Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience

尽管有证据表明，五分之一的儿童有精神障碍的风险，但只有20%的幼儿接受了 心理健康护理。因此，大量将从精神卫生保健中受益的儿童仍未得到治疗。 我的长期目标是改善儿童早期发现和行为干预的基于大脑的目标 精神障碍。围产期发育神经科学(PDN)领域具有很高的公共卫生水平 重大意义，因为相当大比例的孕妇将经历健康、环境或 心理压力源，对后代有早期和长期的影响。增加的数量 能够支持PDN培训的研究计划至关重要。K24将使我能够：1)扩展我的 在高级分析方法方面的专业知识，以支持学员研究，以及2)建立国际 公认的研究和培训计划侧重于胎儿-婴儿大脑和心理健康的行为起源。 我的K24培训计划，哥伦比亚接触，稳定和在PDN的成功将提供个性化的 研究培训方法：在早期和发展阶段评估被辅导者的研究技能和职业目标 个性化培训模块；教学方法；体验式动手培训；以及随后的研究效率 他们的个性化计划。该计划还包括每月一系列的研讨会，在科学和技术之间交替进行 职业关系网话题。我们之前的研究表明，早期可能存在共同的生物学途径 暴露对后代产生精神风险的影响--最近对免疫系统的关注 系统和/或下丘脑-垂体-肾上腺轴，以及参与行为调节的大脑区域。使用 通过K24获得的扩展分析技能，我和我的学员将进行研究，以检查 四个关键的产前暴露：母体抑郁、体重指数、感染和血糖相关 与行为有关的大脑区域(如背侧前扣带回)的连通性和形态 监管。在队列的一个子集中，我们还将考虑炎症和 糖皮质激素。我有一个独一无二的机会来收集孕妇队列中的数据--胎儿双胞胎 参与哥伦比亚大学欧文医学中心的研究(2004年至今；N~500)-大型 具有多样化患者群体的中心-并执行利用健康信息的新数据收集 技术(例如，电子病历)。该数据集将作为我的学员生成 试点项目和手稿，以及在PDN领域开展项目的实际经验 他/她的职业目标在这个资助机制的范围内。我对和正在进行的研究的坚定承诺 在以患者为中心的研究中，侧重于确定精神疾病风险的早期先兆，个体化 指导计划，指导对象直接参与研究，以及量身定做的职业发展 哥伦比亚大学欧文医学中心的项目是这一应用程序的优势。K24的学员将是 在发现与风险相关的神经生物学和行为途径方面具有独特的地位。

Despite evidence that 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive mental health care. Thus, a high number of children who would benefit from mental health care remain untreated. My long-term goal is to improve brain-based targets for early detection and behavioral interventions of childhood psychiatric disorders. The area of perinatal-developmental neuroscience (PDN) is of high public health significance as a substantial proportion of pregnant women will experience health, environmental, or psychological stressors, which have early and long-lasting effects on offspring. Increasing the number of research programs that can support training in PDN is paramount. The K24 will allow me to: 1) expand my expertise in advanced analytic methods to support trainee research, and 2) establish an internationally recognized research and training program focused on fetal-infant brain and behavioral origins of mental health. My K24 training program, the Columbia Engagement, Stability, and Success in PDN will provide an individualized approach to research training: assessing the research skills and career goals of mentees early on and developing personalized training modules; didactics; experiential, hands-on training; and research productivity that follow their individualized plan. The program also includes a monthly seminar series alternating between science and career-networking topics. Our prior studies suggest there may be common biological pathways by which early exposures exert their influence on offspring conferring psychiatric risk – with recent attention to the immune system and/or hypothalamic-pituitary-adrenal axis, and brain regions involved in behavioral regulation. Using the expanded analytic skills obtained through this K24, my mentees and I will conduct studies to examine whether four key prenatal exposures: maternal depression, body mass index, infection, and blood glucose are associated with connectivity and morphology of brain regions (e.g., dorsal anterior cingulate) involved in behavioral regulation. In a subset of the cohort, we will also consider the potential mediating effects of inflammation and glucocorticosteriods. I have a unique opportunity to pool data from cohorts of pregnant women-fetal dyads involved in research studies (2004 to present; n~500) at Columbia University Irving Medical Center – a large center with a diverse patient population – and perform new data collection harnessing health information technology (e.g., electronic medical records). The data set will serve as a platform for my mentees to produce pilot projects and manuscripts, and practical experience conducting a project in an area of PDN that matches his/her career goals within the scope of this funding mechanism. My strong commitment to and ongoing research in patient-oriented research focused on identifying early antecedents of psychiatric risk, individualized mentorship plans, direct involvement of mentees in the conduct of research, and tailored career development program at Columbia University Irving Medical Center are strengths of this application. The K24 mentees will be uniquely positioned to discover neurobiological and behavioral pathways associated with risk.