Pediatric HIV/AIDS Cohort Study (PHACS): Data and Operations Center (DOC).
儿科艾滋病毒/艾滋病队列研究 (PHACS):数据和运营中心 (DOC)。
基本信息
- 批准号:9757832
- 负责人:
- 金额:$ 1879.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-09-30 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:15 year old18 year oldAIDS/HIV problemAcquired Immunodeficiency SyndromeAddressAdolescentAdolescent and Young AdultAffectAgeAgreementAnti-Retroviral AgentsBiometryCaringChildClinicalCognitionCognitiveCohort StudiesCommunitiesConsequences of HIVDataData CollectionData SetDatabasesDevelopmentDrug toxicityEducational MaterialsEmotionalEnrollmentEnsureEpidemiologistEpidemiologyExposure toFamilyFoundationsGrowth and Development functionHIVHIV InfectionsHIV antiretroviralHIV-infected adolescentsHealthHealth CommunicationHealth ProfessionalHealth educationIndividualInfantInfectionLeadershipLogisticsLong-Term EffectsLongitudinal StudiesManualsMentorshipMethodologyMethodsMonitorNational Institute of Child Health and Human DevelopmentNewborn InfantParticipantPatientsPediatric HIV/AIDS Cohort StudyPerinatalPerinatal ExposurePerinatal InfectionPopulationPositioning AttributePreventionPreventivePrincipal InvestigatorProceduresProtocols documentationPublic HealthPublic Health SchoolsQuality ControlRecording of previous eventsResearchResearch DesignResearch MethodologyResearch PersonnelRiskSafetyScienceSexual MaturationSiteSocial FunctioningSocializationStudy SubjectSupervisionSystemTechnologyToxic effectTrainingTranslatingUnited StatesYouthagedbasebody systemchemotherapycohortcomparison groupcostdata managementdata sharingdesignexperiencefollow-upfrontierimprovedin uteroinnovationinstrumentleadership developmentmeetingsmemberneonatal exposureoperationpediatric human immunodeficiency virusperformance siteperinatal HIVperinatal periodpreadolescenceprenatal exposureprevention servicepublic health relevancequality assurancerecruitresearch studysuccesstreatment servicesworking groupyoung adult
项目摘要
DESCRIPTION (provided by applicant): The Pediatric HIV/AIDS Cohort Study (PHACS) was created in 2005 to evaluate the clinical course of perinatally acquired HIV infection among adolescents and pre-adolescents and the consequences of fetal and neonatal exposure to HIV and antiretroviral chemotherapy among a representative cohort of children in the United States. PHACS is comprised of a Scientific Leadership Group (SLG), which is overseen by a Coordinating Center, a Data and Operations Center (DOC), and 22 clinical units (CU). The Department of Epidemiology and the Center for Biostatistics in AIDS Research at the Harvard School of Public Health, Westat, and the Frontier Science Foundation form the PHACS DOC. The DOC collaborates with the SLG to define the PHACS research agenda; provides methodological leadership for the development of all PHACS analytic projects; maintains CU subcontracts and trains and monitors sites in proper procedures for PHACS research; plans and conducts all leadership and full PHACS network meetings; develops HIV- and health- related educational materials and opportunities for the PHACS community; and, supports an active Community Advisory Board. The Adolescent Master Protocol (AMP), a cohort of 450 perinatally HIV-infected adolescents and preadolescents age 7-16 at enrollment, was established to investigate the impact of HIV and ART on organ systems, growth and development, sexual maturation, pubertal development, cognition, emotional development, and socialization; AMP Up was subsequently designed to extend follow-up of AMP participants and other HIV-infected young adults who have reached 18 years of age using a streamlined, mobile-friendly protocol. A drug toxicity surveillance system, Surveillance Monitoring for Anti-Retroviral Toxicities (SMART), has enrolled 3,506 perinatally HIV-exposed, uninfected children to evaluate long-term effects of in-utero ART exposure. In PHACS III, the DOC will continue to carry out the PHACS scientific agenda in an increasing efficient manner, enrolling and following an additional 1,000 newborns into SMARTT and an additional 525 HIV-infected and HIV-exposed, uninfected young adults into AMP Up. Together, HSPH, Westat and Frontier Science bring a long and successful history of providing the scientific and operational leadership required by PHACS, as well as innovative methods to enhance and maximize the efficiency of the PHACS study design, conduct, and analyses. Given our prior experience we are uniquely positioned to continue to provide the scientific/epidemiologic and operational leadership essential to the continued success of PHACS.
项目成果
期刊论文数量(103)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis.
