PFC). Thus, alterations in prefrontal mediated cognitive processes that regulate behavior may
contribute to the high comorbidity of the disorders. There is a strong correlation between the age of onset of
alcohol use during adolescence and the likelihood of developing an AUD later in life. In addition, adolescence is
a critical period of continued development, and accumulating evidence indicates that the abuse of alcohol during
adolescence can have long-term consequences on brain and behavior. Considering the high prevalence of
adolescent alcohol abuse, it is therefore surprising that little research has focused on understanding its impact
on an individual’s ability to cope with a traumatic stress event in adulthood. The overarching hypothesis of this
proposal is that adults with a history of adolescent alcohol abuse who experience a traumatic stress event have
reduced stress resiliency and are at a significantly higher risk of developing PTSD and AUD. This experimental
approach takes advantage of a binge ethanol model consisting of repeated cycles of Adolescent Intermittent
Ethanol (AIE) exposure by vapor inhalation and a Single Prolonged Stress (SPS) procedure that is thought to
model a traumatic stress event in humans. Following AIE and SPS exposure in early adulthood, rats will then be
tested for alterations in fear behavior and ethanol self-administration. The following three specific aims are
designed to test the overarching hypothesis: Aim 1 will test the hypothesis that exposure to AIE-SPS results in
pharmacologically reversible alterations in fear-related behaviors. Aim 2 will test the hypothesis that exposure to
AIE-SPS increases alcohol consumption and relapse-like behavior induced by exposure to fear conditioned
cues. Aim 3 will test the hypothesis that AIE-SPS induced alterations of fear behaviors reflect alterations in
prelimbic and infralimbic communication with core regions of the fear neurocircuitry. Findings from these novel
and innovative studies will significantly advance our understanding of the behavioral deficits and neural
mechanisms underlying the complex interactions between AUD and PTSD, and whether a history of adolescent
alcohol abuse may represent a pre-existing risk factor that increases susceptibility of developing not only PTSD
associated with a traumatic event but also AUD.
7. 项目总结/文摘
项目成果
期刊论文数量(0)
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{{ truncateString('L Judson Chandler', 18)}}的其他基金
Adolescent Alcohol Abuse, Traumatic Stress, and Vulnerability to Development of PTSD
青少年酗酒、创伤性应激和易患创伤后应激障碍 (PTSD)
- 批准号:
9917259 - 财政年份:2020
- 资助金额:
$ 45.04万 - 项目类别:
Adolescent Alcohol Abuse, PTSD and Alzheimer's Disease Administrative Supplement
青少年酒精滥用、创伤后应激障碍和阿尔茨海默病行政补充
- 批准号:
10715295 - 财政年份:2020
- 资助金额:
$ 45.04万 - 项目类别:
Adolescent Alcohol Abuse, Traumatic Stress, and Vulnerability to Development of PTSD
青少年酗酒、创伤性应激和易患创伤后应激障碍 (PTSD)
- 批准号:
10318965 - 财政年份:2020
- 资助金额:
$ 45.04万 - 项目类别:
Chronic Intermittent Ethanol and Kv4.2 Channels
慢性间歇性乙醇和 Kv4.2 通道
- 批准号:
8888766 - 财政年份:2015
- 资助金额:
$ 45.04万 - 项目类别:
Impact of Adolescent Alcohol Exposure on Prefrontal Cortical Function in the Adul
青少年酒精暴露对成人前额皮质功能的影响
- 批准号:
8530113 - 财政年份:2010
- 资助金额:
$ 45.04万 - 项目类别:
6/8 NADIA U01 Adolescent Alcohol and Prefrontal Cortical Function in the Adult
6/8 NADIA U01 青少年酒精与成人前额皮质功能
- 批准号:
10480953 - 财政年份:2010
- 资助金额:
$ 45.04万 - 项目类别:
Impact of Adolescent Alcohol Exposure on Prefrontal Cortical Function in the Adul
青少年酒精暴露对成人前额皮质功能的影响
- 批准号:
8317723 - 财政年份:2010
- 资助金额:
$ 45.04万 - 项目类别:
Impact of Adolescent Alcohol Exposure on Prefrontal Cortical Function in the Adul
青少年酒精暴露对成人前额皮质功能的影响
- 批准号:
8716610 - 财政年份:2010
- 资助金额:
$ 45.04万 - 项目类别:
Adolescent Alcohol and Prefrontal Cortical Function in the Adult
青少年酒精与成人前额皮质功能
- 批准号:
9756243 - 财政年份:2010
- 资助金额:
$ 45.04万 - 项目类别:
Impact of Adolescent Alcohol Exposure on Prefrontal Cortical Function in the Adul
青少年酒精暴露对成人前额皮质功能的影响
- 批准号:
8030692 - 财政年份:2010
- 资助金额:
$ 45.04万 - 项目类别:
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