Maternal Immune Activation and Fetal-Infant Neurobehavioral Development

母体免疫激活和胎儿-婴儿神经行为发育

• 批准号: 9527362
• 负责人: Marisa N Spann
• 金额: $ 16.02万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9527362
• 关键词: Academic Medical Centers; Affect; Age; Age-Months; Anterior; Area; Autistic Disorder; Behavior; Behavior assessment; Behavioral; Behavioral Paradigm; Biological Assay; Birth; Blood; Brain; C-reactive protein; Child; Childhood; Clinical; Clinical Research; Cognition; Data; Data Collection; Data Set; Development; Diagnosis; Dorsal; Early Diagnosis; Early Intervention; Early identification; Enrollment; Ensure; Epidemiologic Methods; Exposure to; Fetal Movement; Fetus; First Pregnancy Trimester; Future; Goals; Growth; Head circumference; Health; Hospitals; Human; Immune; Immunoglobulin G; Immunologics; Immunology; Infant; Infant Behavior; Infection; Inflammatory; Influenza; Institution; Insula of Reil; Intellectual functioning disability; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Lead; Learning Disabilities; Level of Evidence; Life; Magnetic Resonance Imaging; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Motor; Neonatal; Neurobiology; Neurodevelopmental Disorder; Neurosciences; Nursery Schools; Pattern; Performance; Perinatal; Perinatal Epidemiology; Positioning Attribute; Postpartum Period; Pregnancy; Pregnant Women; Premature Birth; Public Health; Research; Research Design; Research Personnel; Research Training; Risk; Rodent; Sampling; Second Pregnancy Trimester; Services; Statistical Models; Stimulus; Stress; Symptoms; Temperament; Third Pregnancy Trimester; Time; Toxic Environmental Substances; Training; Training Activity; Work; base; biobehavior; brain behavior; brain size; brain volume; career; cingulate cortex; cohort; endophenotype; environmental stressor; epidemiology study; experience; fetal; fetal reactivity; immune activation; improved; indexing; individual variation; infancy; inflammatory marker; innovation; morphometry; neonatal brain; neonate; neurobehavior; neurobehavioral; neurobehavioral disorder; neurodevelopment; neuroimaging; nonhuman primate; novel; offspring; pathogen; perinatal period; physical conditioning; population based; prenatal; programs; protein biomarkers; psychologic; psychological stressor; recruit; response; skills; social; socioeconomics; stressor

An estimated 1 in 5 children are diagnosed with a neurodevelopmental disorder. Neurodevelopmental disorders increase the likelihood of poor academic performance and social challenges. Although there has been some research on early risk for later neurodevelopmental disorders, there are few studies in the first years of life. Maternal immune activation (MIA) to infectious and inflammatory agents raises the risk of neurodevelopmental disorders, such as intellectual disabilities and autism. The overarching purpose of the Career Development Award (K23) is for the candidate, Marisa Spann, a clinical child neuropsychologist, to gain training and mentored research experience on prenatal immunological antecedents of infant brain and behavioral development. With mentorship from Drs. Catherine Monk, Alan Brown, and R. Todd Constable, the application includes training activities for the candidate to achieve the following career goals: 1) develop knowledge of developmental and maternal-fetal immunology; (2) develop skills in perinatal biobehavioral study design and methods; and (3) develop skills in functional neuroimaging and longitudinal statistical modeling. The training and mentored research will occur at Columbia University Medical Center (CUMC)—a top research institution with multi-disciplinary research programs. The research plan will capitalize on a cross-disciplinary model that combines the strengths of a population-based Finnish birth cohort from an extant dataset, and new data collection with a clinical sample of pregnant women recruited from CUMC. The primary goal of the study is to detect associations between prenatal MIA and early brain (head circumference, brain morphometry and connectivity) and behavioral development. In the population-based birth cohort, the candidate will investigate the associations between prenatal maternal influenza infection (influenza immunoglobulin G) and an inflammatory (C-reactive protein) marker, and growth velocity of head circumference from birth to one year. The new data collection will include the recruitment of a new hospital-based sample of pregnant women. In the newly established clinical cohort from CUMC, the candidate will detect associations of maternal influenza and inflammatory markers with neonatal brain morphometry and functional connectivity indices and behavioral reactivity in 3rd trimester fetuses and 4 month old infants. With the well-integrated training and research plans, the K23 award will ensure that the candidate develops the skills necessary to achieve independence in a novel interdisciplinary career area as a perinatal–developmental neuroscience researcher. The candidate will be uniquely positioned to discover distinct and common neurobiological and behavioral trajectories of neurobehavioral health prior to age one, in the service of determining risks for neurodevelopmental disorders, and its early identification.

据估计，五分之一的儿童被诊断患有神经发育障碍。神经发育 失调增加了学习成绩差和社会挑战的可能性。虽 虽然已经有一些关于后期神经发育障碍的早期风险的研究，但在第一阶段的研究很少。 多年的生活。母体对感染性和炎性因子的免疫激活（MIA）增加了以下风险： 神经发育障碍，如智力残疾和自闭症。的总目标 职业发展奖（K23）是为候选人，玛丽莎斯潘，临床儿童神经心理学家， 获得关于婴儿大脑的产前免疫学前因的培训和指导研究经验， 行为发展在凯瑟琳·蒙克、艾伦·布朗和R.托德康斯特布尔， 申请包括为候选人提供培训活动，以实现以下职业目标：1）发展 发育和母胎免疫学知识;（2）发展围产期生物行为研究技能 设计和方法;（3）发展功能神经成像和纵向统计建模的技能。 培训和指导研究将在哥伦比亚大学医学中心（CMEC）进行，该中心是一家顶级研究机构， 拥有多学科研究项目的机构。该研究计划将利用跨学科 该模型结合了现有数据集中基于人口的芬兰出生队列的优势， 数据收集与临床样本的孕妇招募从CNOC。本研究的主要目标 是检测产前MIA和早期脑（头围，脑形态测量和 连接）和行为发展。在基于人口的出生队列中，候选人将调查 产前母亲流感感染（流感免疫球蛋白G）和 炎症（C反应蛋白）标志物以及出生至一岁期间头围的生长速度。 新的数据收集将包括招募新的基于医院的孕妇样本。在 新建立的临床队列，候选人将检测母亲流感和 炎症标志物与新生儿脑形态测量和功能连接指数和行为 妊娠晚期胎儿和4个月大婴儿的反应性。有了完善的培训和研究计划， K23奖将确保候选人发展在小说中实现独立所需的技能 跨学科的职业领域作为围产期发育神经科学研究员。候选人将是 独特的定位，以发现不同的和共同的神经生物学和行为轨迹， 1岁之前的神经行为健康，以确定神经发育障碍的风险， 和早期的鉴定。