ADMINISTRATIVE SUPPLEMENT TO GRANT R01-AG057424, Short-term Measurements of Physical Resilience as a Predictor of Healthspan in Mice.

这一行政补充申请代表了一个新的机会， 由NIA资助的老年病理学的老年病理学分级平台（GGP）的最新发展 中国互联网.这种新颖的小鼠病理学评估方法， 格兰特提交了。请求提供资金以支付兽医Breshears博士的薪金 病理学家，谁将使用最近开发的GGP来评估动物的健康状况， 在目标2和目标3中测试它们的抗压能力。这里要求的补充将允许我们使用 新开发的GGP用于测量相同小鼠的整体病理学， 抗压能力在测试了小鼠的恢复力后，它们将被终止，全球 将通过GGP评估每只动物的病理状态。因为病理性的 病变是衰老的标志，小鼠的整体病理状态为我们提供了健康寿命的衡量标准。 因此，我们将能够确定我们的恢复力指标在多大程度上预测了小鼠的健康寿命 我们在学习。此外，这些实验将首次使用GGP来评估 干预措施，如饮食限制，阿卡波糖，17-α-雌二醇对全球病理学。

This administrative supplement application represents a new opportunity that has arisen from the recent development of the Geropathology Grading Platform (GGP) by the NIA funded Geropathology Research Network. This novel assessment of mouse pathology was only fully developed after the parent grant was submitted. Funds are requested to support the salary of Dr. Breshears, a veterinary pathologist, who will use the recently developed GGP to assess health status of the animals that will be tested in Aims 2 and 3 for their resilience to stress. The supplement requested here will allow us to use the newly developed GGP to measure global pathology in the same mice that we will use to measure resilience to stress. After the mice have been tested for resilience, they will be terminated, and the global pathological status of each animal will be assessed by the GGP. Because the occurrence of pathological lesions is a hallmark of aging, the global pathological status of the mice gives us a measure of healthspan. Thus, we will be able to determine how well our measures of resilience predict the healthspan of the mice we are studying. In addition, these experiments will be the first to use the GGP to assess the effect of interventions such as dietary restriction, acarbose, and 17-α-estradiol on global pathology.