Maternal Immune Activation and Fetal-Infant Neurobehavioral Development

据估计，每5名儿童中就有1人被诊断出患有神经发育障碍。神经发育 障碍增加了学习成绩不佳和社会挑战的可能性。尽管有 已经有一些关于晚期神经发育障碍早期风险的研究，但在第一方面的研究很少 生命中的岁月。母体对感染性和炎症性物质的免疫激活(MIA)增加了患 神经发育障碍，如智力残疾和自闭症。最重要的目的是 职业发展奖(K23)是给候选人，临床儿童神经心理学家玛丽莎·斯潘，以 获得有关婴幼儿大脑和脑组织产前免疫因素的培训和辅导研究经验 行为发育。在凯瑟琳·蒙克、艾伦·布朗和R·托德·康斯特布尔博士的指导下， 应聘包括为应聘者提供的培训活动，以实现以下职业目标：1)发展 了解发育和母胎免疫学；(2)掌握围产期生物行为研究技能 设计和方法；以及(3)发展功能神经成像和纵向统计建模的技能。 培训和指导性研究将在哥伦比亚大学医学中心(CUMC)进行，这是一项顶级研究 拥有多学科研究项目的机构。这项研究计划将利用一种跨学科的 该模型结合了现有数据集基于人口的芬兰出生队列的优点，以及新的 数据收集与从中华医学会招募的孕妇的临床样本。这项研究的主要目的 是为了检测产前MIA和早期脑(头围、脑形态测量和 连通性)和行为发展。在以人口为基础的出生队列中，候选人将调查 产前母体流感(流感免疫球蛋白G)感染与AN的关系 炎症(C-反应蛋白)标志物，头围从出生到一岁的生长速度。 新的数据收集将包括招募新的以医院为基础的孕妇样本。在 来自CUMC的新建立的临床队列，候选人将检测母亲流感和 炎性标志物与新生儿脑形态计量学、功能连接指数和行为学的关系 妊娠晚期胎儿和4月龄婴儿的反应性。有了完善的培训和研究计划， K23奖将确保候选人发展在小说中获得独立所需的技能 作为围产期发育神经科学研究人员的跨学科职业领域。候选人将是 独特的定位，可以发现不同的和共同的神经生物学和行为轨迹 一岁之前的神经行为健康，以确定神经发育障碍的风险， 以及它的早期识别。

An estimated 1 in 5 children are diagnosed with a neurodevelopmental disorder. Neurodevelopmental disorders increase the likelihood of poor academic performance and social challenges. Although there has been some research on early risk for later neurodevelopmental disorders, there are few studies in the first years of life. Maternal immune activation (MIA) to infectious and inflammatory agents raises the risk of neurodevelopmental disorders, such as intellectual disabilities and autism. The overarching purpose of the Career Development Award (K23) is for the candidate, Marisa Spann, a clinical child neuropsychologist, to gain training and mentored research experience on prenatal immunological antecedents of infant brain and behavioral development. With mentorship from Drs. Catherine Monk, Alan Brown, and R. Todd Constable, the application includes training activities for the candidate to achieve the following career goals: 1) develop knowledge of developmental and maternal-fetal immunology; (2) develop skills in perinatal biobehavioral study design and methods; and (3) develop skills in functional neuroimaging and longitudinal statistical modeling. The training and mentored research will occur at Columbia University Medical Center (CUMC)—a top research institution with multi-disciplinary research programs. The research plan will capitalize on a cross-disciplinary model that combines the strengths of a population-based Finnish birth cohort from an extant dataset, and new data collection with a clinical sample of pregnant women recruited from CUMC. The primary goal of the study is to detect associations between prenatal MIA and early brain (head circumference, brain morphometry and connectivity) and behavioral development. In the population-based birth cohort, the candidate will investigate the associations between prenatal maternal influenza infection (influenza immunoglobulin G) and an inflammatory (C-reactive protein) marker, and growth velocity of head circumference from birth to one year. The new data collection will include the recruitment of a new hospital-based sample of pregnant women. In the newly established clinical cohort from CUMC, the candidate will detect associations of maternal influenza and inflammatory markers with neonatal brain morphometry and functional connectivity indices and behavioral reactivity in 3rd trimester fetuses and 4 month old infants. With the well-integrated training and research plans, the K23 award will ensure that the candidate develops the skills necessary to achieve independence in a novel interdisciplinary career area as a perinatal–developmental neuroscience researcher. The candidate will be uniquely positioned to discover distinct and common neurobiological and behavioral trajectories of neurobehavioral health prior to age one, in the service of determining risks for neurodevelopmental disorders, and its early identification.