- DOI:10.1097/qad.0000000000000072
- 发表时间:2014-01-28
- 期刊:
- 影响因子:0
- 作者:Kapetanovic S;Griner R;Zeldow B;Nichols S;Leister E;Gelbard HA;Miller TL;Hazra R;Mendez AJ;Malee K;Kammerer B;Williams PL;Pediatric HIV/AIDS Cohort Study Team
- 通讯作者:Pediatric HIV/AIDS Cohort Study Team
Growth and pubertal development in HIV-infected adolescents.
- DOI:10.1097/coh.0000000000000450
- 发表时间:2018-05
- 期刊:
- 影响因子:4.1
- 作者:Williams PL;Jesson J
- 通讯作者:Jesson J
Fractures in children and adolescents living with perinatally acquired HIV.
围产期感染艾滋病毒的儿童和青少年的骨折。
- DOI:10.1016/j.bone.2020.115515
- 发表时间:2020
- 期刊:
- 影响因子:4.1
- 作者:Jacobson,DeniseL;Yu,Wendy;Hazra,Rohan;Brummel,Sean;Geffner,MitchellE;Patel,Kunjal;Borkowsky,William;Wang,Jiajia;Chen,JanetS;Mirza,Ayesha;DiMeglio,LindaA;PediatricHIV/AIDSCohortStudy
- 通讯作者:PediatricHIV/AIDSCohortStudy
Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.
围产期感染艾滋病毒的年轻人体内脂肪和代谢并发症的纵向变化。
- DOI:10.1111/hiv.13566
- 发表时间:2024
- 期刊:
- 影响因子:3
- 作者:Dirajlal-Fargo,Sahera;Jacobson,DeniseL;Yu,Wendy;Mirza,Ayesha;Geffner,MitchellE;Mccomsey,GraceA;Jao,Jennifer;PediatricHIV/AIDSCohortStudy(PHACS)
- 通讯作者:PediatricHIV/AIDSCohortStudy(PHACS)
Cardiac biomarkers in HIV-exposed uninfected children.
- DOI:10.1097/qad.0b013e32835cf21c
- 发表时间:2013-04-24
- 期刊:
- 影响因子:0
- 作者:Wilkinson JD;Williams PL;Leister E;Zeldow B;Shearer WT;Colan SD;Siberry GK;Dooley LB;Scott GB;Rich KC;Lipshultz SE;Pediatric HIVAIDS Cohort Study (PHACS)
- 通讯作者:Pediatric HIVAIDS Cohort Study (PHACS)
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{{ truncateString('PAIGE L WILLIAMS', 18)}}的其他基金
Surveillance Monitoring for ART Toxicities (SMARTT) Study
ART 毒性监测 (SMARTT) 研究
- 批准号:
10663919 - 财政年份:2020
- 资助金额:
$ 1879.26万 - 项目类别:
Surveillance Monitoring for ART Toxicities (SMARTT) Study
ART 毒性监测 (SMARTT) 研究
- 批准号:
10065443 - 财政年份:2020
- 资助金额:
$ 1879.26万 - 项目类别:
Surveillance Monitoring for ART Toxicities (SMARTT) Study
ART 毒性监测 (SMARTT) 研究
- 批准号:
10264952 - 财政年份:2020
- 资助金额:
$ 1879.26万 - 项目类别:
STATISTICAL PROBLEMS IN BIOASSAY AND RISK ASSESSMENT
生物测定和风险评估中的统计问题
- 批准号:
6030244 - 财政年份:1996
- 资助金额:
$ 1879.26万 - 项目类别:
STATISTICAL PROBLEMS IN BIOASSAY AND RISK ASSESSMENT
生物测定和风险评估中的统计问题
- 批准号:
2734297 - 财政年份:1996
- 资助金额:
$ 1879.26万 - 项目类别:
STATISTICAL PROBLEMS IN BIOASSAY AND RISK ASSESSMENT
生物测定和风险评估中的统计问题
- 批准号:
2157456 - 财政年份:1996
- 资助金额:
$ 1879.26万 - 项目类别:
STATISTICAL PROBLEMS IN BIOASSAY AND RISK ASSESSMENT
生物测定和风险评估中的统计问题
- 批准号:
6178551 - 财政年份:1996
- 资助金额:
$ 1879.26万 - 项目类别:
STATISTICAL PROBLEMS IN BIOASSAY AND RISK ASSESSMENT
生物测定和风险评估中的统计问题
- 批准号:
2444233 - 财政年份:1996
- 资助金额:
$ 1879.26万 - 项目类别:
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