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Adolescent Alcohol Abuse, Traumatic Stress, and Vulnerability to Development of PTSD

青少年酗酒、创伤性应激和易患创伤后应激障碍 (PTSD)

基本信息

批准号：
10544336
负责人：
L Judson Chandler
金额：
$ 45.04万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10544336
关键词：
Address Adolescence Adolescent Adult Age of Onset Alcohol abuse Alcohol consumption Alcohol dependence Alcoholism Amygdaloid structure Anxiety Disorders Behavior Behavior Control Behavioral Brain Brain region Characteristics Communication Complex Cues Data Development Disease Electrophysiology (science)Ethanol Event Exhibits Exposure to Extinction Financial Hardship Fright GRM5 gene High Prevalence Human Individual Inhalation Knowledge Learning Life Measures Medial Mediating Mental disorders Modeling Neurons Patients Persons Phase Physiological Play Post-Traumatic Stress Disorders Predisposition Prefrontal Cortex Procedures Rattus Recording of previous events Research Risk Risk Factors Role Self Administration Sex Differences Site Stimulus Stress Stress and Coping Testing adolescent alcohol abuse adolescent alcohol exposure alcohol exposure alcohol relapse alcohol seeking behavior alcohol use disorder biological adaptation to stress clinically relevant cognitive process comorbidity conditioned fear coping critical period design drinking behavior effective therapy emerging adult experience experimental study heart rate variability high risk in vivo innovation interest male memory process neural circuit neuromechanism neuropathology novel optogenetics pharmacologic receptor sensor social stress reduction stress resilience traumatic event traumatic stress underage drinking vapor

项目摘要

7. PROJECT SUMMARY/ABSTRACT Post-Traumatic Stress Disorder (PTSD) and Alcohol Use Disorder (AUD) are two of the most prevalent psychiatric conditions and are highly comorbid. The social and financial burden that results from a lack of effective treatments for these disorders is enormous. Therefore, there is a clear and urgent need to gain a greater understanding of the pathophysiological basis of PTSD and AUD comorbidity. Current evidence suggests the neurocircuitry of PTSD and AUD significantly overlap, which includes dysfunctional control of behavior by the prefrontal cortex (PFC). Thus, alterations in prefrontal mediated cognitive processes that regulate behavior may contribute to the high comorbidity of the disorders. There is a strong correlation between the age of onset of alcohol use during adolescence and the likelihood of developing an AUD later in life. In addition, adolescence is a critical period of continued development, and accumulating evidence indicates that the abuse of alcohol during adolescence can have long-term consequences on brain and behavior. Considering the high prevalence of adolescent alcohol abuse, it is therefore surprising that little research has focused on understanding its impact on an individual’s ability to cope with a traumatic stress event in adulthood. The overarching hypothesis of this proposal is that adults with a history of adolescent alcohol abuse who experience a traumatic stress event have reduced stress resiliency and are at a significantly higher risk of developing PTSD and AUD. This experimental approach takes advantage of a binge ethanol model consisting of repeated cycles of Adolescent Intermittent Ethanol (AIE) exposure by vapor inhalation and a Single Prolonged Stress (SPS) procedure that is thought to model a traumatic stress event in humans. Following AIE and SPS exposure in early adulthood, rats will then be tested for alterations in fear behavior and ethanol self-administration. The following three specific aims are designed to test the overarching hypothesis: Aim 1 will test the hypothesis that exposure to AIE-SPS results in pharmacologically reversible alterations in fear-related behaviors. Aim 2 will test the hypothesis that exposure to AIE-SPS increases alcohol consumption and relapse-like behavior induced by exposure to fear conditioned cues. Aim 3 will test the hypothesis that AIE-SPS induced alterations of fear behaviors reflect alterations in prelimbic and infralimbic communication with core regions of the fear neurocircuitry. Findings from these novel and innovative studies will significantly advance our understanding of the behavioral deficits and neural mechanisms underlying the complex interactions between AUD and PTSD, and whether a history of adolescent alcohol abuse may represent a pre-existing risk factor that increases susceptibility of developing not only PTSD associated with a traumatic event but also AUD.

7. 项目总结/文摘